METTL3/16-mediated m6A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells

Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N6-methyladenosine (m6A) also contributes to tumour progression. However, the potential roles of m6A in modulating macrophages in hepatocellular carcinoma (HCC) are poorly understood. He...

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Published inClinical immunology (Orlando, Fla.) Vol. 261; p. 109924
Main Authors Wei, Huamei, Li, Wenchuan, Yang, Meng, Fang, Quan, Nian, Jiahui, Huang, Youguan, Wei, Qing, Huang, Zihua, Liu, Guoman, Xu, Zuoming, Hu, Anbin, Pu, Jian
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.04.2024
Subjects
Crosstalk
Hepatocellular carcinoma
N6-methyladenosine
Positive feedback loop
Tumour-associated macrophage
TAM
lncRNA
IHC
Crosstalk
Hepatocellular carcinoma
OPN
ChIP
ATCC
TUNEL
Positive feedback loop
FBS
CCK-8
cDNA
LIHC
IF
PMA
qRT-PCR
BCLC
HCC
CM
Tumour-associated macrophage
TME
MeRIP
TCGA
NC
EdU
FISH
RIP
N6-methyladenosine
S100A9
ELISA
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Abstract Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N6-methyladenosine (m6A) also contributes to tumour progression. However, the potential roles of m6A in modulating macrophages in hepatocellular carcinoma (HCC) are poorly understood. Here, we identified ZNNT1 as an HCC-related m6A modification target, which was upregulated and associated with poor prognosis of HCC. METTL3 and METTL16-mediated m6A modification contributed to ZNNT1 upregulation through stabilizing ZNNT1 transcript. ZNNT1 exerted oncogenic roles in HCC. Furthermore, ZNNT1 recruited and induced M2 polarization of macrophages via up-regulating osteopontin (OPN) expression and secretion. M2 Macrophages-recruited by ZNNT1-overexpressed HCC cells secreted S100A9, which further upregulated ZNNT1 expression in HCC cells via AGER/NF-κB signaling. Thus, this study demonstrates that m6A modification activated the ZNNT1/OPN/S100A9 positive feedback loop, which promoted macrophages recruitment and M2 polarization, and enhanced malignant features of HCC cells. m6A modification-triggered ZNNT1/OPN/S100A9 feedback loop represents potential therapeutic target for HCC. [Display omitted] •ZNNT1 was an m6A modification target, whose expression level and m6A modification level were both increased in HCC.•METTL3 and METTL16-mediated m6A modification contributed to ZNNT1 upregulation through increasing ZNNT1 transcript stability.•ZNNT1 recruited and induced M2 polarization of macrophages via up-regulating OPN expression and secretion.•M2 Macrophages secreted S100A9, which further upregulated ZNNT1 expression in HCC cells via AGER/NF-κB signaling.
AbstractList Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N6-methyladenosine (m6A) also contributes to tumour progression. However, the potential roles of m6A in modulating macrophages in hepatocellular carcinoma (HCC) are poorly understood. Here, we identified ZNNT1 as an HCC-related m6A modification target, which was upregulated and associated with poor prognosis of HCC. METTL3 and METTL16-mediated m6A modification contributed to ZNNT1 upregulation through stabilizing ZNNT1 transcript. ZNNT1 exerted oncogenic roles in HCC. Furthermore, ZNNT1 recruited and induced M2 polarization of macrophages via up-regulating osteopontin (OPN) expression and secretion. M2 Macrophages-recruited by ZNNT1-overexpressed HCC cells secreted S100A9, which further upregulated ZNNT1 expression in HCC cells via AGER/NF-κB signaling. Thus, this study demonstrates that m6A modification activated the ZNNT1/OPN/S100A9 positive feedback loop, which promoted macrophages recruitment and M2 polarization, and enhanced malignant features of HCC cells. m6A modification-triggered ZNNT1/OPN/S100A9 feedback loop represents potential therapeutic target for HCC. [Display omitted] •ZNNT1 was an m6A modification target, whose expression level and m6A modification level were both increased in HCC.•METTL3 and METTL16-mediated m6A modification contributed to ZNNT1 upregulation through increasing ZNNT1 transcript stability.•ZNNT1 recruited and induced M2 polarization of macrophages via up-regulating OPN expression and secretion.•M2 Macrophages secreted S100A9, which further upregulated ZNNT1 expression in HCC cells via AGER/NF-κB signaling.
Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N6-methyladenosine (m6A) also contributes to tumour progression. However, the potential roles of m6A in modulating macrophages in hepatocellular carcinoma (HCC) are poorly understood. Here, we identified ZNNT1 as an HCC-related m6A modification target, which was upregulated and associated with poor prognosis of HCC. METTL3 and METTL16-mediated m6A modification contributed to ZNNT1 upregulation through stabilizing ZNNT1 transcript. ZNNT1 exerted oncogenic roles in HCC. Furthermore, ZNNT1 recruited and induced M2 polarization of macrophages via up-regulating osteopontin (OPN) expression and secretion. M2 Macrophages-recruited by ZNNT1-overexpressed HCC cells secreted S100A9, which further upregulated ZNNT1 expression in HCC cells via AGER/NF-κB signaling. Thus, this study demonstrates that m6A modification activated the ZNNT1/OPN/S100A9 positive feedback loop, which promoted macrophages recruitment and M2 polarization, and enhanced malignant features of HCC cells. m6A modification-triggered ZNNT1/OPN/S100A9 feedback loop represents potential therapeutic target for HCC.
