NOX4-Derived ROS Mediates TGF- β 1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1 α Pathway in Glioblastoma

• Published in: Oxidative medicine and cellular longevity Vol. 2021; no. 1; p. 5549047
• Main Authors: Su, Xiangsheng, Yang, Yihang, Guo, Changfa, Zhang, Rui, Sun, Shicheng, Wang, Yanjun, Qiao, Qiujiang, Fu, Yibing, Pang, Qi
• Format: Journal Article
• Language: English
• Published: United States 2021
• Subjects: Animals; Epithelial-Mesenchymal Transition; Glioblastoma - genetics; Glioblastoma - pathology; Humans; Male; Mice; Mice, Nude; NADPH Oxidase 4 - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Reactive Oxygen Species - metabolism; Signal Transduction; Transfection; Transforming Growth Factor beta1 - metabolism

Current studies on tumor progression focus on the roles of cytokines in the tumor microenvironment (TME), and recent research shows that transforming growth factor- 1 (TGF- 1) released from TME plays a pivotal role in tumor development and malignant transformation. The alteration in cellular metabol...