Impact of age on PUAL as an indicator of opioid effect in adult subjects

• Published in: Journal of clinical monitoring and computing
• Main Authors: McKay, Rachel Eshima, Kohn, Michael A., Larson, Merlín D.
• Format: Journal Article
• Language: English
• Published: Netherlands 18.08.2025
• Subjects: Opioid induced respiratory depression; Opioid pharmacodynamics; Age-related modulation; Quantitative pupil analysis

Opioid-induced respiratory depression (OIRD) remains a critical safety concern, particularly in older adults, yet timely, reliable detection methods are limited. Decline of pupillary unrest in ambient light (PUAL) has demonstrated potential as a marker of opioid effect in young adult subjects. We ev...