ArticleNumber 109924
Author Yang, Meng
Li, Wenchuan
Hu, Anbin
Wei, Qing
Wei, Huamei
Nian, Jiahui
Liu, Guoman
Xu, Zuoming
Huang, Zihua
Pu, Jian
Huang, Youguan
Fang, Quan
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  organization: Department of Pathology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
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  surname: Li
  fullname: Li, Wenchuan
  organization: Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
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  givenname: Meng
  surname: Yang
  fullname: Yang, Meng
  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  organization: Graduate College of Youjiang Medical University for Nationalities, Baise, China
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  surname: Pu
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  email: jian_pu@126.com
  organization: Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
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Cites_doi 10.1016/j.ccell.2021.05.016
10.1186/s11658-022-00349-1
10.1038/s41590-022-01268-1
10.1093/nar/gkab1113
10.1111/febs.15726
10.1038/s41576-022-00534-0
10.1038/s41416-022-01799-2
10.1038/s41416-021-01600-w
10.1038/ncb3538
10.1186/s10020-022-00452-1
10.1093/nar/gkw104
10.1002/hep.24606
10.1038/s41590-022-01398-6
10.1111/febs.13839
10.3322/caac.21660
10.1136/gutjnl-2019-318419
10.1186/s11658-021-00264-x
10.1038/s41590-022-01267-2
10.1056/NEJMra1713263
10.1186/s11658-021-00282-9
10.1186/s11658-023-00445-w
10.1038/s41590-021-00921-5
10.1038/s41416-023-02246-6
10.1186/s11658-022-00310-2
10.1186/s11658-021-00247-y
10.1186/s11658-021-00269-6
10.1111/febs.15333
10.1002/hep4.1845
10.1038/s41590-023-01548-4
10.3390/cancers12113379
10.1038/s41575-019-0186-y
10.1038/s41416-023-02275-1
10.1186/s10020-021-00403-2
10.1038/s41416-021-01581-w
10.1186/s11658-021-00295-4
10.1038/s41590-022-01385-x
10.3390/ani12202823
10.1038/s41556-021-00820-9
10.1016/j.canlet.2021.10.033
10.1186/s11658-022-00309-9
10.1186/s11658-022-00325-9
10.1038/s41419-022-04505-5
10.1186/s11658-022-00313-z
10.1038/s41556-021-00672-3
10.1016/j.ccr.2014.03.010
10.1186/s11658-021-00304-6
10.1186/s11658-022-00322-y
10.1002/ijc.24556
10.1016/j.celrep.2021.108724
10.1016/j.omtn.2019.08.020
10.1111/jcmm.14706
10.1038/s41416-021-01490-y
10.1016/j.ccell.2021.02.013
10.1002/ijc.33371
10.1038/s41590-022-01145-x
10.1038/s41416-021-01314-z
10.1186/s12943-021-01343-5
10.1038/ng.3192
10.1186/s12943-017-0681-0
10.1093/nar/gkx247
10.1093/bioinformatics/bts344
10.1080/15548627.2019.1659614
10.1186/s11658-022-00350-8
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Keywords TAM
lncRNA
IHC
Crosstalk
Hepatocellular carcinoma
OPN
ChIP
ATCC
TUNEL
Positive feedback loop
FBS
CCK-8
cDNA
LIHC
IF
PMA
qRT-PCR
BCLC
HCC
CM
Tumour-associated macrophage
TME
MeRIP
TCGA
NC
EdU
FISH
RIP
N6-methyladenosine
S100A9
ELISA
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References Shimura, Kandimalla, Okugawa, Ohi, Toiyama, He, Goel (bb0220) 2022; 126
Lu, Huang, Mo, Da, Li, Fan, Lu (bb0040) 2022; 27
Pu, Wang, Wei, Lu, Wu, Wu, Shao, Luo, Lu (bb0240) 2019; 18
Castro-Mondragon, Riudavets-Puig, Rauluseviciute, Lemma, Turchi, Blanc-Mathieu, Lucas, Boddie, Khan, Manosalva Perez, Fornes, Leung, Aguirre, Hammal, Schmelter, Baranasic, Ballester, Sandelin, Lenhard, Vandepoele, Wasserman, Parcy, Mathelier (bb0260) 2022; 50
Li, Ding, Hu, Zhao, Zhu, Ding, Yuan, Guo (bb0135) 2021; 27
Yin, Zhao (bb0310) 2022; 27
Li, He, Yang, Ge, Zhang, Zhong, Fan (bb0300) 2020; 16
Xing, Liu, Qi, Liu, Wang, Zhang (bb0020) 2021; 26
Gao, Wang, Fan, Luo, Ma, Hu, Li, Liang, Lin, Xu (bb0180) 2022; 28
Chen, Lu, Cai, Han, Ding, Chu, Zhou, Wang (bb0275) 2023; 28
Yuan, Liu, Wang, Pan, Tao, Zhou, Wang, Sun (bb0170) 2017; 19
Gao, Huang, Wang, Xie, Wang (bb0065) 2022; 27
Ouyang, Zhong, Zhang, Yang, Wu, Hou, Xiong, Li, Zhang, Gong, He, Tang, Zhang, Xiang, Zhou, Ma, Li, Li, Zeng, Guo, Xiong (bb0150) 2022; 126
Zhou, Zeng, Li, Zhang, Cui (bb0250) 2016; 44
Zhu, Yuan, Zhu, Li, Cheng (bb0190) 2016; 283
