Phenotype and gene signature of testicular tumors in 129.MOLF-Chr19 mice resemble human teratomas

• Published in: Andrology (Oxford)
• Main Authors: Gayer, Fabian A, Klaus, Lucas, Reichardt, Sybille D, Fichtner, Alexander, Reichardt, Holger M
• Format: Journal Article
• Language: English
• Published: England 29.07.2024
• Subjects: 129.MOLF‐Chr19; teratoma; mice; testicular germ cell tumor; gene expression

Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal-type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal-type teratomas arise independently of the GCNIS. The consomic mouse strain 129...