Mammal-specific, ERK-dependent, Caldesmon Phosphorylation in Smooth Muscle

• Published in: The Journal of biological chemistry Vol. 274; no. 42; pp. 30115 - 30121
• Main Authors: D'Angelo, Gerard, Graceffa, Philip, Wang, C.-L. Albert, Wrangle, John, Adam, Leonard P.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.1999; American Society for Biochemistry and Molecular Biology

Extracellular signal-regulated kinases (ERKs) phosphorylate the high molecular mass isoform of the actin-binding protein caldesmon (h-CaD) at two sites (Ser759 and Ser789) during smooth muscle stimulation. To investigate the role of phosphorylation at these sites, antibodies were generated against p...