The heterotrimeric Gα protein Pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum

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Published inMicrobiology (Society for General Microbiology) Vol. 154; no. 11; pp. 3567 - 3578
Main Authors García-Rico, Ramón O., Fierro, Francisco, Mauriz, Elba, Gómez, Ana, Fernández-Bodega, María Ángeles, Martín, Juan F.
Format Journal Article
LanguageEnglish
Published Reading Society for General Microbiology 01.11.2008
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene expression
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
Molecular and cellular biology
Molecular genetics
Mycology
Fungi
Penicillin
Cyclic AMP
Biosynthesis
Roquefortine
Fungi Imperfecti
Intracellular
Penicillium chrysogenum
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Author García-Rico, Ramón O.
Mauriz, Elba
Martín, Juan F.
Fernández-Bodega, María Ángeles
Fierro, Francisco
Gómez, Ana
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  givenname: María Ángeles
  surname: Fernández-Bodega
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  fullname: Martín, Juan F.
  organization: Área de Microbiología, Fac. CC. Biológicas y Ambientales, Universidad de León, León 24071, Spain, Instituto de Biotecnología de León, INBIOTEC, Parque Científico de León, León 24006, Spain
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Cites_doi 10.1128/AEM.20.5.839-842.1970
10.1128/MMBR.64.4.746-785.2000
10.1016/S0958-1669(97)80072-9
10.1007/s002530051249
10.1093/emboj/16.16.4916
10.7164/antibiotics.57.502
10.1038/nature04300
10.1007/BF00172491
10.1146/annurev.micro.61.080706.093432
10.1038/nature04341
10.1074/jbc.273.2.669
10.1146/annurev.phyto.43.040204.140214
10.1093/genetics/151.1.107
10.1128/AEM.46.6.1301-1310.1983
10.1038/nrmicro1286
10.1146/annurev.bi.61.070192.005313
10.1099/mic.0.2007/012260-0
10.1146/annurev.mi.46.100192.002333
10.1099/13500872-145-2-317
10.1016/j.fgb.2006.03.001
10.1023/A:1005694415666
10.1128/MMBR.66.3.447-459.2002
10.1006/fgbi.1998.1102
10.1016/S0021-9673(03)00490-4
10.1002/j.1460-2075.1996.tb00903.x
10.1128/JB.181.4.1181-1188.1999
10.1016/j.fgb.2005.04.009
10.1046/j.1365-2958.2000.02166.x
10.1534/genetics.103.025379
10.1007/s00253-003-1274-y
10.1039/B603084J
10.1139/O07-148
10.1073/pnas.92.13.6200
10.1074/jbc.275.4.2423
10.1016/0092-8674(95)90407-7
10.1046/j.1365-2958.1996.5421065.x
10.1038/nature04332
10.1093/genetics/157.2.591
10.1128/MMBR.62.3.547-585.1998
10.1128/JB.182.9.2355-2362.2000
10.1128/EC.1.3.440-447.2002
10.1016/S0168-1605(03)00291-5
10.1016/j.fgb.2007.03.008
10.1016/j.resmic.2007.03.001
10.1007/s11046-007-0091-8
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Issue 11
Keywords Fungi
Penicillin
Cyclic AMP
Biosynthesis
Roquefortine
Fungi Imperfecti
Intracellular
Penicillium chrysogenum
Language English
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References Machida (R30) 2005; 438
Zuber (R49) 2002; 1
Rundberget (R38) 2004; 90
van den Berg (R43) 2007; 44
Yu (R46) 1996; 15
Martín (R32) 2000; 182
Elander (R10) 2003; 61
Keller (R24) 2005; 3
Kosalkova (R25) 2000; 275
Lengeler (R27) 2000; 64
García-Rico (R17) 2007; 158
Bohm (R3) 1997; 8
Galagan (R16) 2005; 438
Asilonu (R2) 2000; 22
Tag (R42) 2000; 38
Calvo (R6) 2002; 66
Fierro (R12) 1996; 44
Hamm (R20) 1998; 273
Aharonowitz (R1) 1992; 46
Chang (R8) 2004; 167
García-Rico (R18) 2008; 86
Fierro (R14) 2006; 43
Yu (R47) 2008; 154
Fierro (R11) 1995; 92
Li (R28) 2007; 61
Metsä-Ketelä (R33) 2004; 57
Bölker (R4) 1998; 25
de la Campa (R9) 2007; 163
Fierro (R13) 2002
Reithner (R37) 2005; 42
Shimizu (R40) 2001; 15
Brakhage (R5) 1998; 62
Frisvad (R15) 1983; 46
Neer (R34) 1995; 80
Liras (R29) 2006; 9
Martín (R31) 1998; 50
Suárez (R41) 1996; 20
Casqueiro (R7) 1999; 181
Hoffmeister (R22) 2007; 24
Kurjan (R26) 1992; 61
Yu (R45) 2005; 43
Gutiérrez (R19) 1999; 145
Hicks (R21) 1997; 16
Nielsen (R35) 2003; 1002
Zhang (R48) 2004
Yang (R44) 1999; 151
Nierman (R36) 2005; 438
Scott (R39) 1970; 20
References_xml – volume: 20
  start-page: 839
  year: 1970
  ident: R39
  article-title: Detection of mycotoxins by thin-layer chromatography: application to screening of fungal extracts
  publication-title: Appl Microbiol
  doi: 10.1128/AEM.20.5.839-842.1970
– volume: 64
  start-page: 746
  year: 2000
  ident: R27
  article-title: Signal transduction cascades regulating fungal development and virulence
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.64.4.746-785.2000
– volume: 8
  start-page: 480
  year: 1997
  ident: R3
  article-title: Structural aspects of heterotrimeric G-protein signaling
  publication-title: Curr Opin Biotechnol
  doi: 10.1016/S0958-1669(97)80072-9
– start-page: 179
  volume-title: Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation
  year: 2002
  ident: R13
  article-title: Sulfur-containing β-lactam antibiotics: enzymes, genes and regulation of the biosynthesis
– volume: 50
  start-page: 1
