Oncologic outcomes of squamous cell carcinoma of the anal canal after chemoradiation therapy

• Published in: Korean journal of clinical oncology Vol. 12; no. 1; pp. 41 - 47
• Main Authors: Lim, Dae Ro, Hur, Hyuk, Min, Byung Soh, Baik, Seung Hyuk, Lee, Kang Young, Kim, Nam Kyu
• Format: Journal Article
• Language: English
• Published: 대한종양외과학회 01.06.2016; Korean Society of Surgical Oncology
• Subjects: anal neoplasms; chemoradiotherapy; squamous cell carcinoma; Chemoradiotherapy; Squamous cell carcinoma; Anal neoplasms
• ISSN: 1738-8082; 2288-4084
• DOI: 10.14216/kjco.16007

Purpose The aim of this study is to analyze the oncological outcomes of squamous cell carcinoma (SCC) of the anal canal after chemoradiation therapy (CRT) in a single institution. Methods Fifty-one patients with anal SCC who had been treated with CRT between January 2000 and December 2010 were analyze data single center in Korea. Results Forty-eight patients exhibited clinical complete response. After a median follow-up of 42.1 months, 13 patients (25.5%) showed recurrence. The disease-free survival (DFS) rate was 63.4% at 5 and 10 years. The overall survival (OS) rates were 83.6% (5 years) and 75.2% (10 years). Stage I: DFS, 100%; OS, 100%; stage II: DFS, 85.7%; OS, 100%; stage IIIA: DFS, 68.6%; OS, 87.5%; stage IIIB: DFS, 34.7%; OS, 48.4%; and stage IV: DFS and OS, 0%. The local recurrence patterns were as follows: pelvic node (n=4, 7.8%), inguinal node (n=1, 2.0%), and inguinal and pelvic node (n=1, 2.0%). The systemic recurrence patterns were as follows: lung (n=2, 3.9%), para-aortic node (n=1, 2.0%), and extrapelvic site (n=2, 3.9%). N-stage represented a single independent prognostic factor for recurrence (P<0.05). Conclusion CRT for SCC of the anal canal is effective for oncological outcomes and sphincter preservation. The initial nodal status may affect the oncological outcome.