Epidemiological pattern and time trends in testicular germ-cell tumors: a single institution 20-year experience
Recent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early stage cases. We analysed the time trends in biological features of these patients in order to confirm this tendency in our environment. The clinical recor...
Saved in:
Published in | Clinical & translational oncology Vol. 8; no. 8; pp. 588 - 593 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Italy
01.08.2006
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Recent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early stage cases. We analysed the time trends in biological features of these patients in order to confirm this tendency in our environment.
The clinical records of 136 consecutive patients with TGTs treated at a single institution over a 20-year period (1984-2003) were retrospectively reviewed. Pathological, clinical, therapeutic and outcome data were collected. Patients were allocated into four consecutive 5- year intervals and their characteristics were compared by means of the chi-squared test. The survival analysis was performed with the method of Kaplan and Meier.
A progressive increase in the incidence of new cases, and a more frequent diagnosis of stage I versus stage II-IV disease was confirmed within this time period. It was also observed a greater use of postorchiectomy chemotherapy, mainly due to an increase in the adjuvant indications. A significant decrease in the recurrence rate was noted. Ten-year overall survival was 86.5%. There was a trend for improved outcome, but the differences among the two decades were not statistically significant.
A real increase in the incidence of TGTs and in the proportion of early stages was confirmed. This may be due to an epidemiological change or to an earlier diagnosis. This new pattern is associated with a more frequent use of adjuvant chemotherapy and with a reduction in the relapse rate. |
---|---|
AbstractList | INTRODUCTIONRecent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early stage cases. We analysed the time trends in biological features of these patients in order to confirm this tendency in our environment. MATERIALS AND METHODSThe clinical records of 136 consecutive patients with TGTs treated at a single institution over a 20-year period (1984-2003) were retrospectively reviewed. Pathological, clinical, therapeutic and outcome data were collected. Patients were allocated into four consecutive 5- year intervals and their characteristics were compared by means of the chi-squared test. The survival analysis was performed with the method of Kaplan and Meier. RESULTSA progressive increase in the incidence of new cases, and a more frequent diagnosis of stage I versus stage II-IV disease was confirmed within this time period. It was also observed a greater use of postorchiectomy chemotherapy, mainly due to an increase in the adjuvant indications. A significant decrease in the recurrence rate was noted. Ten-year overall survival was 86.5%. There was a trend for improved outcome, but the differences among the two decades were not statistically significant. CONCLUSIONSA real increase in the incidence of TGTs and in the proportion of early stages was confirmed. This may be due to an epidemiological change or to an earlier diagnosis. This new pattern is associated with a more frequent use of adjuvant chemotherapy and with a reduction in the relapse rate. Recent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early stage cases. We analysed the time trends in biological features of these patients in order to confirm this tendency in our environment. The clinical records of 136 consecutive patients with TGTs treated at a single institution over