Vision-threatening reactions of hyaluronidase after local anesthesia: A case series and review of literature

Hyaluronidase is an often used drug in ophthalmology to enhance the effect of local anesthesia. Hypersensitivity reaction to hyaluronidase is a rare complication. Various cases showing varied presentations have been reported in the literature. Here, we report three cases presented with hypersensitiv...

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Published inIndian Journal of Ophthalmology Case Reports Vol. 3; no. 3; pp. 888 - 891
Main Authors Singh, Arti, Singh, Kamaljeet, Rana, Jagriti, Singh, Upasna, Sharma, Anirrud, Kumar, Vineet
Format Journal Article
LanguageEnglish
Published Wolters Kluwer India Pvt. Ltd 01.07.2023
Medknow Publications and Media Pvt. Ltd
Subjects
Adverse and side effects
Case studies
Complications and side effects
Drugs
Eye diseases
Local anesthesia
Risk factors
Vision disorders
India
proptosis
hyaluronidase
Aseptic orbital cellulitis
hypersensitivity reaction
blisters
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Abstract Hyaluronidase is an often used drug in ophthalmology to enhance the effect of local anesthesia. Hypersensitivity reaction to hyaluronidase is a rare complication. Various cases showing varied presentations have been reported in the literature. Here, we report three cases presented with hypersensitivity reaction to hyaluronidase, which were more fulminant, presented with proptosis, blisters, necrosis, and loss of corneal sensation. When such a situation arises, early diagnosis, differentiation from infectious etiology, and timely management with immunosuppressive therapy are crucial for these vision-threatening complications.
AbstractList Hyaluronidase is an often used drug in ophthalmology to enhance the effect of local anesthesia. Hypersensitivity reaction to hyaluronidase is a rare complication. Various cases showing varied presentations have been reported in the literature. Here, we report three cases presented with hypersensitivity reaction to hyaluronidase, which were more fulminant, presented with proptosis, blisters, necrosis, and loss of corneal sensation. When such a situation arises, early diagnosis, differentiation from infectious etiology, and timely management with immunosuppressive therapy are crucial for these vision-threatening complications.
Audience Academic
Author Singh, Upasna
Singh, Kamaljeet
Rana, Jagriti
Singh, Arti
Kumar, Vineet
Sharma, Anirrud
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Issue 3
Keywords proptosis
hyaluronidase
Aseptic orbital cellulitis
hypersensitivity reaction
blisters
Language English
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Snippet Hyaluronidase is an often used drug in ophthalmology to enhance the effect of local anesthesia. Hypersensitivity reaction to hyaluronidase is a rare...
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SubjectTerms Adverse and side effects
Case studies
Complications and side effects
Drugs
Eye diseases
Local anesthesia
Risk factors
Vision disorders
Title Vision-threatening reactions of hyaluronidase after local anesthesia: A case series and review of literature
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