Comprehensive Analysis of the Tumour Immune Microenvironment in Canine Urothelial Carcinoma Reveals Immunosuppressive Mechanisms Induced by the COX-Prostanoid Cascade

• Published in: Veterinary & comparative oncology
• Main Authors: Eto, Shotaro, Kato, Daiki, Saeki, Kohei, Iguchi, Takaaki, Shiyu, Qin, Kamoto, Satoshi, Yoshitake, Ryohei, Shinada, Masahiro, Ikeda, Namiko, Tsuboi, Masaya, Chambers, James, Uchida, Kazuyuki, Nishimura, Ryohei, Nakagawa, Takayuki
• Format: Journal Article
• Language: English
• Published: England 23.08.2024
• Subjects: tumour immune microenvironment (TIME); canine urothelial carcinoma (cUC); cyclooxygenase (COX); microsomal prostaglandin E synthase‐2 (mPGES‐2)

A comprehensive understanding of the tumour immune microenvironment (TIME) is essential for advancing precision medicine and identifying potential therapeutic targets. This study focused on canine urothelial carcinoma (cUC) recognised for its high sensitivity to cyclooxygenase (COX) inhibitors. Usin...