Stem cells in orthopaedics and sports injuries: A comprehensive review and future research directions

With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the body's natural ability to heal, stem cell treatment provides a regenerative method for repairing and regenerating damaged tissues. The fun...

Full description

Saved in:
Bibliographic Details
Published inJournal of Orthopaedic Reports Vol. 3; no. 4; p. 100344
Main Authors Vaish, Abhishek, Vaishya, Raju
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2024
Elsevier
Subjects
Online AccessGet full text

Cover

Loading…
Abstract With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the body's natural ability to heal, stem cell treatment provides a regenerative method for repairing and regenerating damaged tissues. The function of stem cells in orthopaedics and sports injuries is thoroughly reviewed in this review paper, which also discusses future possibilities for clinical research and practice as well as possible applications and mechanisms of action. The literature was searched using the keywords “Stem Cells” AND “Orthopedics” OR “Orthopaedics” OR “Sports Medicine” in the databases of PubMed, Scopus, and Google Scholar. This review included the pertinent literature was included in this review. We have summarised the up-to-date knowledge about various aspects of stem cells in Orthopaedics and Sports injuries viz. stem cell types, mechanism of action, clinical applications, recent advances, research, ethical aspects and future directions. We have identified the potential research areas and research gaps in stem cell science related to musculoskeletal problems. Stem cell therapy represents a paradigm shift in orthopaedic medicine, offering regenerative solutions for a range of musculoskeletal conditions and sports injuries. From regenerating damaged tissues to enhancing athletic performance and recovery, stem cell therapy offers novel solutions to age-old challenges. The integration of stem cell technologies into orthopaedic practice holds promise for improving patient outcomes, reducing healthcare costs, and addressing unmet clinical needs in the management of musculoskeletal disorders.
AbstractList Background and aims: With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the body's natural ability to heal, stem cell treatment provides a regenerative method for repairing and regenerating damaged tissues. The function of stem cells in orthopaedics and sports injuries is thoroughly reviewed in this review paper, which also discusses future possibilities for clinical research and practice as well as possible applications and mechanisms of action. Methods: The literature was searched using the keywords “Stem Cells” AND “Orthopedics” OR “Orthopaedics” OR “Sports Medicine” in the databases of PubMed, Scopus, and Google Scholar. This review included the pertinent literature was included in this review. Results: We have summarised the up-to-date knowledge about various aspects of stem cells in Orthopaedics and Sports injuries viz. stem cell types, mechanism of action, clinical applications, recent advances, research, ethical aspects and future directions. We have identified the potential research areas and research gaps in stem cell science related to musculoskeletal problems. Conclusion: Stem cell therapy represents a paradigm shift in orthopaedic medicine, offering regenerative solutions for a range of musculoskeletal conditions and sports injuries. From regenerating damaged tissues to enhancing athletic performance and recovery, stem cell therapy offers novel solutions to age-old challenges. The integration of stem cell technologies into orthopaedic practice holds promise for improving patient outcomes, reducing healthcare costs, and addressing unmet clinical needs in the management of musculoskeletal disorders.
With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the body's natural ability to heal, stem cell treatment provides a regenerative method for repairing and regenerating damaged tissues. The function of stem cells in orthopaedics and sports injuries is thoroughly reviewed in this review paper, which also discusses future possibilities for clinical research and practice as well as possible applications and mechanisms of action. The literature was searched using the keywords “Stem Cells” AND “Orthopedics” OR “Orthopaedics” OR “Sports Medicine” in the databases of PubMed, Scopus, and Google Scholar. This review included the pertinent literature was included in this review. We have summarised the up-to-date knowledge about various aspects of stem cells in Orthopaedics and Sports injuries viz. stem cell types, mechanism of action, clinical applications, recent advances, research, ethical aspects and future directions. We have identified the potential research areas and research gaps in stem cell science related to musculoskeletal problems. Stem cell therapy represents a paradigm shift in orthopaedic medicine, offering regenerative solutions for a range of musculoskeletal conditions and sports injuries. From regenerating damaged tissues to enhancing athletic performance and recovery, stem cell therapy offers novel solutions to age-old challenges. The integration of stem cell technologies into orthopaedic practice holds promise for improving patient outcomes, reducing healthcare costs, and addressing unmet clinical needs in the management of musculoskeletal disorders.