Ito-Kureha, Leoni, Borland, Cantini, Bataclan, Metzger, Ammann, Krug, Marsico, Kaiser, Canzar, Feske, Monticelli, Konig, Heissmeyer (bb0270) 2022; 23
Lan, Xu, Shi, Pan, Tao (bb0210) 2022; 27
Chakraborty, Dash, Dalpati, Kumar, Jain, Sarangi (bb0080) 2021; 288
Ma, Sun, Duan, Han, Barr, Zhang, Bissonnette, Kortylewski, He, Chen, Caligiuri, Yu (bb0230) 2023; 24
Li, Li, Wang, Liu, Zhu, Dai, Zhai, Liu, Lin, Ge, Sun, Wang, Yuan (bb0025) 2021; 125
Khalili-Tanha, Moghbeli (bb0165) 2021; 26
Paramasivam, Priyadharsini (bb0225) 2021; 124
Tang, Li, Kang, Gao, Li, Zhang (bb0245) 2017; 45
de Jong, Valderrama, Perera, Juanpere, Cejas, Long, Alba, Gibb, Bellmunt (bb0185) 2022; 127
Zhang, Hao, Zhang (bb0120) 2022; 27
Sun, Hong, Liu, Ren, He, Jiang, Ouyang, Chu, Zhang (bb0280) 2022; 12
Pan, Guo, Liu, Pan, Yang, Yao, Yuan (bb0160) 2022; 27
Zhang, Zhang, Zhao, Ito, Jin, Aparicio, Zhou, Guichard, Fang, Que, Urban, Hanna, Ghosh, Wu, Ding, Basu, Huang (bb0265) 2023; 24
Liu, Huang, Xie, Lin, Zheng (bb0155) 2021; 26
Yuan, Yang, Chen, Lu, Huo, Zhou, Wang, Sun (bb0315) 2011; 54
Ni, Huang, Wang (bb0130) 2021; 26
Yuan, Yang, Wang, Ma, Guo, Tao, Liu, Pan, Wang, Zhou, Wang, Wang, Yang, Yang, Zhou, Yang, Sun (bb0285) 2014; 25
Xu, Wu, Yan, Shu, Fan, Tong, Li (bb0305) 2022; 525
Christofides, Katopodi, Cao, Karagkouni, Aliazis, Yenyuwadee, Aksoylar, Pal, Mahmoud, Strauss, Tijaro-Ovalle, Boon, Asara, Vlachos, Patsoukis, Boussiotis (bb0055) 2023; 24
Raines, Zhao, Wang, Chen, Gallart-Ayala, Hsueh, Cao, Koh, Alamonte-Loya, Liu, Ivanisevic, Lio, Ho, Huang (bb0070) 2022; 23
Christofides, Strauss, Yeo, Cao, Charest, Boussiotis (bb0045) 2022; 23
Consonni, Bleve, Totaro, Storto, Kunderfranco, Termanini, Pasqualini, Ali, Pandolfo, Sgambelluri, Grazia, Santinami, Maurichi, Milione, Erreni, Doni, Fabbri, Gribaldo, Rulli, Soares, Torri, Mortarini, Anichini, Sica (bb0050) 2021; 22
Iyer, Niknafs, Malik, Singhal, Sahu, Hosono, Barrette, Prensner, Evans, Zhao, Poliakov, Cao, Dhanasekaran, Wu, Robinson, Beer, Feng, Iyer, Chinnaiyan (bb0110) 2015; 47
Yuan, Gu, Zhang, Liu, Wang, Tian, Chen, Zhang (bb0100) 2021; 34
Yan, Wan (bb0085) 2021; 288
Zhu, Yang, Xu, Gao, Zhang, Hsu, Li, Lim, Sheng, Zhang, Li, Luo, Zheng, Zhao, Lu, Jia, Hung, Dong, Qin (bb0105) 2019; 68
Zhao, Li, Zhao, Wang, Zhu, Feng, Zhu, Dou, Fan, Hu, Jia, Liu (bb0095) 2021; 20
Zhang, Yuan, Hu, Chen, Liu, Zhang, Sun, Guo (bb0140) 2017; 51
Diao, Zhang, Zhang (bb0205) 2023; 129
Villanueva (bb0015) 2019; 380
Desert, Ge, Song, Han, Lantvit, Chen, Das, Athavale, Abraham-Enachescu, Blajszczak, Chen, Musso, Guzman, Hoshida, Nieto (bb0295) 2022; 6
Wang, Song, Shi, Yang, Li, Yin (bb0145) 2022; 27
Wei, Zhu, Yu, Wang, Gao, Zhou, Lin, Shao, Wang, Lu, Qin (bb0090) 2021; 148
Jeggari, Marks, Larsson (bb0255) 2012; 28
Sung, Ferlay, Siegel, Laversanne, Soerjomataram, Jemal, Bray (bb0005) 2021; 71
Li, Yan, Zhang, Chen, Ding, Yin, Li, Zhu, Sun, Yuan, Guo (bb0320) 2020; 24
Braun, Street, Burke, Cookmeyer, Denize, Pedersen, Gohil, Schindler, Pomerance, Hirsch, Bakouny, Hou, Forman, Huang, Li, Cui, Keskin, Steinharter, Bouchard, Sun, Pimenta, Xu, Mahoney, McGregor, Hirsch, Chang, Livak, McDermott, Shukla, Olsen, Signoretti, Sharpe, Irizarry, Choueiri, Wu (bb0075) 2021; 39
Boulias, Greer (bb0195) 2023; 24
Tang, Li, Wang, Wu, Hou, Ouyang, Fan, Li, Wang, Guo, Zhou, Liao, Wang, Xiang, Jiang, Li, Zeng, Xiong (bb0200) 2023; 129
Zhang, Qu, Ji, Hao, Su, Yao, Zuo, Chen, Yang, Ma (bb0215) 2022; 27
Li, Chen, Liu, Shi, Liu, Liu, Wu, Fang, Bao, Jiang, Yuan, Qu, Wang (bb0175) 2017; 16
Wei, Xu, Chen, Wei, Huang, Liu, Li, Wang, Tang, Pu (bb0235) 2022; 13
Huang, Wang, Thompson, Yin, Alexander, Qin, Mudgal, Wu, Liang, Tan, Pan, Yuan, Wan, Li, Wang (bb0030) 2022; 24
Li, Kryczek, Nam, Li, Li, Li, Wei, Grove, Vatan, Zhou, Du, Lin, Wang, Subramanian, Moon, Cieslik, Cohen, Zou (bb0115) 2021; 23
Moorman, Poschel, Klement, Lu, Redd, Liu (bb0290) 2020; 12
Zhou, Ding, Pan, Zhu, Li, Zheng (bb0060) 2009; 125
Li, Wolf, Raulet, Akkari, Pittet, Rodriguez, Kaplan, Munitz, Zhang, Cheng, Bhardwaj (bb0035) 2021; 39
