Interactions between Brain-Derived Neurotrophic Factor Val66Met Genotype and Sex Affect Hippocampal Regional Cerebral Blood Flow during Rest

• Published in: NeuroImage (Orlando, Fla.) Vol. 47; p. S161
• Main Authors: Wei, S-M, Padmanabhan, A, Kohn, P.D., Kolachana, B, Weinberger, D.R., Berman, K.F.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2009; Elsevier Limited
• Subjects: Blood flow; Brain-derived neurotrophic factor; Cerebral blood flow; Gender differences; Genotype & phenotype; Genotypes; Hippocampus; Polymorphism

Introduction The val66met single nucleotide polymorphism (SNP) in the human brain-derived neurotrophic factor (BDNF) gene influences hippocampal function, with the met allele being associated with abnormal hippocampal recruitment during episodic1 and working2 memory. Because BDNF and gonadal steroid...