ArticleNumber 100344
Author Vaish, Abhishek
Vaishya, Raju
Author_xml – sequence: 1
  givenname: Abhishek
  orcidid: 0000-0001-7347-0917
  surname: Vaish
  fullname: Vaish, Abhishek
  email: drabhishekvaish@gmail.com
– sequence: 2
  givenname: Raju
  orcidid: 0000-0002-9577-9533
  surname: Vaishya
  fullname: Vaishya, Raju
  email: raju.vaishya@gmail.com
BookMark eNp9kN9KwzAUxoNMcM49gTd5gc4kTZdW8GIM_wwGXqjgXUiTE5fSNSXpJr697SrilVfn8J3zfZzzu0STxjeA0DUlC0ro8qZaVD5Au2CE8V4hKednaMqESBOaiffJn_4CzWOsCCEsz5YFyacIXjrYYw11HbFrsA_dzrcKjNMRq8bg2PbSMKoOwUG8xSus_b4NsIMmuiPgAEcHn6dde-gOYVAiqKB32LgAunO-iVfo3Ko6wvynztDbw_3r-inZPj9u1qttohkpeGIKCxR4qWxBCdeW2lQLLpSlQBQXhjORK8EhA8IUV7oUnFgL_TJlIHiZztBmzDVeVbINbq_Cl_TKyZPgw4dUoXO6BmlzURqbpYpqzksgBStzbbWhHOzSlHmflY5ZOvgYA9jfPErkAF5W8gReDuDlCL533Y0u6N_syQQZtYNGwwijv8P96_8GjQSRrQ
Cites_doi 10.32607/20758251-2010-2-2-18-27
10.1002/bdrc.21041
10.1016/j.lfs.2017.04.014
10.1007/s11684-021-0900-3
10.1016/j.omtm.2019.10.010
10.3390/ijms24076405
10.1002/cyto.a.23242
10.1002/jor.24261
10.1016/j.biomaterials.2018.07.017
10.3390/cells10081959
10.1186/scrt98
10.2147/OAJSM.S72332
10.1177/2192568220948479
10.3727/096368912X656171
10.1097/NOR.0000000000000502
10.1007/7651_2021_408
10.3390/ijms23137306
10.1016/j.jtha.2023.06.014
10.25259/JASSM_12_2020
10.5812/atr.37976
10.1186/s13287-018-0791-7
10.1038/s41598-020-76466-8
10.1016/j.stem.2022.10.001
10.1002/jor.24136
10.1016/j.jconrel.2019.02.038
10.1080/14712598.2022.2016695
10.3390/ijms21113994
10.1002/stem.776
10.1097/SAP.0000000000001763
10.1016/j.msec.2020.110788
10.1016/j.jcot.2018.12.007
10.1038/s41392-022-01134-4
10.1371/journal.pone.0251166
10.1016/j.scr.2013.05.001
10.3727/096368910X
10.1016/j.biotechadv.2018.03.011
10.2217/epi-2020-0409
10.1007/s00264-020-04926-x
10.1007/s12178-020-09647-7
10.1186/s13287-021-02360-3
10.1146/annurev.cellbio.042308.113248
ContentType Journal Article
Copyright 2024 The Authors
Copyright_xml – notice: 2024 The Authors
DBID 6I.
AAFTH
AAYXX
CITATION
DOA
DOI 10.1016/j.jorep.2024.100344
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList

Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2773-157X
ExternalDocumentID oai_doaj_org_article_f87bdf53a1c44be092b8cfcd14ef6db8
10_1016_j_jorep_2024_100344
S2773157X24000390
GroupedDBID .1-
.FO
0SF
6I.
AAFTH
AAXUO
AEXQZ
AFCTW
AFRHN
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
EBS
FDB
GROUPED_DOAJ
M41
M~E
ROL
Z5R
AALRI
AAYXX
ADVLN
AFJKZ
AITUG
CITATION
ID FETCH-LOGICAL-c2094-d9fe1e4baf9104cf1f3c747af1e0a47d4278a74e5e02a4acb740ffe91012e74b3
IEDL.DBID DOA
ISSN 2773-157X
IngestDate Tue Oct 22 15:05:54 EDT 2024
Thu Nov 21 23:20:16 EST 2024
Sat Apr 27 15:44:28 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Knee
Regeneration
Joint
Orthopedics
Stem cells
Sports medicine
Language English
License This is an open access article under the CC BY-NC-ND license.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c2094-d9fe1e4baf9104cf1f3c747af1e0a47d4278a74e5e02a4acb740ffe91012e74b3
ORCID 0000-0001-7347-0917
0000-0002-9577-9533
OpenAccessLink https://doaj.org/article/f87bdf53a1c44be092b8cfcd14ef6db8
ParticipantIDs doaj_primary_oai_doaj_org_article_f87bdf53a1c44be092b8cfcd14ef6db8
crossref_primary_10_1016_j_jorep_2024_100344
elsevier_sciencedirect_doi_10_1016_j_jorep_2024_100344
PublicationCentury 2000
PublicationDate December 2024
2024-12-00
2024-12-01
PublicationDateYYYYMMDD 2024-12-01
PublicationDate_xml – month: 12
  year: 2024
  text: December 2024
PublicationDecade 2020
