Selective activation of the M 1 muscarinic acetylcholine receptor achieved by allosteric potentiation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 37; pp. 15950 - 15955
• Main Authors: Ma, Lei, Seager, Matthew A., Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W., Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R., Ray, William J.
• Format: Journal Article
• Language: English
• Published: 15.09.2009

The forebrain cholinergic system promotes higher brain function in part by signaling through the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M 1 receptors could improve cognitive function...