Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O 2 affinity

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 276; no. 2; pp. H553 - H562
• Main Authors: Sakai, Hiromi, Tsai, Amy G, Rohlfs, Ronald J, Hara, Hiroyuki, Takeoka, Shinji, Tsuchida, Eishun, Intaglietta, Marcos
• Format: Journal Article
• Language: English
• Published: United States 01.02.1999
• Subjects: oxygen carrier; autoregulation; microcirculation; liposome; oxygen dissociation curve

Phospholipid vesicles encapsulating purified hemoglobin (HbV) were developed to provide O -carrying capacity to plasma expanders. Microvascular perfusion was determined for HbV with different O affinity (P = 9, 16, and 30 mmHg) prepared by coencapsulating pyridoxal 5'-phosphate (PLP) at the mol...