PublicationTitle Journal of Orthopaedic Reports
PublicationYear 2024
Publisher Elsevier B.V
Elsevier
Publisher_xml – name: Elsevier B.V
– name: Elsevier
References Bacakova, Zarubova, Travnickova (bib13) 2018; 36
Rackwitz, Eden, Reppenhagen (bib21) 2012; 3
Pappalardo, Montesano, Toia (bib17) 2019; 82
Yamazaki, Kawabori, Seki, Houkin (bib40) 2020; 21
Wang, Fang, Liu, Shao, Shi (bib41) 2022; 29
Kasai, Tohyama, Suzuki (bib42) 2020; 111
Barlian, Judawisastra, Ridwan, Wahyuni, Lingga (bib34) 2020; 10
Blandinières, Randi, Paschalaki, Guerin, Melero-Martin, Smadja (bib38) 2023; 21
Lolli, Colella, De Bari, van Osch (bib2) 2019; 37
Pawar, Vaish, Vaishya (bib22) 2021 Nov 11; 24
Lv, Wang, Zhang (bib44) 2017; 178
Hade, Suire, Suo (bib28) 2021; 10
Fan, Liu, Zhang, Chen, Yang, Yu (bib30) 2021 May 29; 12
Yang, Rothrauff, Tuan (bib24) 2013; 99
Shanmugasundaram, Vaish, Chavada, Murrell, Vaishya (bib11) 2021 Mar; 45
Peytour, Villacreces, Chevaleyre, Ivanovic, Praloran (bib39) 2013; 11
Veneruso, Rossi, Villella, Bena, Forloni, Veglianese (bib7) 2019; 300
Ajibade, Vance, Hare, Kaplan, Lesniak (bib4) 2014; 2
González-Martínez, Malumbres (bib15) 2022; 2454
Zhou, Guo, Sun, Ren, Tao (bib35) 2023; 2023
Bhujel, Shin, Choi, Han (bib37) 2022; 23
Oh, Humphries (bib3) 2012; 30
Liu, Pei, Li, Zhang (bib18) 2022; 16
Piuzzi, Emara, Chahla, Mandelbaum (bib32) 2020; 13
Giorgino, Albano, Fusco, Peretti, Mangiavini, Messina (bib20) 2023; 24
Moisley, El-Jawhari, Owston (bib29) 2019; 37
Keshtkar, Azarpira, Ghahremani (bib16) 2018; 9
Maali, Maroufi, Sadeghi (bib12) 2021; 13
Akpancar, Tatar, Turgut, Akyildiz, Ekinci (bib19) 2016 Aug 16; 5
Hoang, Pham, Bach (bib26) 2022 Aug 6; 7
Vaish, Murrell, Vaishya (bib8) 2020; 1
Medvedev, Shevchenko, Zakian (bib10) 2010 Jul; 2
Drysdale, Tisdale, Uchida (bib27) 2019; 16
Lu, Xie, Zhao, Chen (bib31) 2013; 22
Zhang, Li, Augi (bib36) 2021; 16
Mushahary, Spittler, Kasper, Weber, Charwat (bib33) 2018; 93
Nyland, Mattocks, Kibbe, Kalloub, Greene, Caborn (bib6) 2016; 7
Ho-Shui-Ling, Bolander, Rustom, Johnson, Luyten, Picart (bib23) 2018; 180
Ding, Shyu, Lin (bib9) 2011; 20
Hsieh, Chung, Brodke (bib25) 2021; 11
Chahla, Alland, Verma (bib5) 2018; 37
Bagno, Salerno, Balkan, Hare (bib14) 2022 Apr; 22
Vaishya (bib1) 2019 Jan-Feb; 10
He, Nakada, Morrison (bib43) 2009; 25
Peytour (10.1016/j.jorep.2024.100344_bib39) 2013; 11
Kasai (10.1016/j.jorep.2024.100344_bib42) 2020; 111
Barlian (10.1016/j.jorep.2024.100344_bib34) 2020; 10
Lolli (10.1016/j.jorep.2024.100344_bib2) 2019; 37
Liu (10.1016/j.jorep.2024.100344_bib18) 2022; 16
Yamazaki (10.1016/j.jorep.2024.100344_bib40) 2020; 21
Giorgino (10.1016/j.jorep.2024.100344_bib20) 2023; 24
Hsieh (10.1016/j.jorep.2024.100344_bib25) 2021; 11
Zhou (10.1016/j.jorep.2024.100344_bib35) 2023; 2023
He (10.1016/j.jorep.2024.100344_bib43) 2009; 25
Blandinières (10.1016/j.jorep.2024.100344_bib38) 2023; 21
Nyland (10.1016/j.jorep.2024.100344_bib6) 2016; 7
Lv (10.1016/j.jorep.2024.100344_bib44) 2017; 178
Bhujel (10.1016/j.jorep.2024.100344_bib37) 2022; 23
Shanmugasundaram (10.1016/j.jorep.2024.100344_bib11) 2021; 45
Fan (10.1016/j.jorep.2024.100344_bib30) 2021; 12
Moisley (10.1016/j.jorep.2024.100344_bib29) 2019; 37
Yang (10.1016/j.jorep.2024.100344_bib24) 2013; 99
Zhang (10.1016/j.jorep.2024.100344_bib36) 2021; 16
Keshtkar (10.1016/j.jorep.2024.100344_bib16) 2018; 9
Rackwitz (10.1016/j.jorep.2024.100344_bib21) 2012; 3
Ho-Shui-Ling (10.1016/j.jorep.2024.100344_bib23) 2018; 180
Hoang (10.1016/j.jorep.2024.100344_bib26) 2022; 7
