Level of Expression of IL-13Rα2 Impacts Receptor Distribution and IL-13 Signaling

• Published in: The Journal of immunology (1950) Vol. 176; no. 12; pp. 7495 - 7501
• Main Authors: Daines, Michael O., Tabata, Yasuhiro, Walker, Bradley A., Chen, Weiguo, Warrier, Manoj R., Basu, Saswata, Hershey, Gurjit K. Khurana
• Format: Journal Article
• Language: English
• Published: 15.06.2006

Abstract IL-13, a critical cytokine for allergic inflammation, exerts its effects through a complex receptor system including IL-4Rα, IL-13Rα1, and IL-13Rα2. IL-4Rα and IL-13Rα1 form a heterodimeric signaling receptor for IL-13. In contrast, IL-13Rα2 binds IL-13 with high affinity but does not signa...