Zhou, Xu, Wang, Zhang, Zhang, Li, Yao, Huang, Huang, Luo (bb0125) 2021; 26
Yang, Hainaut, Gores, Amadou, Plymoth, Roberts (bb0010) 2019; 16
Li (10.1016/j.clim.2024.109924_bb0135) 2021; 27
Wang (10.1016/j.clim.2024.109924_bb0145) 2022; 27
Zhang (10.1016/j.clim.2024.109924_bb0265) 2023; 24
Christofides (10.1016/j.clim.2024.109924_bb0045) 2022; 23
Yuan (10.1016/j.clim.2024.109924_bb0170) 2017; 19
Yuan (10.1016/j.clim.2024.109924_bb0315) 2011; 54
Zhang (10.1016/j.clim.2024.109924_bb0120) 2022; 27
Xing (10.1016/j.clim.2024.109924_bb0020) 2021; 26
Iyer (10.1016/j.clim.2024.109924_bb0110) 2015; 47
Castro-Mondragon (10.1016/j.clim.2024.109924_bb0260) 2022; 50
Zhang (10.1016/j.clim.2024.109924_bb0140) 2017; 51
de Jong (10.1016/j.clim.2024.109924_bb0185) 2022; 127
Zhou (10.1016/j.clim.2024.109924_bb0060) 2009; 125
Huang (10.1016/j.clim.2024.109924_bb0030) 2022; 24
Ouyang (10.1016/j.clim.2024.109924_bb0150) 2022; 126
Jeggari (10.1016/j.clim.2024.109924_bb0255) 2012; 28
Consonni (10.1016/j.clim.2024.109924_bb0050) 2021; 22
Braun (10.1016/j.clim.2024.109924_bb0075) 2021; 39
Li (10.1016/j.clim.2024.109924_bb0115) 2021; 23
Pu (10.1016/j.clim.2024.109924_bb0240) 2019; 18
Yan (10.1016/j.clim.2024.109924_bb0085) 2021; 288
Pan (10.1016/j.clim.2024.109924_bb0160) 2022; 27
Wei (10.1016/j.clim.2024.109924_bb0235) 2022; 13
Ma (10.1016/j.clim.2024.109924_bb0230) 2023; 24
Chakraborty (10.1016/j.clim.2024.109924_bb0080) 2021; 288
Yin (10.1016/j.clim.2024.109924_bb0310) 2022; 27
Sun (10.1016/j.clim.2024.109924_bb0280) 2022; 12
Boulias (10.1016/j.clim.2024.109924_bb0195) 2023; 24
Lu (10.1016/j.clim.2024.109924_bb0040) 2022; 27
Li (10.1016/j.clim.2024.109924_bb0300) 2020; 16
Lan (10.1016/j.clim.2024.109924_bb0210) 2022; 27
Zhao (10.1016/j.clim.2024.109924_bb0095) 2021; 20
Zhu (10.1016/j.clim.2024.109924_bb0190) 2016; 283
Zhou (10.1016/j.clim.2024.109924_bb0250) 2016; 44
Raines (10.1016/j.clim.2024.109924_bb0070) 2022; 23
Wei (10.1016/j.clim.2024.109924_bb0090) 2021; 148
Shimura (10.1016/j.clim.2024.109924_bb0220) 2022; 126
Moorman (10.1016/j.clim.2024.109924_bb0290) 2020; 12
Ni (10.1016/j.clim.2024.109924_bb0130) 2021; 26
Liu (10.1016/j.clim.2024.109924_bb0155) 2021; 26
Diao (10.1016/j.clim.2024.109924_bb0205) 2023; 129
Tang (10.1016/j.clim.2024.109924_bb0200) 2023; 129
Chen (10.1016/j.clim.2024.109924_bb0275) 2023; 28
Ito-Kureha (10.1016/j.clim.2024.109924_bb0270) 2022; 23
Yang (10.1016/j.clim.2024.109924_bb0010) 2019; 16
Zhang (10.1016/j.clim.2024.109924_bb0215) 2022; 27
Tang (10.1016/j.clim.2024.109924_bb0245) 2017; 45
Sung (10.1016/j.clim.2024.109924_bb0005) 2021; 71
Villanueva (10.1016/j.clim.2024.109924_bb0015) 2019; 380
Khalili-Tanha (10.1016/j.clim.2024.109924_bb0165) 2021; 26
Li (10.1016/j.clim.2024.109924_bb0025) 2021; 125
Zhu (10.1016/j.clim.2024.109924_bb0105) 2019; 68
Li (10.1016/j.clim.2024.109924_bb0175) 2017; 16
Xu (10.1016/j.clim.2024.109924_bb0305) 2022; 525
Li (10.1016/j.clim.2024.109924_bb0035) 2021; 39
Gao (10.1016/j.clim.2024.109924_bb0065) 2022; 27
Christofides (10.1016/j.clim.2024.109924_bb0055) 2023; 24
Desert (10.1016/j.clim.2024.109924_bb0295) 2022; 6
Zhou (10.1016/j.clim.2024.109924_bb0125) 2021; 26
Gao (10.1016/j.clim.2024.109924_bb0180) 2022; 28
Yuan (10.1016/j.clim.2024.109924_bb0285) 2014; 25
Yuan (10.1016/j.clim.2024.109924_bb0100) 2021; 34
Paramasivam (10.1016/j.clim.2024.109924_bb0225) 2021; 124
Li (10.1016/j.clim.2024.109924_bb0320) 2020; 24
References_xml – volume: 380
  start-page: 1450
  year: 2019
  end-page: 1462
  ident: bb0015
  article-title: Hepatocellular Carcinoma
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Villanueva
– volume: 24
  start-page: 1256
  year: 2023
  end-page: 1264
  ident: bb0265
  article-title: M(6)a RNA modification regulates innate lymphoid cell responses in a lineage-specific manner
  publication-title: Nat. Immunol.
  contributor:
    fullname: Huang
– volume: 34
  year: 2021
  ident: bb0100
  article-title: MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization
  publication-title: Cell Rep.