González-Martínez (10.1016/j.jorep.2024.100344_bib15) 2022; 2454
Pawar (10.1016/j.jorep.2024.100344_bib22) 2021; 24
Piuzzi (10.1016/j.jorep.2024.100344_bib32) 2020; 13
Vaishya (10.1016/j.jorep.2024.100344_bib1) 2019; 10
Maali (10.1016/j.jorep.2024.100344_bib12) 2021; 13
Ajibade (10.1016/j.jorep.2024.100344_bib4) 2014; 2
Chahla (10.1016/j.jorep.2024.100344_bib5) 2018; 37
Ding (10.1016/j.jorep.2024.100344_bib9) 2011; 20
Vaish (10.1016/j.jorep.2024.100344_bib8) 2020; 1
Oh (10.1016/j.jorep.2024.100344_bib3) 2012; 30
Wang (10.1016/j.jorep.2024.100344_bib41) 2022; 29
Veneruso (10.1016/j.jorep.2024.100344_bib7) 2019; 300
Medvedev (10.1016/j.jorep.2024.100344_bib10) 2010; 2
Bagno (10.1016/j.jorep.2024.100344_bib14) 2022; 22
Lu (10.1016/j.jorep.2024.100344_bib31) 2013; 22
Pappalardo (10.1016/j.jorep.2024.100344_bib17) 2019; 82
Mushahary (10.1016/j.jorep.2024.100344_bib33) 2018; 93
Akpancar (10.1016/j.jorep.2024.100344_bib19) 2016; 5
Hade (10.1016/j.jorep.2024.100344_bib28) 2021; 10
Bacakova (10.1016/j.jorep.2024.100344_bib13) 2018; 36
Drysdale (10.1016/j.jorep.2024.100344_bib27) 2019; 16
References_xml – volume: 2023
  year: 2023
  ident: bib35
  article-title: Extracellular vesicles secreted by TGF-
  publication-title: Stem Cell Int
  contributor:
    fullname: Tao
– volume: 9
  start-page: 63
  year: 2018
  ident: bib16
  article-title: Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
  publication-title: Stem Cell Res Ther
  contributor:
    fullname: Ghahremani
– volume: 13
  start-page: 631
  year: 2021
  end-page: 647
  ident: bib12
  article-title: Induced pluripotent stem cell technology: trends in molecular biology, from genetics to epigenetics
  publication-title: Epigenomics
  contributor:
    fullname: Sadeghi
– volume: 82
  start-page: 245
  year: 2019
  end-page: 251
  ident: bib17
  article-title: Immunomodulation in vascularized composite allotransplantation: what is the role for adipose-derived stem cells?
  publication-title: Ann Plast Surg
  contributor:
    fullname: Toia
– volume: 16
  start-page: 56
  year: 2022
  end-page: 82
  ident: bib18
  article-title: Decellularized extracellular matrix mediates tissue construction and regeneration
  publication-title: Front Med
  contributor:
    fullname: Zhang
– volume: 24
  start-page: 6405
  year: 2023
  ident: bib20
  article-title: Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update
  publication-title: Int J Mol Sci
  contributor:
    fullname: Messina
– volume: 25
  start-page: 377
  year: 2009
  end-page: 406
  ident: bib43
  article-title: Mechanisms of stem cell self-renewal
  publication-title: Annu Rev Cell Dev Biol
  contributor:
    fullname: Morrison
– volume: 2
  year: 2014
  ident: bib4
  article-title: Emerging applications of stem cell and regenerative medicine to sports injuries
  publication-title: Orthop J Sports Med
  contributor:
    fullname: Lesniak
– volume: 10
  start-page: 1959
  year: 2021
  ident: bib28
  article-title: Mesenchymal stem cell-derived exosomes: applications in regenerative medicine
  publication-title: Cells
  contributor:
    fullname: Suo
– volume: 29
  start-page: 1515
  year: 2022
  end-page: 1530
  ident: bib41
  article-title: Reciprocal regulation of mesenchymal stem cells and immune responses
  publication-title: Cell Stem Cell
  contributor:
    fullname: Shi
– volume: 16
  start-page: 42
  year: 2019
  end-page: 49
  ident: bib27
  article-title: Immunoresponse to gene-modified hematopoietic stem cells
  publication-title: Mol Ther Methods Clin Dev
