Effects of pre-treatment with aflatoxin on a second aflatoxin treatment in guinea pigs

• Published in: Mycopathologia (1975) Vol. 99; no. 2; p. 107
• Main Authors: Peden, W M, Richard, J L, Thurston, J R, Sacks, J L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.08.1987
• Subjects: Aflatoxins - administration & dosage; Animals; Aspergillus flavus; Body Weight; Complement System Proteins - analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Glycocholic Acid - blood; Growth - drug effects; Guinea Pigs; Immunity, Cellular; Lymphocyte Activation; Mushroom Poisoning - blood; Mushroom Poisoning - etiology; Mushroom Poisoning - pathology

Two-hundred guinea pigs, weighing approximately 500 grams each, were placed in 8 groups, 4 of which received 20 micrograms/kg/day of partially purified aflatoxin for 7 days, followed by a 7 day recovery period. Paired groups then received 0, 20, 35 or 50 micrograms/kg/day of partially purified aflat...