a 20-year period (1984-2003) were retrospectively reviewed. Pathological, clinical, therapeutic and outcome data were collected. Patients were allocated into four consecutive 5- year intervals and their characteristics were compared by means of the chi-squared test. The survival analysis was performed with the method of Kaplan and Meier. A progressive increase in the incidence of new cases, and a more frequent diagnosis of stage I versus stage II-IV disease was confirmed within this time period. It was also observed a greater use of postorchiectomy chemotherapy, mainly due to an increase in the adjuvant indications. A significant decrease in the recurrence rate was noted. Ten-year overall survival was 86.5%. There was a trend for improved outcome, but the differences among the two decades were not statistically significant. A real increase in the incidence of TGTs and in the proportion of early stages was confirmed. This may be due to an epidemiological change or to an earlier diagnosis. This new pattern is associated with a more frequent use of adjuvant chemotherapy and with a reduction in the relapse rate. |
Author | Giménez Ortiz, Alejandra Molina Saera, Jorge Aparicio Urtasun, Jorge Ponce Lorenzo, José Montalar Salcedo, Joaquín Palomar Abad, Laura Díaz Beveridge, Roberto |
Author_xml | – sequence: 1 givenname: Jorge surname: Molina Saera fullname: Molina Saera, Jorge organization: Servicio de Oncología Médica, Hospital Universitario La Fe, Valencia, Spain – sequence: 2 givenname: Jorge surname: Aparicio Urtasun fullname: Aparicio Urtasun, Jorge – sequence: 3 givenname: Roberto surname: Díaz Beveridge fullname: Díaz Beveridge, Roberto – sequence: 4 givenname: Laura surname: Palomar Abad fullname: Palomar Abad, Laura – sequence: 5 givenname: Alejandra surname: Giménez Ortiz fullname: Giménez Ortiz, Alejandra – sequence: 6 givenname: José surname: Ponce Lorenzo fullname: Ponce Lorenzo, José – sequence: 7 givenname: Joaquín surname: Montalar Salcedo fullname: Montalar Salcedo, Joaquín |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16952847$$D View this record in MEDLINE/PubMed |
BookMark | eNpFkEtLxDAQx4OsuO7qB_AiOXmr5tU29SbL-oAFLwreSppOl0ib1CQF99ubsgsehhlmfvP6r9DCOgsI3VByTwkpHwJlpBIZIcVsImNn6JIWVZVxkueLU0yE_FqiVQjfJGULSi_QMhVyJkV5idx2NC0MxvVub7Tq8ahiBG-xsi2OZgAcPdg2YGNxhBCNnnrl8R78kGnoexynwfnwiBUOxu57SGCi4hSNs5iR7AAJh98RvAGr4Qqdd6oPcH3ya_T5vP3YvGa795e3zdMu04yKmOWK0JxxXrFGdVJWWoHWopOdYpQyyYtCp2RTQqmEbqRMj1VcJZC3rRRU8TW6O84dvfuZ0uH1YMJ8sLLgplAXUqZFBU8gPYLauxA8dPXozaD8oaaknlWujyrXSeHZRM1Sz-1p-NQM0P53nGTlfy2Ze14 |
CitedBy_id | crossref_primary_10_1111_bju_13844 crossref_primary_10_1590_S1677_5538_IBJU_2013_01_03 crossref_primary_10_1007_s00345_020_03437_z crossref_primary_10_1159_000488771 crossref_primary_10_1186_1897_4287_7_11 crossref_primary_10_1016_j_ajur_2023_05_002 crossref_primary_10_1159_000488284 crossref_primary_10_1186_s12885_021_08411_5 crossref_primary_10_1016_j_eururo_2008_09_027 |
Cites_doi | 10.1023/A:1018472530653 10.1016/S1470-2045(03)01278-6 10.1097/00042307-200311000-00009 10.1586/14737140.4.4.669 10.1002/ijc.21032 10.1002/ijc.20931 10.1016/S0022-5347(17)40007-3 10.1111/j.1464-410X.1987.tb04844.x 10.1097/01.ju.0000053866.68623.da 10.1586/14737140.5.1.123 10.1056/NEJM199707243370406 10.1002/1097-0142(19870501)59:9<1677::AID-CNCR2820590926>3.0.CO;2-Q 10.1200/JCO.1992.10.1.85 10.1200/JCO.1997.15.2.594 10.1038/bjc.1990.277 10.1007/s00345-004-0401-4 10.3109/02841868409136019 10.1016/S0302-2838(02)00439-6 10.1002/ijc.20088 10.1016/S1470-2045(03)01325-1 10.1002/1097-0215(20000801)87:3<438::AID-IJC20>3.0.CO;2-1 10.1046/j.1464-410x.1999.00072.x 10.1038/bjc.1989.25 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1007/s12094-006-0064-2 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1699-3055 |