  contributor:
    fullname: Zhang
– volume: 16
  start-page: 589
  year: 2019
  end-page: 604
  ident: bb0010
  article-title: A global view of hepatocellular carcinoma: trends, risk, prevention and management
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  contributor:
    fullname: Roberts
– volume: 27
  start-page: 15
  year: 2022
  ident: bb0120
  article-title: The lncRNA DANCR promotes development of atherosclerosis by regulating the miR-214-5p/COX20 signaling pathway
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Zhang
– volume: 288
  start-page: 6174
  year: 2021
  end-page: 6186
  ident: bb0085
  article-title: Tumor-associated macrophages in immunotherapy
  publication-title: FEBS J.
  contributor:
    fullname: Wan
– volume: 6
  start-page: 692
  year: 2022
  end-page: 709
  ident: bb0295
  article-title: Role of hepatocyte-derived Osteopontin in liver carcinogenesis
  publication-title: Hepatol. Commun.
  contributor:
    fullname: Nieto
– volume: 28
  start-page: 33
  year: 2022
  ident: bb0180
  article-title: LncRNA LINC00461 exacerbates myocardial ischemia-reperfusion injury via microRNA-185-3p/Myd88
  publication-title: Mol. Med.
  contributor:
    fullname: Xu
– volume: 23
  start-page: 1208
  year: 2022
  end-page: 1221
  ident: bb0270
  article-title: The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
  publication-title: Nat. Immunol.
  contributor:
    fullname: Heissmeyer
– volume: 27
  start-page: 27
  year: 2022
  ident: bb0065
  article-title: Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Wang
– volume: 44
  year: 2016
  ident: bb0250
  article-title: SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Cui
– volume: 125
  start-page: 1640
  year: 2009
  end-page: 1648
  ident: bb0060
  article-title: Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
  publication-title: Int. J. Cancer
  contributor:
    fullname: Zheng
– volume: 148
  start-page: 1233
  year: 2021
  end-page: 1244
  ident: bb0090
  article-title: S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma
  publication-title: Int. J. Cancer
  contributor:
    fullname: Qin
– volume: 51
  year: 2017
  ident: bb0140
  article-title: Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage
  publication-title: Braz. J. Med. Biol. Res.
  contributor:
    fullname: Guo
– volume: 27
  start-page: 17
  year: 2022
  ident: bb0040
  article-title: Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Lu
– volume: 23
  start-page: 431
  year: 2022
  end-page: 445
  ident: bb0070
  article-title: PERK is a critical metabolic hub for immunosuppressive function in macrophages
  publication-title: Nat. Immunol.
  contributor:
    fullname: Huang
– volume: 23
  start-page: 1148
  year: 2022
  end-page: 1156
  ident: bb0045
  article-title: The complex role of tumor-infiltrating macrophages
  publication-title: Nat. Immunol.
  contributor:
    fullname: Boussiotis
– volume: 24
  start-page: 55
  year: 2023
  end-page: 68
  ident: bb0055
  article-title: SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses
  publication-title: Nat. Immunol.
  contributor:
    fullname: Boussiotis
– volume: 12
  year: 2022
  ident: bb0280
  article-title: Oviduct transcriptomic reveals the regulation of mRNAs and lncRNAs related to goat prolificacy in the luteal phase
  publication-title: Animals: Open Access J.MDPI
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 27
  year: 2021
  ident: bb0130
  article-title: LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Wang
– volume: 39
  start-page: 725
  year: 2021
  end-page: 729
  ident: bb0035
  article-title: Innate immune cells in the tumor microenvironment
  publication-title: Cancer Cell
  contributor:
    fullname: Bhardwaj
– volume: 288
  start-page: 803
  year: 2021
  end-page: 817
  ident: bb0080
  article-title: A C-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming
  publication-title: FEBS J.
  contributor:
    fullname: Sarangi
– volume: 27
  start-page: 22
  year: 2022
  ident: bb0310
  article-title: miR-152-3p impedes the malignant phenotypes of hepatocellular carcinoma by repressing roundabout guidance receptor 1
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Zhao
– volume: 19
  start-page: 820
  year: 2017
  end-page: 832
  ident: bb0170
  article-title: The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Sun
– volume: 27
  start-page: 51
  year: 2022
  ident: bb0210
  article-title: WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Tao
– volume: 12
  year: 2020
  ident: bb0290
  article-title: Osteopontin: a key regulator of tumor progression and immunomodulation
  publication-title: Cancers (Basel)
  contributor:
    fullname: Liu
– volume: 126
  start-page: 228
  year: 2022
  end-page: 237
  ident: bb0220
  article-title: Novel evidence for m(6)a methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer
  publication-title: Br. J. Cancer
  contributor:
    fullname: Goel
– volume: 20
  start-page: 46
  year: 2021
  ident: bb0095
  article-title: Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling
  publication-title: Mol. Cancer
  contributor:
    fullname: Liu
– volume: 68
  start-page: 1653
  year: 2019
  end-page: 1666
  ident: bb0105
  article-title: Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade
  publication-title: Gut
  contributor:
    fullname: Qin
– volume: 22
  start-page: 595
  year: 2021
  end-page: 606
  ident: bb0050
  article-title: Heme catabolism by tumor-associated macrophages controls metastasis formation
  publication-title: Nat. Immunol.
  contributor:
    fullname: Sica
– volume: 27
  start-page: 13
  year: 2022
  ident: bb0145
  article-title: SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Yin
– volume: 27
  start-page: 143
  year: 2021
  ident: bb0135
  article-title: LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family
  publication-title: Mol. Med.
