Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases

• Published in: Theranostics Vol. 8; no. 1; pp. 292 - 303
• Main Authors: Falzone, Nadia, Ackerman, Nicole L., Rosales, Liset de la Fuente, Bernal, Mario A., Liu, Xiaoxuan, Peeters, Sarah GJA, Soto, Manuel Sarmiento, Corroyer-Dulmont, Aurélien, Bernaudin, Myriam, Grimoin, Elisa, Touzani, Omar, Sibson, Nicola R., Vallis, Katherine A.
• Format: Journal Article
• Language: English
• Published: Ivyspring International Publisher 2018
• Subjects: Cancer; Human health and pathology; Life Sciences; Neurons and Cognition

Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treat...