EndPage | 593 |
ExternalDocumentID | 10_1007_s12094_006_0064_2 16952847 |
Genre | Journal Article |
GroupedDBID | -05 -0E -5E -5G -BR -EM -S~ -Y2 -~C .86 .VR 06C 06D 0R~ 0VY 1N0 203 29B 29~ 2B. 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 4.4 406 408 40D 40E 53G 5GY 5VR 5VS 67Z 6NX 8TC 8UJ 92I 92M 93N 95- 95. 95~ 96X AAAVM AABHQ AAFGU AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO ABAKF ABDZT ABECU ABFGW ABFTV ABHQN ABIPD ABJNI ABJOX ABKAS ABKCH ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABWNU ABXPI ACAOD ACBMV ACBRV ACBYP ACDTI ACGFS ACHSB ACHVE ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACTTH ACVWB ACWMK ACZOJ ADHIR ADINQ ADJJI ADKNI ADKPE ADMDM ADOXG ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFBBN AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG ARMRJ AXYYD B-. BA0 BDATZ BGNMA CAG CCEZO CGR CHBEP CIEJG COF CS3 CSCUP CUY CVF DDRTE DNIVK DPUIP EBLON EBS ECM EIF EIOEI EJD EN4 ESBYG F5P FA0 FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 HF~ HG5 HG6 HMJXF HRMNR HZ~ IJ- IKXTQ IMOTQ IWAJR IXD IZQ I~X I~Z J-C J0Z JBSCW JUIAU JZLTJ KOV KPH LLZTM M4Y MA- NPM NPVJJ NQJWS NU0 O9- O93 O9I O9J OAM P2P P9S PF0 PT4 Q-- Q-4 QOR QOS R89 R9I ROL RPX RSV RT5 S16 S1Z S27 S37 S3B SAP SDH SHX SISQX SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZ9 SZN T13 T8U TCJ TEORI TSG TSK TSV TT1 TUC U1F U1G U2A U5O U9L UG4 UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W48 WK8 YLTOR Z45 Z7D Z7U Z82 Z87 ZMTXR ZOVNA ~A9 ~N8 AACDK AAYXX CITATION H13 SJYHP 7X8 |
ID | FETCH-LOGICAL-c214t-5a01523392baf889caecc4f8fa21128366c89cb7e7a4cb8855693a8893dd841a3 |
ISSN | 1699-048X |
IngestDate | Sat Aug 17 02:12:52 EDT 2024 Thu Sep 12 18:04:03 EDT 2024 Thu May 23 23:12:36 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c214t-5a01523392baf889caecc4f8fa21128366c89cb7e7a4cb8855693a8893dd841a3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 16952847 |
PQID | 68821463 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_68821463 crossref_primary_10_1007_s12094_006_0064_2 pubmed_primary_16952847 |
PublicationCentury | 2000 |
PublicationDate | 2006-Aug |
PublicationDateYYYYMMDD | 2006-08-01 |
PublicationDate_xml | – month: 08 year: 2006 text: 2006-Aug |
PublicationDecade | 2000 |
PublicationPlace | Italy |
PublicationPlace_xml | – name: Italy |
PublicationTitle | Clinical & translational oncology |
PublicationTitleAlternate | Clin Transl Oncol |
PublicationYear | 2006 |
References | 15704170 - Int J Cancer. 2005 Jul 10;115(5):822-7 9227931 - N Engl J Med. 1997 Jul 24;337(4):242-53 12477650 - Eur Urol. 2002 Dec;42(6):553-62; discussion 562-3 15057561 - World J Urol. 2004 Apr;22(1):1 10444127 - BJU Int. 1999 Jul;84(1):68-74 9427433 - Cancer Causes Control. 1997 Nov;8(6):904-12 2757920 - Br J Cancer. 1989 Jan;59(1):126-8 2386743 - Br J Cancer. 1990 Aug;62(2):277-8 6093440 - Acta Radiol Oncol. 1984;23(4):239-47 15027129 - Int J Cancer. 2004 May 10;109(6):941-4 12796635 - J Urol. 2003 Jul;170(1):5-11 10897052 - Int J Cancer. 2000 Aug 1;87(3):438-43 15757445 - Expert Rev Anticancer Ther. 2005 Feb;5(1):123-38 14700610 - Lancet Oncol. 2004 Jan;5(1):56-61 2854295 - Semin Urol. 1988 Aug;6(3):171-88 2304163 - J Urol. 1990 Mar;143(3):520-3 1309383 - J Clin Oncol. 1992 Jan;10(1):85-94 9053482 - J Clin Oncol. 1997 Feb;15(2):594-603 14560141 - Curr Opin Urol. 2003 Nov;13(6):473-6 14662429 - Lancet Oncol. 2003 Dec;4(12):730-7 3594102 - Br J Urol. 1987 May;59(5):447-51 14662430 - Lancet Oncol. 2003 Dec;4(12):738-47 15818625 - Int J Cancer. 2005 Sep 1;116(3):331-9 15270670 - Expert Rev Anticancer Ther. 2004 Aug;4(4):669-77 3828968 - Cancer. 