Effectiveness and Safety of STYLAGE® L Lidocaine in the Treatment of Nasolabial Folds (NICE Study): A Randomized, Double-Blind, Split-Face Controlled Study

• Published in: Aesthetic plastic surgery
• Main Authors: Converset-Viethel, Sophie, Dobosz, Magdalena, Baspeyras, Martine, Skretkowicz-Szarmach, Kamila, Schlaudraff, Kai-Uwe
• Format: Journal Article
• Language: English
• Published: United States 19.08.2025
• Subjects: Stylage; Dermal filler; Lidocaine; Randomized controlled trial (RCT); Crossed-linked hyaluronic acid; Nasolabial fold treatment

Prominent nasolabial folds (NLFs) are a typical manifestation of aging. Hyaluronic acid (HA)-based injectable fillers are commonly used for correction. The NICE Study primarily evaluated non-inferiority of STYLAGE L Lidocaine (STYL-L), a cross-linked HA filler with lidocaine, versus the similar prod...