  year: 1998
  ident: R31
  article-title: New aspects of genes and enzymes for β-lactam antibiotic biosynthesis
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/s002530051249
– volume: 16
  start-page: 4916
  year: 1997
  ident: R21
  article-title: Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway
  publication-title: EMBO J
  doi: 10.1093/emboj/16.16.4916
– volume: 57
  start-page: 502
  year: 2004
  ident: R33
  article-title: Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64
  publication-title: J Antibiot (Tokyo)
  doi: 10.7164/antibiotics.57.502
– volume: 9
  start-page: 9
  year: 2006
  ident: R29
  article-title: Gene clusters for β-lactam antibiotics and control of their expression: why have clusters been formed and where do they come from?
  publication-title: Int Microbiol
– volume: 438
  start-page: 1157
  year: 2005
  ident: R30
  article-title: Genome sequencing and analysis of Aspergillus oryzae
  publication-title: Nature
  doi: 10.1038/nature04300
– volume: 44
  start-page: 597
  year: 1996
  ident: R12
  article-title: Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/BF00172491
– volume: 61
  start-page: 423
  year: 2007
  ident: R28
  article-title: Heterotrimeric G protein signaling in filamentous fungi
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev.micro.61.080706.093432
– volume: 438
  start-page: 1105
  year: 2005
  ident: R16
  article-title: Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
  publication-title: Nature
  doi: 10.1038/nature04341
– volume: 273
  start-page: 669
  year: 1998
  ident: R20
  article-title: The many faces of G protein signaling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.2.669
– volume: 43
  start-page: 437
  year: 2005
  ident: R45
  article-title: Regulation of secondary metabolism in filamentous fungi
  publication-title: Annu Rev Phytopathol
  doi: 10.1146/annurev.phyto.43.040204.140214
– volume: 151
  start-page: 107
  year: 1999
  ident: R44
  article-title: Mutational activation of a G α i causes uncontrolled proliferation of aerial hyphae and increased sensitivity to heat and oxidative stress in Neurospora crassa
  publication-title: Genetics
  doi: 10.1093/genetics/151.1.107
– start-page: 355
  volume-title: Handbook of Industrial Microbiology
  year: 2004
  ident: R48
  article-title: Secondary metabolite gene clusters
– volume: 46
  start-page: 1301
  year: 1983
  ident: R15
  article-title: Classification of terverticillate penicillia based on profiles of mycotoxins and other secondary metabolites
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.46.6.1301-1310.1983
– volume: 3
  start-page: 937
  year: 2005
  ident: R24
  article-title: Fungal secondary metabolism – from biochemistry to genomics
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1286
– volume: 61
  start-page: 1097
  year: 1992
  ident: R26
  article-title: Pheromone response in yeast
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.bi.61.070192.005313
– volume: 154
  start-page: 392
  year: 2008
  ident: R47
  article-title: Functional analyses of heterotrimeric G protein G α and G β subunits in Gibberella zeae
  publication-title: Microbiology
  doi: 10.1099/mic.0.2007/012260-0
– volume: 46
  start-page: 461
  year: 1992
  ident: R1
  article-title: Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation and evolution
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev.mi.46.100192.002333
– volume: 145
  start-page: 317
  year: 1999
  ident: R19
  article-title: Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs
  publication-title: Microbiology
  doi: 10.1099/13500872-145-2-317
– volume: 43
  start-page: 618
  year: 2006
  ident: R14
  article-title: Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum
  publication-title: Fungal Genet Biol
  doi: 10.1016/j.fgb.2006.03.001
– volume: 22
  start-page: 931
  year: 2000
  ident: R2
  article-title: Enhancement of chrysogenin production in cultures of Penicillium chrysogenum by uronic acid oligosaccharides
  publication-title: Biotechnol Lett
  doi: 10.1023/A:1005694415666
– volume: 66
  start-page: 447
  year: 2002
  ident: R6
  article-title: Relationship between secondary metabolism and fungal development
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.66.3.447-459.2002
– volume: 25
  start-page: 143
  year: 1998
  ident: R4
  article-title: Sex and crime: heterotrimeric G proteins in fungal mating and pathogenesis
  publication-title: Fungal Genet Biol
  doi: 10.1006/fgbi.1998.1102
– volume: 1002
  start-page: 111
  year: 2003
  ident: R35
  article-title: Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology
  publication-title: J Chromatogr A
  doi: 10.1016/S0021-9673(03)00490-4
– volume: 15
  start-page: 5184
  year: 1996
  ident: R46
  article-title: The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1996.tb00903.x
– volume: 181