  contributor:
    fullname: Guo
– volume: 27
  start-page: 55
  year: 2022
  ident: bb0215
  article-title: METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Ma
– volume: 39
  start-page: 632
  year: 2021
  end-page: 648 e638
  ident: bb0075
  article-title: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma
  publication-title: Cancer Cell
  contributor:
    fullname: Wu
– volume: 18
  start-page: 351
  year: 2019
  end-page: 362
  ident: bb0240
  article-title: lncRNA MAGI2-AS3 prevents the development of HCC via recruiting KDM1A and promoting H3K4me2 demethylation of the RACGAP1 promoter, Molecular therapy
  publication-title: Nucleic Acids
  contributor:
    fullname: Lu
– volume: 23
  start-page: 526
  year: 2021
  end-page: 537
  ident: bb0115
  article-title: LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Zou
– volume: 124
  start-page: 1621
  year: 2021
  end-page: 1622
  ident: bb0225
  article-title: RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance
  publication-title: Br. J. Cancer
  contributor:
    fullname: Priyadharsini
– volume: 126
  start-page: 1113
  year: 2022
  end-page: 1124
  ident: bb0150
  article-title: Long non-coding RNAs are involved in alternative splicing and promote cancer progression
  publication-title: Br. J. Cancer
  contributor:
    fullname: Xiong
– volume: 129
  start-page: 8
  year: 2023
  end-page: 23
  ident: bb0205
  article-title: The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy
  publication-title: Br. J. Cancer
  contributor:
    fullname: Zhang
– volume: 45
  start-page: W98
  year: 2017
  end-page: W102
  ident: bb0245
  article-title: GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 22
  year: 2021
  ident: bb0125
  article-title: LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Luo
– volume: 25
  start-page: 666
  year: 2014
  end-page: 681
  ident: bb0285
  article-title: A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma
  publication-title: Cancer Cell
  contributor:
    fullname: Sun
– volume: 28
  start-page: 2062
  year: 2012
  end-page: 2063
  ident: bb0255
  article-title: miRcode: a map of putative microRNA target sites in the long non-coding transcriptome
  publication-title: Bioinformatics
  contributor:
    fullname: Larsson
– volume: 26
  start-page: 6
  year: 2021
  ident: bb0155
  article-title: ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Zheng
– volume: 24
  start-page: 143
  year: 2023
  end-page: 160
  ident: bb0195
  article-title: Biological roles of adenine methylation in RNA
  publication-title: Nat. Rev. Genet.
  contributor:
    fullname: Greer
– volume: 13
  start-page: 102
  year: 2022
  ident: bb0235
  article-title: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1alpha/VEGF signaling
  publication-title: Cell Death Dis.
  contributor:
    fullname: Pu
– volume: 27
  start-page: 5
  year: 2022
  ident: bb0160
  article-title: LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Yuan
– volume: 50
  start-page: D165
  year: 2022
  end-page: D173
  ident: bb0260
  article-title: JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Mathelier
– volume: 26
  start-page: 49
  year: 2021
  ident: bb0020
  article-title: LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Zhang
– volume: 129
  start-page: 204
  year: 2023
  end-page: 221
  ident: bb0200
  article-title: RNA modifications in cancer
  publication-title: Br. J. Cancer
  contributor:
    fullname: Xiong
– volume: 525
  start-page: 33
  year: 2022
  end-page: 45
  ident: bb0305
  article-title: Long noncoding RNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop
  publication-title: Cancer Lett.
  contributor:
    fullname: Li
– volume: 54
  start-page: 2025
  year: 2011
  end-page: 2035
  ident: bb0315
  article-title: The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma
  publication-title: Hepatology
  contributor:
    fullname: Sun
– volume: 16
  start-page: 111
  year: 2017
  ident: bb0175
  article-title: Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling
  publication-title: Mol. Cancer
  contributor:
    fullname: Wang
– volume: 28
  start-page: 32
  year: 2023
  ident: bb0275
  article-title: KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating hippo-YAP pathway
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Wang
– volume: 16
  start-page: 1186
  year: 2020
  end-page: 1199
  ident: bb0300
  article-title: ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression
  publication-title: Autophagy
  contributor:
    fullname: Fan
– volume: 24
  start-page: 255
  year: 2023
  end-page: 266
  ident: bb0230
  article-title: YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells
  publication-title: Nat. Immunol.
  contributor:
    fullname: Yu
– volume: 283
  start-page: 3739
  year: 2016
  end-page: 3754
  ident: bb0190
  article-title: Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
  publication-title: FEBS J.
  contributor:
    fullname: Cheng
– volume: 47
  start-page: 199
  year: 2015
  end-page: 208
  ident: bb0110
  article-title: The landscape of long noncoding RNAs in the human transcriptome
  publication-title: Nat. Genet.
  contributor:
    fullname: Chinnaiyan
– volume: 24
  start-page: 238
  year: 2020
  end-page: 249
  ident: bb0320
  article-title: LncRNA HOXA11-AS regulates calcium oxalate crystal-induced renal inflammation via miR-124-3p/MCP-1
  publication-title: J. Cell. Mol. Med.
  contributor:
    fullname: Guo
– volume: 24
  start-page: 230
  year: 2022
  end-page: 241
  ident: bb0030
  article-title: Cancer-cell-derived GABA promotes beta-catenin-mediated tumour growth and immunosuppression
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Wang
– volume: 127
  start-page: 313
  year: 2022
  end-page: 320
  ident: bb0185
  article-title: Non-muscle-invasive micropapillary bladder cancer has a distinct lncRNA profile associated with unfavorable prognosis
  publication-title: Br. J. Cancer
  contributor:
    fullname: Bellmunt
– volume: 71
  start-page: 209
  year: 2021
  end-page: 249
  ident: bb0005
  article-title: Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J. Clin.