1987 May 1;59(9):1677-82 E Huyghe (88588_CR2) 2003; 170 GM Mead (88588_CR21) 1992; 10 CED Chilvers (88588_CR24) 1989; 59 DJ Sonneveld (88588_CR8) 1999; 84 P Hermanek (88588_CR9) 1997 A Pettersson (88588_CR18) 2004; 109 RH Jones (88588_CR5) 2003; 4 RH Jones (88588_CR7) 2003; 4 JR Germá-Lluch (88588_CR13) 2002; 42 P Boyle (88588_CR12) 2004; 5 RA Huddard (88588_CR11) 2005; 5 N Pearce (88588_CR15) 1987; 59 K Heimdal (88588_CR19) 1990; 62 MJ Garner (88588_CR1) 2005; 116 HK Weir (88588_CR17) 2000; 87 G Krag Jacobsen (88588_CR20) 1984; 23 International Germ Cell Cancer Collaborative Group (88588_CR10) 1997; 15 H Moller (88588_CR16) 1997; 8 M Kuczyc (88588_CR25) 2004; 22 JW Moul (88588_CR22) 1990; 143 JA Thornhill (88588_CR23) 1987; 59 MP Purdue (88588_CR3) 2005; 115 M Scholz (88588_CR6) 2003; 13 FK Mostofi (88588_CR14) 1988; 6 GJ Bosl (88588_CR4) 1997; 337 C Balk (88588_CR26) 2004; 4 |
References_xml | – volume: 8 start-page: 904 year: 1997 ident: 88588_CR16 publication-title: Cancer Causes Control. doi: 10.1023/A:1018472530653 contributor: fullname: H Moller – volume: 4 start-page: 730 year: 2003 ident: 88588_CR5 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(03)01278-6 contributor: fullname: RH Jones – volume: 13 start-page: 473 year: 2003 ident: 88588_CR6 publication-title: Curr Opin Urol. doi: 10.1097/00042307-200311000-00009 contributor: fullname: M Scholz – volume: 4 start-page: 669 year: 2004 ident: 88588_CR26 publication-title: Expert Rev Anticancer Ther. doi: 10.1586/14737140.4.4.669 contributor: fullname: C Balk – volume: 116 start-page: 331 year: 2005 ident: 88588_CR1 publication-title: Int J Cancer. doi: 10.1002/ijc.21032 contributor: fullname: MJ Garner – volume: 115 start-page: 822 year: 2005 ident: 88588_CR3 publication-title: Int J Cancer. doi: 10.1002/ijc.20931 contributor: fullname: MP Purdue – volume: 143 start-page: 520 year: 1990 ident: 88588_CR22 publication-title: J Urol. doi: 10.1016/S0022-5347(17)40007-3 contributor: fullname: JW Moul – volume: 59 start-page: 447 year: 1987 ident: 88588_CR23 publication-title: Br J Urol. doi: 10.1111/j.1464-410X.1987.tb04844.x contributor: fullname: JA Thornhill – volume: 170 start-page: 5 year: 2003 ident: 88588_CR2 publication-title: J Urol. doi: 10.1097/01.ju.0000053866.68623.da contributor: fullname: E Huyghe – volume: 6 start-page: 171 year: 1988 ident: 88588_CR14 publication-title: Semin Urol. contributor: fullname: FK Mostofi – volume: 5 start-page: 123 year: 2005 ident: 88588_CR11 publication-title: Expert Rev Anticancer Ther. doi: 10.1586/14737140.5.1.123 contributor: fullname: RA Huddard – volume: 337 start-page: 242 year: 1997 ident: 88588_CR4 publication-title: New Engl J Med. doi: 10.1056/NEJM199707243370406 contributor: fullname: GJ Bosl – volume: 59 start-page: 1677 year: 1987 ident: 88588_CR15 publication-title: Cancer. doi: 10.1002/1097-0142(19870501)59:9<1677::AID-CNCR2820590926>3.0.CO;2-Q contributor: fullname: N Pearce – volume: 4 start-page: 758 year: 2003 ident: 88588_CR7 publication-title: Lancet Oncol. contributor: fullname: RH Jones – volume: 10 start-page: 85 year: 1992 ident: 88588_CR21 publication-title: J Clin Oncol. doi: 10.1200/JCO.1992.10.1.85 contributor: fullname: GM Mead – volume: 15 start-page: 594 year: 1997 ident: 88588_CR10 publication-title: J Clin Oncol. doi: 10.1200/JCO.1997.15.2.594 contributor: fullname: International Germ Cell Cancer Collaborative Group – volume: 62 start-page: 277 year: 1990 ident: 88588_CR19 publication-title: Br J Cancer. doi: 10.1038/bjc.1990.277 contributor: fullname: K Heimdal – volume: 22 start-page: 1 year: 2004 ident: 88588_CR25 publication-title: World J Urol. doi: 10.1007/s00345-004-0401-4 contributor: fullname: M Kuczyc – volume: 23 start-page: 239 year: 1984 ident: 88588_CR20 publication-title: Acta Radiol Oncol. doi: 10.3109/02841868409136019 contributor: fullname: G Krag Jacobsen – volume: 42 start-page: 553 year: 2002 ident: 88588_CR13 publication-title: Eur Urol. doi: 10.1016/S0302-2838(02)00439-6 contributor: fullname: JR Germá-Lluch – volume: 109 start-page: 941 year: 2004 ident: 88588_CR18 publication-title: Int J Cancer. doi: 10.1002/ijc.20088 contributor: fullname: A Pettersson – volume: 5 start-page: 56 year: 2004 ident: 88588_CR12 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(03)01325-1 contributor: fullname: P Boyle – volume: 87 start-page: 438 year: 2000 ident: 88588_CR17 publication-title: Int J Cancer. doi: 10.1002/1097-0215(20000801)87:3<438::AID-IJC20>3.0.CO;2-1 contributor: fullname: HK Weir – volume: 84 start-page: 68 year: 1999 ident: 88588_CR8 publication-title: BJU Int. doi: 10.1046/j.1464-410x.1999.00072.x contributor: fullname: DJ Sonneveld – volume-title: UICC: TNM Classification of Malignant Tumours year: 1997 ident: 88588_CR9 contributor: fullname: P Hermanek – volume: 59 start-page: 126 year: 1989 ident: 88588_CR24 publication-title: Br J Cancer. doi: 10.1038/bjc.1989.25 contributor: fullname: CED Chilvers |
SSID | ssj0055611 |
Score | 1.7825742 |
Snippet | Recent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early stage cases.... INTRODUCTIONRecent studies have suggested a rise in the incidence of testicular germ-cell tumors (TGTs) in the last years, mainly due to an increase of early... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 588 |
SubjectTerms | Adolescent Adult Early Diagnosis Humans Incidence Male Middle Aged Neoplasm Staging Neoplasms, Germ Cell and Embryonal - epidemiology Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Germ Cell and Embryonal - therapy Retrospective Studies Survival Analysis Testicular Neoplasms - epidemiology Testicular Neoplasms - pathology Testicular Neoplasms - therapy |
Title | Epidemiological pattern and time trends in testicular germ-cell tumors: a single institution 20-year experience |
URI | https://www.ncbi.nlm.nih.gov/pubmed/16952847 https://search.proquest.com/docview/68821463 |
Volume | 8 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9swEBYhe-mltPSVbh869NTFxbEkW-4t-2IpdC_dwN6MLEulkLWXxD50_2T_UmcsKXbSLnR7CUEOiq35GH0az3xDyIfEWhS9M5GwsY24sCbKNUujMp5rJkwJWxrGIb9ephdL_uVaXE8mv0ZZS11bftJ3f60r-R-rwhjYFatkH2DZ7aQwAN_BvvAJFobPf7Lx2dDetV_r214s06UXY9N4TCP3Ga8tqmm4nNPv4IwjDNgftd1Ns964emeMGaxQQcQlDyAq4Mj3E3V-zFYOeUxlT0JNJYKnxS1vFQKLTa13ovXflFm7nFwMwIMfWfmm3XhxCfx_09XD5QU2RtQuP8yVEIFhQg94lwneHJ32b_hP1d3w_sqBFQu9FRDjVXOj1vsxDRliGs4Np6iNwPumw7BLDWOoTzb23XIEUTnyw8L1CvRbunBNGP_YLWJfPZ3EqI-MtwEEzVdj7ihz7-2Y2zzGQfMZpyhcjmDKC-AEB0mWi2xKDhbnx8eXgRxgM9I-BhAeMLxo76s59-5jlyrdc_7pedDVE_LYH2DowqHxKZmY-hlp9pBIPRIpIJEiEqlDIv1R0wGJdItE6pD4mSrqcEhHOKQeh3TA4XOyPD-7OrmIfCuPSCdz3kZCAe1MGJDxUlkpc63AdXArrUqA8EuWphoGy8xkiutSSlinnCn4IasqyeeKvSDTuqnNK0IrJjLLY6NYlXBbCam0yRUTqFxZwZwz8jGsWnHrFFuKe-00I-_DuhbgV_GJVW2ablOkcPQEFsFm5KVb7mGyNBdI6l4_5I8OyaMB6G_ItF135i3Q2bZ85yHyG0dqoK0 |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Library Specific Holdings |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epidemiological+pattern+and+time+trends+in+testicular+germ-cell+tumors%3A+a+single+institution+20-year+experience&rft.jtitle=Clinical+%26+translational+oncology&rft.au=Saera%2C+Jorge+Molina&rft.au=Urtasun%2C+Jorge+Aparicio&rft.au=Beveridge%2C+Roberto+D%C3%ADaz&rft.au=Abad%2C+Laura+Palomar&rft.date=2006-08-01&rft.issn=1699-048X&rft.eissn=1699-3055&rft.volume=8&rft.issue=8&rft.spage=588&rft.epage=593&rft_id=info:doi/10.1007%2Fs12094-006-0064-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s12094_006_0064_2 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1699-048X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1699-048X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1699-048X&client=summon |