β2-Adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms

• Published in: Archives of biochemistry and biophysics Vol. 482; no. 1; pp. 96 - 103
• Main Authors: Aitken, Sarah J., Landao-Bassonga, Euphemie, Ralston, Stuart H., Idris, Aymen I.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.02.2009
• Subjects: Adrenoceptors; Bone; Catecholamine; Isoprenaline; Noradrenaline; Osteoblast; Osteoclast; Isoprenaline; Adrenoceptors; Osteoblast; Osteoclast; Bone; Catecholamine; Noradrenaline

Pharmacological modulators of β-adrenoceptors can influence bone mineral density and fracture risk in humans. Studies reported that β-adrenoceptor ligands stimulate bone resorption by enhancing the expression of RANK-L, whereas the mechanisms by which β-adrenoreceptors regulate bone formation are po...