Insulin-like growth factor binding proteins-2 and -3 stimulate growth hormone receptor binding and mitogenesis in rat osteosarcoma cells

• Published in: Endocrinology (Philadelphia) Vol. 136; no. 10; p. 4210
• Main Authors: Slootweg, M C, Ohlsson, C, Salles, J P, de Vries, C P, Netelenbos, J C
• Format: Journal Article
• Language: English
• Published: United States 01.10.1995
• Subjects: Animals; Carrier Proteins - pharmacology; Cell Division - drug effects; Dose-Response Relationship, Drug; Growth Hormone - metabolism; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor II - pharmacology; Osteosarcoma - metabolism; Rats; Receptors, Somatotropin - genetics; Receptors, Somatotropin - metabolism; RNA, Messenger - analysis; Time Factors; Tumor Cells, Cultured

GH exerts its biological actions on osteoblasts through a specific high affinity receptor expressed on these cells. GH receptor binding is positively modulated by a number of factors, including retinoic acid and dexamethasone, whereas fetal calf serum strongly decreases the binding. To identify resp...