  contributor:
    fullname: Uchida
– volume: 11
  start-page: 950
  year: 2021
  end-page: 965
  ident: bib25
  article-title: Autologous stem cells in cervical spine fusion
  publication-title: Global Spine J
  contributor:
    fullname: Brodke
– volume: 23
  start-page: 7306
  year: 2022
  ident: bib37
  article-title: Mesenchymal stem cell-derived exosomes and intervertebral disc regeneration: review
  publication-title: Int J Mol Sci
  contributor:
    fullname: Han
– volume: 30
  start-page: 82
  year: 2012
  end-page: 88
  ident: bib3
  article-title: Concise review: multidimensional regulation of the hematopoietic stem cell state
  publication-title: Stem Cell
  contributor:
    fullname: Humphries
– volume: 22
  start-page: 205
  year: 2013
  end-page: 229
  ident: bib31
  article-title: Translational research and therapeutic applications of stem cell transplantation in periodontal regenerative medicine
  publication-title: Cell Transplant
  contributor:
    fullname: Chen
– volume: 37
  start-page: 12
  year: 2019
  end-page: 22
  ident: bib2
  article-title: Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: a new paradigm in cartilage repair
  publication-title: J Orthop Res
  contributor:
    fullname: van Osch
– volume: 37
  start-page: 1329
  year: 2019
  end-page: 1338
  ident: bib29
  article-title: Optimising proliferation and migration of mesenchymal stem cells using platelet products: a rational approach to bone regeneration [published correction appears in J Orthop Res. 2019 Sep;37(9):2061]
  publication-title: J Orthop Res
  contributor:
    fullname: Owston
– volume: 178
  start-page: 42
  year: 2017
  end-page: 48
  ident: bib44
  article-title: Biomaterial stiffness determines stem cell fate
  publication-title: Life Sci
  contributor:
    fullname: Zhang
– volume: 300
  start-page: 141
  year: 2019
  end-page: 153
  ident: bib7
  article-title: Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration
  publication-title: J Contr Release
  contributor:
    fullname: Veglianese
– volume: 22
  start-page: 449
  year: 2022 Apr
  end-page: 463
  ident: bib14
  article-title: Mechanism of action of mesenchymal stem cells (MSCs): impact of delivery method
  publication-title: Expet Opin Biol Ther
  contributor:
    fullname: Hare
– volume: 20
  start-page: 5
  year: 2011
  end-page: 14
  ident: bib9
  article-title: Mesenchymal stem cells
  publication-title: Cell Transplant
  contributor:
    fullname: Lin
– volume: 36
  start-page: 1111
  year: 2018
  end-page: 1126
  ident: bib13
  article-title: Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review
  publication-title: Biotechnol Adv
  contributor:
    fullname: Travnickova
– volume: 5
  year: 2016 Aug 16
  ident: bib19
  article-title: The current perspectives of stem cell therapy in orthopedic surgery
  publication-title: Arch Trauma Res
  contributor:
    fullname: Ekinci
– volume: 21
  start-page: 3994
  year: 2020
  ident: bib40
  article-title: Clinical trials of stem cell treatment for spinal cord injury
  publication-title: Int J Mol Sci
  contributor:
    fullname: Houkin
– volume: 10
  year: 2020
  ident: bib34
  article-title: Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich plasma
  publication-title: Sci Rep
  contributor:
    fullname: Lingga
– volume: 11
  start-page: 736
  year: 2013
  end-page: 742
  ident: bib39
  article-title: Discarded leukoreduction filters: a new source of stem cells for research, cell engineering and therapy?