  start-page: 1181
  year: 1999
  ident: R7
  article-title: Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction
  publication-title: J Bacteriol
  doi: 10.1128/JB.181.4.1181-1188.1999
– volume: 42
  start-page: 749
  year: 2005
  ident: R37
  article-title: The G protein α subunit Tga1 of Trichoderma atroviride is involved in chitinase formation and differential production of antifungal metabolites
  publication-title: Fungal Genet Biol
  doi: 10.1016/j.fgb.2005.04.009
– volume: 38
  start-page: 658
  year: 2000
  ident: R42
  article-title: G-protein signalling mediates differential production of toxic secondary metabolites
  publication-title: Mol Microbiol
  doi: 10.1046/j.1365-2958.2000.02166.x
– volume: 167
  start-page: 1305
  year: 2004
  ident: R8
  article-title: The GanB G α-protein negatively regulates asexual sporulation and plays a positive role in conidial germination in Aspergillus nidulans
  publication-title: Genetics
  doi: 10.1534/genetics.103.025379
– volume: 61
  start-page: 385
  year: 2003
  ident: R10
  article-title: Industrial production of beta-lactam antibiotics
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/s00253-003-1274-y
– volume: 24
  start-page: 393
  year: 2007
  ident: R22
  article-title: Natural products of filamentous fungi: enzymes, genes, and their regulation
  publication-title: Nat Prod Rep
  doi: 10.1039/B603084J
– volume: 86
  start-page: 57
  year: 2008
  ident: R18
  article-title: Heterotrimeric G α protein Pga1 of Penicillium chrysogenum controls conidiation mainly by a cAMP-independent mechanism
  publication-title: Biochem Cell Biol
  doi: 10.1139/O07-148
– volume: 92
  start-page: 6200
  year: 1995
  ident: R11
  article-title: The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.13.6200
– volume: 275
  start-page: 2423
  year: 2000
  ident: R25
  article-title: A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.4.2423
– volume: 80
  start-page: 249
  year: 1995
  ident: R34
  article-title: Heterotrimeric G proteins: organizers of transmembrane signals
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90407-7
– volume: 20
  start-page: 529
  year: 1996
  ident: R41
  article-title: Characterisation of a Penicillium chrysogenum gene encoding a PacC transcription factor and its binding sites in the divergent pcbAB-pcbC promoter of the penicillin biosynthetic cluster
  publication-title: Mol Microbiol
  doi: 10.1046/j.1365-2958.1996.5421065.x
– volume: 438
  start-page: 1151
  year: 2005
  ident: R36
  article-title: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
  publication-title: Nature
  doi: 10.1038/nature04332
– volume: 15
  start-page: 591
  year: 2001
  ident: R40
  article-title: Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
  publication-title: Genetics
  doi: 10.1093/genetics/157.2.591
– volume: 62
  start-page: 547
  year: 1998
  ident: R5
  article-title: Molecular regulation of beta-lactam biosynthesis in filamentous fungi
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.62.3.547-585.1998
– volume: 182
  start-page: 2355
  year: 2000
  ident: R32
  article-title: Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region
  publication-title: J Bacteriol
  doi: 10.1128/JB.182.9.2355-2362.2000
– volume: 1
  start-page: 440
  year: 2002
  ident: R49
  article-title: G-protein signaling mediates asexual development at 25 °C but has no effect on yeast-like growth at 37 °C in the dimorphic fungus Penicillium marneffei
  publication-title: Eukaryot Cell
  doi: 10.1128/EC.1.3.440-447.2002
– volume: 90
  start-page: 181
  year: 2004
  ident: R38
  article-title: The presence of Penicillium and Penicillium mycotoxins in food wastes
  publication-title: Int J Food Microbiol
  doi: 10.1016/S0168-1605(03)00291-5
– volume: 44
  start-page: 830
  year: 2007
  ident: R43
  article-title: Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255
  publication-title: Fungal Genet Biol
  doi: 10.1016/j.fgb.2007.03.008
– volume: 158
  start-page: 437
  year: 2007
  ident: R17
  article-title: The pga1 gene of Penicillium chrysogenum encodes a heterotrimeric G protein alpha subunit that controls growth and development
  publication-title: Res Microbiol
  doi: 10.1016/j.resmic.2007.03.001
– volume: 163
  start-page: 161
  year: 2007
  ident: R9
  article-title: Toxins from strains of Penicillium chrysogenum isolated from buildings and other sources
  publication-title: Mycopathologia
  doi: 10.1007/s11046-007-0091-8
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StartPage 3567
SubjectTerms Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene expression
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
Molecular and cellular biology
Molecular genetics
Mycology
Title The heterotrimeric Gα protein Pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum
Volume 154
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