Simultaneous release of two drugs from polymer nano-implant inhibits recurrence in glioblastoma spheroids

• Published in: Precision nanomedicine Vol. 2; no. 1; pp. 218 - 229
• Main Authors: Devassy, Greeshma, Ramachandran, Ranjith, Jeena, Kottarapat, Junnuthula, Vijayabhaskar R, Gopinatha, Vindya K, Manju, Cheripelil, Manohar, Maneesh, Nair, Shantikumar V., Raghavan, Sathees C, Koyakutty, Manzoor
• Format: Journal Article
• Language: English
• Published: 01.02.2019

Local implant-based delivery of rationally selected combination of chemotherapeutics has some major advantages for the treatment of glioblastoma such as: (a) 100 % bio-availability locally in brain can be achieved at the tumor site (b) avoid systemic leakage and associated toxicity, and (c) simultan...