  publication-title: Stem Cell Res
  contributor:
    fullname: Praloran
– volume: 24
  year: 2021 Nov 11
  ident: bib22
  article-title: Core decompression and bone marrow aspirate concentrate injection for Avascular Necrosis (AVN) of the femoral head: a scoping review
  publication-title: J Clin Orthop Trauma
  contributor:
    fullname: Vaishya
– volume: 3
  start-page: 7
  year: 2012
  ident: bib21
  article-title: Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head
  publication-title: Stem Cell Res Ther
  contributor:
    fullname: Reppenhagen
– volume: 21
  start-page: 2611
  year: 2023
  end-page: 2619
  ident: bib38
  article-title: Results of an international survey about methods used to isolate human endothelial colony-forming cells: guidance from the SSC on Vascular Biology of the ISTH
  publication-title: J Thromb Haemostasis
  contributor:
    fullname: Smadja
– volume: 37
  start-page: 379
  year: 2018
  end-page: 381
  ident: bib5
  article-title: Bone marrow aspirate concentrate for orthopaedic use
  publication-title: Orthop Nurs
  contributor:
    fullname: Verma
– volume: 2454
  start-page: 95
  year: 2022
  end-page: 107
  ident: bib15
  article-title: Expanding the differentiation potential of already-established pluripotent stem cells
  publication-title: Methods Mol Biol
  contributor:
    fullname: Malumbres
– volume: 111
  year: 2020
  ident: bib42
  article-title: Cost-effective culture of human induced pluripotent stem cells using UV/ozone-modified culture plastics with reduction of cell-adhesive matrix coating
  publication-title: Mater Sci Eng C
  contributor:
    fullname: Suzuki
– volume: 10
  start-page: 1
  year: 2019 Jan-Feb
  ident: bib1
  article-title: Regeneration is better than the replacement
  publication-title: J Clin Orthop Trauma
  contributor:
    fullname: Vaishya
– volume: 16
  year: 2021
  ident: bib36
  article-title: Platelet HMGB1 in Platelet-Rich Plasma (PRP) promotes tendon wound healing
  publication-title: PLoS One
  contributor:
    fullname: Augi
– volume: 45
  start-page: 615
  year: 2021 Mar
  end-page: 625
  ident: bib11
  article-title: Assessment of safety and efficacy of intra-articular injection of stromal vascular fraction for the treatment of knee osteoarthritis-a systematic review
  publication-title: Int Orthop
  contributor:
    fullname: Vaishya
– volume: 99
  start-page: 203
  year: 2013
  end-page: 222
  ident: bib24
  article-title: Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm
  publication-title: Birth Defects Res C Embryo Today
  contributor:
    fullname: Tuan
– volume: 7
  start-page: 272
  year: 2022 Aug 6
  ident: bib26
  article-title: Stem cell-based therapy for human diseases
  publication-title: Signal Transduct Targeted Ther
  contributor:
    fullname: Bach
– volume: 1
  start-page: 154
  year: 2020
  end-page: 158
  ident: bib8
  article-title: History of regenerative medicine in the field of orthopedics
  publication-title: J Arthrosc Surg Sport Med
  contributor:
    fullname: Vaishya
– volume: 12
  start-page: 307
  year: 2021 May 29
  ident: bib30
  article-title: Principles for establishment of the stem cell bank and its applications on management of sports injuries
  publication-title: Stem Cell Res Ther
  contributor:
    fullname: Yu
– volume: 180
  start-page: 143
  year: 2018
  end-page: 162
  ident: bib23
  article-title: Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives
  publication-title: Biomaterials
  contributor:
    fullname: Picart
– volume: 13
  start-page: 525
  year: 2020
  end-page: 529
  ident: bib32
  article-title: Ethical and practical considerations for integrating cellular ("Stem cell") therapy into clinical practice
  publication-title: Curr Rev Musculoskelet Med
  contributor:
    fullname: Mandelbaum
– volume: 7
  start-page: 21
  year: 2016
  end-page: 32
  ident: bib6
  article-title: Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update
  publication-title: Open Access J Sports Med
  contributor:
    fullname: Caborn
– volume: 2
  start-page: 18
  year: 2010 Jul
  end-page: 28
  ident: bib10
  article-title: Induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine
  publication-title: Acta Naturae
  contributor:
    fullname: Zakian
– volume: 93
  start-page: 19
  year: 2018
  end-page: 31
  ident: bib33
  article-title: Isolation, cultivation, and characterization of human mesenchymal stem cells
  publication-title: Cytometry
  contributor:
    fullname: Charwat
– volume: 2
  start-page: 18
  issue: 2
  year: 2010
  ident: 10.1016/j.jorep.2024.100344_bib10
  article-title: Induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine
  publication-title: Acta Naturae
  doi: 10.32607/20758251-2010-2-2-18-27
  contributor:
    fullname: Medvedev
– volume: 99
  start-page: 203
  issue: 3
  year: 2013
  ident: 10.1016/j.jorep.2024.100344_bib24
  article-title: Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm
  publication-title: Birth Defects Res C Embryo Today
  doi: 10.1002/bdrc.21041
  contributor:
    fullname: Yang
– volume: 178
  start-page: 42
  year: 2017
  ident: 10.1016/j.jorep.2024.100344_bib44
  article-title: Biomaterial stiffness determines stem cell fate
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2017.04.014
  contributor:
    fullname: Lv
– volume: 16
  start-page: 56
  issue: 1
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib18
  article-title: Decellularized extracellular matrix mediates tissue construction and regeneration
  publication-title: Front Med
  doi: 10.1007/s11684-021-0900-3
  contributor:
    fullname: Liu
– volume: 16
  start-page: 42
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib27
  article-title: Immunoresponse to gene-modified hematopoietic stem cells
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2019.10.010
  contributor:
    fullname: Drysdale
– volume: 24
  start-page: 6405
  issue: 7
  year: 2023
  ident: 10.1016/j.jorep.2024.100344_bib20
  article-title: Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms24076405
  contributor:
    fullname: Giorgino
– volume: 93
  start-page: 19
  issue: 1
  year: 2018
  ident: 10.1016/j.jorep.2024.100344_bib33
  article-title: Isolation, cultivation, and characterization of human mesenchymal stem cells
  publication-title: Cytometry
