The Absolute Number of Extranodal Sites Detected By PET-CT Is a Powerful Predictor of Secondary Central Nervous System Involvement in Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP

• Published in: Blood Vol. 126; no. 23; p. 3905
• Main Authors: Cheah, Chan Yoon, Hutchings, Martin, Rady, Kirsty, Savage, Kerry J., Alzahrani, Musa F., Sehn, Laurie H., Barrington, Sally, Mikhaeel, George, Kansara, Roopesh R., Hansen, Jakob Werner, Smith, Daniel, Mylam, Karen Juul, Larsen, Thomas Stauffer, Holmberg, Staffan, Juul, Maja, Cordua, Sabrina, Clausen, Michael Roost, Jensen, Kkristina Buchardi, Bogsted, Martin, Johnsen, Hans Erik, Connors, Joseph M., Brown, Peter de Nully, Seymour, John F., Villa, Diego, El-Galaly, Tarec Christoffer
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Background Central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma (DLBCL) is an infrequent but devastating complication. The German Risk model which includes the 5 IPI risk factors plus involvement of the kidneys has been validated in 2 large independent cohorts (Schmitz...