Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell–mediated liver regeneration

• Published in: Hepatology (Baltimore, Md.) Vol. 45; no. 6; pp. 1462 - 1470
• Main Authors: Jelnes, Peter, Santoni‐Rugiu, Eric, Rasmussen, Morten, Friis, Susanne Lunøe, Nielsen, Jens Høiriis, Tygstrup, Niels, Bisgaard, Hanne Cathrine
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2007
• Subjects: alpha-Fetoproteins - genetics; alpha-Fetoproteins - metabolism; Animals; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Biomarkers - metabolism; Cell Lineage - physiology; Female; Immunohistochemistry; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Keratins - metabolism; Liver - cytology; Liver - physiology; Liver Regeneration - physiology; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Models, Animal; Phenotype; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; Rats; Rats, Inbred F344; RNA, Messenger - metabolism; Stem Cells - cytology; Stem Cells - physiology

The experimental protocols used in the investigation of stem cell–mediated liver regeneration in rodents are characterized by activation of the hepatic stem cell compartment in the canals of Hering followed by transit amplification of oval cells and their subsequent differentiation along hepatic lin...