  doi: 10.1002/cyto.a.23242
  contributor:
    fullname: Mushahary
– volume: 37
  start-page: 1329
  issue: 6
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib29
  article-title: Optimising proliferation and migration of mesenchymal stem cells using platelet products: a rational approach to bone regeneration [published correction appears in J Orthop Res. 2019 Sep;37(9):2061]
  publication-title: J Orthop Res
  doi: 10.1002/jor.24261
  contributor:
    fullname: Moisley
– volume: 180
  start-page: 143
  year: 2018
  ident: 10.1016/j.jorep.2024.100344_bib23
  article-title: Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.07.017
  contributor:
    fullname: Ho-Shui-Ling
– volume: 10
  start-page: 1959
  issue: 8
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib28
  article-title: Mesenchymal stem cell-derived exosomes: applications in regenerative medicine
  publication-title: Cells
  doi: 10.3390/cells10081959
  contributor:
    fullname: Hade
– volume: 3
  start-page: 7
  issue: 1
  year: 2012
  ident: 10.1016/j.jorep.2024.100344_bib21
  article-title: Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt98
  contributor:
    fullname: Rackwitz
– volume: 7
  start-page: 21
  year: 2016
  ident: 10.1016/j.jorep.2024.100344_bib6
  article-title: Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update
  publication-title: Open Access J Sports Med
  doi: 10.2147/OAJSM.S72332
  contributor:
    fullname: Nyland
– volume: 11
  start-page: 950
  issue: 6
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib25
  article-title: Autologous stem cells in cervical spine fusion
  publication-title: Global Spine J
  doi: 10.1177/2192568220948479
  contributor:
    fullname: Hsieh
– volume: 22
  start-page: 205
  issue: 2
  year: 2013
  ident: 10.1016/j.jorep.2024.100344_bib31
  article-title: Translational research and therapeutic applications of stem cell transplantation in periodontal regenerative medicine
  publication-title: Cell Transplant
  doi: 10.3727/096368912X656171
  contributor:
    fullname: Lu
– volume: 37
  start-page: 379
  issue: 6
  year: 2018
  ident: 10.1016/j.jorep.2024.100344_bib5
  article-title: Bone marrow aspirate concentrate for orthopaedic use
  publication-title: Orthop Nurs
  doi: 10.1097/NOR.0000000000000502
  contributor:
    fullname: Chahla
– volume: 2454
  start-page: 95
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib15
  article-title: Expanding the differentiation potential of already-established pluripotent stem cells
  publication-title: Methods Mol Biol
  doi: 10.1007/7651_2021_408
  contributor:
    fullname: González-Martínez
– volume: 23
  start-page: 7306
  issue: 13
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib37
  article-title: Mesenchymal stem cell-derived exosomes and intervertebral disc regeneration: review
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms23137306
  contributor:
    fullname: Bhujel
– volume: 21
  start-page: 2611
  issue: 9
  year: 2023
  ident: 10.1016/j.jorep.2024.100344_bib38
  article-title: Results of an international survey about methods used to isolate human endothelial colony-forming cells: guidance from the SSC on Vascular Biology of the ISTH
  publication-title: J Thromb Haemostasis
  doi: 10.1016/j.jtha.2023.06.014
  contributor:
    fullname: Blandinières
– volume: 1
  start-page: 154
  issue: 1
  year: 2020
  ident: 10.1016/j.jorep.2024.100344_bib8
  article-title: History of regenerative medicine in the field of orthopedics
  publication-title: J Arthrosc Surg Sport Med
  doi: 10.25259/JASSM_12_2020
  contributor:
    fullname: Vaish
– volume: 5
  issue: 4
  year: 2016
  ident: 10.1016/j.jorep.2024.100344_bib19
  article-title: The current perspectives of stem cell therapy in orthopedic surgery
  publication-title: Arch Trauma Res
  doi: 10.5812/atr.37976
  contributor:
    fullname: Akpancar
– volume: 9
  start-page: 63
  issue: 1
  year: 2018
  ident: 10.1016/j.jorep.2024.100344_bib16
  article-title: Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-018-0791-7
  contributor:
    fullname: Keshtkar
– volume: 10
  issue: 1
  year: 2020
  ident: 10.1016/j.jorep.2024.100344_bib34
  article-title: Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich plasma
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-76466-8
  contributor:
    fullname: Barlian
– volume: 29
  start-page: 1515
  issue: 11
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib41
  article-title: Reciprocal regulation of mesenchymal stem cells and immune responses
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2022.10.001
  contributor:
    fullname: Wang
– volume: 37
  start-page: 12
  issue: 1
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib2
  article-title: Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: a new paradigm in cartilage repair
  publication-title: J Orthop Res
  doi: 10.1002/jor.24136
  contributor:
    fullname: Lolli
– volume: 300
  start-page: 141
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib7
  article-title: Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration
  publication-title: J Contr Release
  doi: 10.1016/j.jconrel.2019.02.038
  contributor:
    fullname: Veneruso
– volume: 22
  start-page: 449
  issue: 4
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib14
  article-title: Mechanism of action of mesenchymal stem cells (MSCs): impact of delivery method
  publication-title: Expet Opin Biol Ther
  doi: 10.1080/14712598.2022.2016695
  contributor:
    fullname: Bagno
– volume: 21
  start-page: 3994
  issue: 11
  year: 2020
  ident: 10.1016/j.jorep.2024.100344_bib40
  article-title: Clinical trials of stem cell treatment for spinal cord injury
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21113994
  contributor:
    fullname: Yamazaki
– volume: 30
  start-page: 82
  issue: 1
  year: 2012
  ident: 10.1016/j.jorep.2024.100344_bib3
  article-title: Concise review: multidimensional regulation of the hematopoietic stem cell state
  publication-title: Stem Cell
  doi: 10.1002/stem.776
  contributor:
    fullname: Oh
– volume: 82
  start-page: 245
  issue: 2
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib17
  article-title: Immunomodulation in vascularized composite allotransplantation: what is the role for adipose-derived stem cells?
