ICAM1 778G>A (rs1799969), ADD1 1378G>T (rs4961), NPPA 553T>C (rs5065), and NOS3 894G>T (rs1799983) Variants in Infants with Gastroschisis from Western Mexico

• Published in: Genetic testing and molecular biomarkers Vol. 29; no. 6; p. 139
• Main Authors: Bobadilla Morales, Lucina, Mellín-Sánchez, Estrella Lizbeth, Robledo-Aceves, Mireya, Corona-Rivera, Alfredo, Orozco-Vela, Mireya, Velasco, Juan José Cárdenas-Ruiz, Ramirez-Corona, Juan Antonio, Cruz-Cruz, Jessica Paola, Martínez-Torres, Ana Fátima, Corona-Rivera, Jorge Román
• Format: Journal Article
• Language: English
• Published: United States 01.06.2025
• Subjects: Alleles; Case-Control Studies; Female; Gastroschisis - genetics; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genotype; Humans; Infant; Infant, Newborn; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Male; Mexico; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Polymorphism, Single Nucleotide - genetics; Risk Factors; Mexico; gastroschisis; NOS3; ADD1; NPPA; ICAM1

Gene variants of (rs1799969), (rs4961), (rs5065), and (rs1799983) have been proposed as possible genetic risk factors for vascular compromise in gastroschisis. However, this interpretation is questionable because the vascular disruption theory is now considered unlikely. According to current knowled...