Modulation of the intrinsic viscosity of hyaluronic acid formed by human “fibroblasts” in vitro: The effects of hydrocortisone and colchicine

Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells in vitro is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment....

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Published inBiochimica et biophysica acta. Specialized section on mucoproteins and mucopolysaccharides Vol. 83; no. 2; pp. 165 - 177
Main Authors William Castor, C., Prince, Robert K.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 07.07.1964
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Abstract Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells in vitro is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment. Conversely, the initial lag phase of culture growth and colchicine treatment are attended by formation of hyaluronic acid with a high intrinsic viscosity.
AbstractList Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells in vitro is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment. Conversely, the initial lag phase of culture growth and colchicine treatment are attended by formation of hyaluronic acid with a high intrinsic viscosity.
Author William Castor, C.
Prince, Robert K.
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Cites_doi 10.1002/9780470110171.ch11
10.1016/0006-3002(56)90188-3
10.3109/03009745909165002
10.1016/0014-4827(61)90023-4
10.1042/bj0760124
10.1016/S0021-9258(17)35155-4
10.1016/0006-3002(60)90826-X
10.3181/00379727-89-21777
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Castor, Fries (BIB4) 1961; 57
Oyama, Eagle (BIB6) 1956; 91
Hedberg, Moritz (BIB14) 1959; 5
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Volkin, Cohn (BIB7) 1954; 1
Castor, Prince, Dorstewitz (BIB5) 1962; 11
Meyer, Davidson, Linker, Hoffman (BIB1) 1956; 21
Sundblad (BIB8) 1953; 58
Dische (BIB11) 1947; 167
Prince, Castor (BIB9) 1961; 23
Castor (BIB10) 1962; 60
Fessler (BIB3) 1960; 76
Laurent, Ryan, Pietruszkiewicz (BIB2) 1960; 42
Fessler (10.1016/0926-6526(64)90032-1_BIB3) 1960; 76
Laurent (10.1016/0926-6526(64)90032-1_BIB2) 1960; 42
Castor (10.1016/0926-6526(64)90032-1_BIB5) 1962; 11
Kling (10.1016/0926-6526(64)90032-1_BIB12) 1955; 89
Hedberg (10.1016/0926-6526(64)90032-1_BIB13) 1958; 98
Dische (10.1016/0926-6526(64)90032-1_BIB11) 1947; 167
Castor (10.1016/0926-6526(64)90032-1_BIB10) 1962; 60
Oyama (10.1016/0926-6526(64)90032-1_BIB6) 1956; 91
Castor (10.1016/0926-6526(64)90032-1_BIB4) 1961; 57
Volkin (10.1016/0926-6526(64)90032-1_BIB7) 1954; 1
Sundblad (10.1016/0926-6526(64)90032-1_BIB8) 1953; 58
Prince (10.1016/0926-6526(64)90032-1_BIB9) 1961; 23
Hedberg (10.1016/0926-6526(64)90032-1_BIB14) 1959; 5
Meyer (10.1016/0926-6526(64)90032-1_BIB1) 1956; 21
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Title Modulation of the intrinsic viscosity of hyaluronic acid formed by human “fibroblasts” in vitro: The effects of hydrocortisone and colchicine
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