  contributor:
    fullname: Bray
– volume: 26
  start-page: 39
  year: 2021
  ident: bb0165
  article-title: Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Moghbeli
– volume: 125
  start-page: 865
  year: 2021
  end-page: 876
  ident: bb0025
  article-title: SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/beta-catenin/MYC/HMGCS2 axis
  publication-title: Br. J. Cancer
  contributor:
    fullname: Yuan
– volume: 39
  start-page: 725
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0035
  article-title: Innate immune cells in the tumor microenvironment
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.05.016
  contributor:
    fullname: Li
– volume: 27
  start-page: 55
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0215
  article-title: METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00349-1
  contributor:
    fullname: Zhang
– volume: 23
  start-page: 1208
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0270
  article-title: The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01268-1
  contributor:
    fullname: Ito-Kureha
– volume: 50
  start-page: D165
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0260
  article-title: JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab1113
  contributor:
    fullname: Castro-Mondragon
– volume: 288
  start-page: 6174
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0085
  article-title: Tumor-associated macrophages in immunotherapy
  publication-title: FEBS J.
  doi: 10.1111/febs.15726
  contributor:
    fullname: Yan
– volume: 24
  start-page: 143
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0195
  article-title: Biological roles of adenine methylation in RNA
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-022-00534-0
  contributor:
    fullname: Boulias
– volume: 127
  start-page: 313
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0185
  article-title: Non-muscle-invasive micropapillary bladder cancer has a distinct lncRNA profile associated with unfavorable prognosis
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-022-01799-2
  contributor:
    fullname: de Jong
– volume: 126
  start-page: 1113
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0150
  article-title: Long non-coding RNAs are involved in alternative splicing and promote cancer progression
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-021-01600-w
  contributor:
    fullname: Ouyang
– volume: 19
  start-page: 820
  year: 2017
  ident: 10.1016/j.clim.2024.109924_bb0170
  article-title: The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3538
  contributor:
    fullname: Yuan
– volume: 28
  start-page: 33
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0180
  article-title: LncRNA LINC00461 exacerbates myocardial ischemia-reperfusion injury via microRNA-185-3p/Myd88
  publication-title: Mol. Med.
  doi: 10.1186/s10020-022-00452-1
  contributor:
    fullname: Gao
– volume: 44
  year: 2016
  ident: 10.1016/j.clim.2024.109924_bb0250
  article-title: SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw104
  contributor:
    fullname: Zhou
– volume: 54
  start-page: 2025
  year: 2011
  ident: 10.1016/j.clim.2024.109924_bb0315
  article-title: The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma
  publication-title: Hepatology
  doi: 10.1002/hep.24606
  contributor:
    fullname: Yuan
– volume: 24
  start-page: 255
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0230
  article-title: YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01398-6
  contributor:
    fullname: Ma
– volume: 283
  start-page: 3739
  year: 2016
  ident: 10.1016/j.clim.2024.109924_bb0190
  article-title: Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
  publication-title: FEBS J.
  doi: 10.1111/febs.13839
  contributor:
    fullname: Zhu
– volume: 71
  start-page: 209
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0005
  article-title: Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21660
  contributor:
    fullname: Sung
– volume: 68
  start-page: 1653
  year: 2019
  ident: 10.1016/j.clim.2024.109924_bb0105
  article-title: Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade
  publication-title: Gut
  doi: 10.1136/gutjnl-2019-318419
  contributor:
    fullname: Zhu
– volume: 26
  start-page: 27
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0130
  article-title: LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00264-x
  contributor:
    fullname: Ni
– volume: 23
  start-page: 1148
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0045
  article-title: The complex role of tumor-infiltrating macrophages
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01267-2
  contributor:
    fullname: Christofides
– volume: 380
  start-page: 1450
  year: 2019
  ident: 10.1016/j.clim.2024.109924_bb0015
  article-title: Hepatocellular Carcinoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1713263
  contributor:
    fullname: Villanueva
– volume: 26
  start-page: 39
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0165
  article-title: Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00282-9
  contributor:
    fullname: Khalili-Tanha
– volume: 28
  start-page: 32
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0275
  article-title: KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating hippo-YAP pathway
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-023-00445-w
  contributor:
    fullname: Chen
– volume: 22
  start-page: 595
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0050
  article-title: Heme catabolism by tumor-associated macrophages controls metastasis formation
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-00921-5
  contributor:
    fullname: Consonni
– volume: 129
  start-page: 8
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0205
  article-title: The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-023-02246-6
  contributor:
    fullname: Diao
– volume: 27
  start-page: 15
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0120
  article-title: The lncRNA DANCR promotes development of atherosclerosis by regulating the miR-214-5p/COX20 signaling pathway
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00310-2
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 6
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0155
  article-title: ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00247-y
  contributor:
    fullname: Liu
– volume: 51
  year: 2017
  ident: 10.1016/j.clim.2024.109924_bb0140
  article-title: Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage
  publication-title: Braz. J. Med. Biol. Res.
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 22
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0125
  article-title: LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00269-6
  contributor:
    fullname: Zhou
– volume: 288
  start-page: 803
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0080
  article-title: A C-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming
  publication-title: FEBS J.
  doi: 10.1111/febs.15333
  contributor:
    fullname: Chakraborty
– volume: 6
  start-page: 692
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0295
  article-title: Role of hepatocyte-derived Osteopontin in liver carcinogenesis
  publication-title: Hepatol. Commun.
  doi: 10.1002/hep4.1845
  contributor:
    fullname: Desert
– volume: 24
  start-page: 1256
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0265
  article-title: M(6)a RNA modification regulates innate lymphoid cell responses in a lineage-specific manner
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-023-01548-4
  contributor:
    fullname: Zhang
– volume: 12
  year: 2020
  ident: 10.1016/j.clim.2024.109924_bb0290
  article-title: Osteopontin: a key regulator of tumor progression and immunomodulation
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers12113379
  contributor:
    fullname: Moorman
– volume: 16
  start-page: 589
  year: 2019
  ident: 10.1016/j.clim.2024.109924_bb0010
  article-title: A global view of hepatocellular carcinoma: trends, risk, prevention and management
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-019-0186-y
  contributor:
    fullname: Yang
– volume: 129
  start-page: 204
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0200
  article-title: RNA modifications in cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-023-02275-1
  contributor:
    fullname: Tang
– volume: 27
  start-page: 143
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0135
  article-title: LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family
  publication-title: Mol. Med.
