Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model

• Published in: Drug metabolism and disposition Vol. 52; no. 11; pp. 1271 - 1287
• Main Authors: Guo, Zeyu, Gao, Jingjing, Liu, Li, Liu, Xiaodong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.10.2024
• Subjects: Adult; Area Under Curve; Computer Simulation; Digoxin - administration & dosage; Digoxin - pharmacokinetics; Exercise - physiology; Glomerular Filtration Rate - physiology; Heart Rate - physiology; Humans; Lidocaine - administration & dosage; Lidocaine - blood; Lidocaine - pharmacokinetics; Male; Midazolam - administration & dosage; Midazolam - pharmacokinetics; Models, Biological; Quinidine - pharmacokinetics; Ai; LogP; HRR; HR; Qha; A0; AUC; P; Q; CLint,gw,i; GFR; WB-PBPK; VO2; Kt:p; Qtotal; Rbp; fu,p; P-gp; Kt,i; Agw,i; CLkidney,int; Qsp; Peff; Tsf,i; Qst; Km,P-gp; Kmuscle:plasma; Papp; fu,b; CLliver,int; ri; Jmax; Ql

Exercise significantly alters human physiological functions, such as increasing cardiac output and muscle blood flow and decreasing glomerular filtration rate (GFR) and liver blood flow, thereby altering the absorption, distribution, metabolism, and excretion of drugs. In this study, we aimed to est...