Hypergeometric Model of Evolution of Conserved Protein Coding Sequences in the Proteomes

• Published in: Fluctuation and noise letters Vol. 3; no. 3; pp. L295 - L324
• Main Author: Kuznetsov, Vladimir A.
• Format: Journal Article
• Language: English
• Published: World Scientific Publishing Company 01.09.2003
• Subjects: conserved sequences; Protein domains; Kolmogorov–Waring distribution; motifs; birth-death stochastic processes; generalized hypergeometric series; evolution dynamics; Yule distribution

The diversity of protein sequences that exists today has probably evolved from antecedent evolutionarily- conserved domain-like sequences (i.e. motifs, repeats, structural domains) encoded by short ancient genes. We have studied the statistical distributions of the occurrences of the domain-like fam...