  doi: 10.1186/s10020-021-00403-2
  contributor:
    fullname: Li
– volume: 126
  start-page: 228
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0220
  article-title: Novel evidence for m(6)a methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-021-01581-w
  contributor:
    fullname: Shimura
– volume: 26
  start-page: 49
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0020
  article-title: LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00295-4
  contributor:
    fullname: Xing
– volume: 24
  start-page: 55
  year: 2023
  ident: 10.1016/j.clim.2024.109924_bb0055
  article-title: SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01385-x
  contributor:
    fullname: Christofides
– volume: 12
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0280
  article-title: Oviduct transcriptomic reveals the regulation of mRNAs and lncRNAs related to goat prolificacy in the luteal phase
  publication-title: Animals: Open Access J.MDPI
  doi: 10.3390/ani12202823
  contributor:
    fullname: Sun
– volume: 24
  start-page: 230
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0030
  article-title: Cancer-cell-derived GABA promotes beta-catenin-mediated tumour growth and immunosuppression
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-021-00820-9
  contributor:
    fullname: Huang
– volume: 525
  start-page: 33
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0305
  article-title: Long noncoding RNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2021.10.033
  contributor:
    fullname: Xu
– volume: 27
  start-page: 17
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0040
  article-title: Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00309-9
  contributor:
    fullname: Lu
– volume: 27
  start-page: 27
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0065
  article-title: Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00325-9
  contributor:
    fullname: Gao
– volume: 13
  start-page: 102
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0235
  article-title: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1alpha/VEGF signaling
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-04505-5
  contributor:
    fullname: Wei
– volume: 27
  start-page: 13
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0145
  article-title: SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00313-z
  contributor:
    fullname: Wang
– volume: 23
  start-page: 526
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0115
  article-title: LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-021-00672-3
  contributor:
    fullname: Li
– volume: 25
  start-page: 666
  year: 2014
  ident: 10.1016/j.clim.2024.109924_bb0285
  article-title: A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.03.010
  contributor:
    fullname: Yuan
– volume: 27
  start-page: 5
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0160
  article-title: LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-021-00304-6
  contributor:
    fullname: Pan
– volume: 27
  start-page: 22
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0310
  article-title: miR-152-3p impedes the malignant phenotypes of hepatocellular carcinoma by repressing roundabout guidance receptor 1
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00322-y
  contributor:
    fullname: Yin
– volume: 125
  start-page: 1640
  year: 2009
  ident: 10.1016/j.clim.2024.109924_bb0060
  article-title: Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.24556
  contributor:
    fullname: Zhou
– volume: 34
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0100
  article-title: MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.108724
  contributor:
    fullname: Yuan
– volume: 18
  start-page: 351
  year: 2019
  ident: 10.1016/j.clim.2024.109924_bb0240
  article-title: lncRNA MAGI2-AS3 prevents the development of HCC via recruiting KDM1A and promoting H3K4me2 demethylation of the RACGAP1 promoter, Molecular therapy
  publication-title: Nucleic Acids
  doi: 10.1016/j.omtn.2019.08.020
  contributor:
    fullname: Pu
– volume: 24
  start-page: 238
  year: 2020
  ident: 10.1016/j.clim.2024.109924_bb0320
  article-title: LncRNA HOXA11-AS regulates calcium oxalate crystal-induced renal inflammation via miR-124-3p/MCP-1
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.14706
  contributor:
    fullname: Li
– volume: 125
  start-page: 865
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0025
  article-title: SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/beta-catenin/MYC/HMGCS2 axis
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-021-01490-y
  contributor:
    fullname: Li
– volume: 39
  start-page: 632
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0075
  article-title: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.02.013
  contributor:
    fullname: Braun
– volume: 148
  start-page: 1233
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0090
  article-title: S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.33371
  contributor:
    fullname: Wei
– volume: 23
  start-page: 431
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0070
  article-title: PERK is a critical metabolic hub for immunosuppressive function in macrophages
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01145-x
  contributor:
    fullname: Raines
– volume: 124
  start-page: 1621
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0225
  article-title: RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-021-01314-z
  contributor:
    fullname: Paramasivam
– volume: 20
  start-page: 46
  year: 2021
  ident: 10.1016/j.clim.2024.109924_bb0095
  article-title: Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-021-01343-5
  contributor:
    fullname: Zhao
– volume: 47
  start-page: 199
  year: 2015
  ident: 10.1016/j.clim.2024.109924_bb0110
  article-title: The landscape of long noncoding RNAs in the human transcriptome
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3192
  contributor:
    fullname: Iyer
– volume: 16
  start-page: 111
  year: 2017
  ident: 10.1016/j.clim.2024.109924_bb0175
  article-title: Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-017-0681-0
  contributor:
    fullname: Li
– volume: 45
  start-page: W98
  year: 2017
  ident: 10.1016/j.clim.2024.109924_bb0245
  article-title: GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx247
  contributor:
    fullname: Tang
– volume: 28
  start-page: 2062
  year: 2012
  ident: 10.1016/j.clim.2024.109924_bb0255
  article-title: miRcode: a map of putative microRNA target sites in the long non-coding transcriptome
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts344
  contributor:
    fullname: Jeggari
– volume: 16
  start-page: 1186
  year: 2020
  ident: 10.1016/j.clim.2024.109924_bb0300
  article-title: ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression
  publication-title: Autophagy
  doi: 10.1080/15548627.2019.1659614
  contributor:
    fullname: Li
– volume: 27
  start-page: 51
  year: 2022
  ident: 10.1016/j.clim.2024.109924_bb0210
  article-title: WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00350-8
  contributor:
    fullname: Lan
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Snippet Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N6-methyladenosine (m6A) also contributes to...
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SubjectTerms Crosstalk
Hepatocellular carcinoma
N6-methyladenosine
Positive feedback loop
Tumour-associated macrophage
Title METTL3/16-mediated m6A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells
URI https://dx.doi.org/10.1016/j.clim.2024.109924
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