  publication-title: Ann Plast Surg
  doi: 10.1097/SAP.0000000000001763
  contributor:
    fullname: Pappalardo
– volume: 24
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib22
  article-title: Core decompression and bone marrow aspirate concentrate injection for Avascular Necrosis (AVN) of the femoral head: a scoping review
  publication-title: J Clin Orthop Trauma
  contributor:
    fullname: Pawar
– volume: 111
  year: 2020
  ident: 10.1016/j.jorep.2024.100344_bib42
  article-title: Cost-effective culture of human induced pluripotent stem cells using UV/ozone-modified culture plastics with reduction of cell-adhesive matrix coating
  publication-title: Mater Sci Eng C
  doi: 10.1016/j.msec.2020.110788
  contributor:
    fullname: Kasai
– volume: 10
  start-page: 1
  issue: 1
  year: 2019
  ident: 10.1016/j.jorep.2024.100344_bib1
  article-title: Regeneration is better than the replacement
  publication-title: J Clin Orthop Trauma
  doi: 10.1016/j.jcot.2018.12.007
  contributor:
    fullname: Vaishya
– volume: 7
  start-page: 272
  issue: 1
  year: 2022
  ident: 10.1016/j.jorep.2024.100344_bib26
  article-title: Stem cell-based therapy for human diseases
  publication-title: Signal Transduct Targeted Ther
  doi: 10.1038/s41392-022-01134-4
  contributor:
    fullname: Hoang
– volume: 16
  issue: 9
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib36
  article-title: Platelet HMGB1 in Platelet-Rich Plasma (PRP) promotes tendon wound healing
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0251166
  contributor:
    fullname: Zhang
– volume: 11
  start-page: 736
  issue: 2
  year: 2013
  ident: 10.1016/j.jorep.2024.100344_bib39
  article-title: Discarded leukoreduction filters: a new source of stem cells for research, cell engineering and therapy?
  publication-title: Stem Cell Res
  doi: 10.1016/j.scr.2013.05.001
  contributor:
    fullname: Peytour
– volume: 20
  start-page: 5
  issue: 1
  year: 2011
  ident: 10.1016/j.jorep.2024.100344_bib9
  article-title: Mesenchymal stem cells
  publication-title: Cell Transplant
  doi: 10.3727/096368910X
  contributor:
    fullname: Ding
– volume: 36
  start-page: 1111
  issue: 4
  year: 2018
  ident: 10.1016/j.jorep.2024.100344_bib13
  article-title: Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review
  publication-title: Biotechnol Adv
  doi: 10.1016/j.biotechadv.2018.03.011
  contributor:
    fullname: Bacakova
– volume: 2023
  year: 2023
  ident: 10.1016/j.jorep.2024.100344_bib35
  article-title: Extracellular vesicles secreted by TGF-β1-treated mesenchymal stem cells promote fracture healing by SCD1-regulated transference of LRP5
  publication-title: Stem Cell Int
  contributor:
    fullname: Zhou
– volume: 13
  start-page: 631
  issue: 8
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib12
  article-title: Induced pluripotent stem cell technology: trends in molecular biology, from genetics to epigenetics
  publication-title: Epigenomics
  doi: 10.2217/epi-2020-0409
  contributor:
    fullname: Maali
– volume: 2
  issue: 2
  year: 2014
  ident: 10.1016/j.jorep.2024.100344_bib4
  article-title: Emerging applications of stem cell and regenerative medicine to sports injuries
  publication-title: Orthop J Sports Med
  contributor:
    fullname: Ajibade
– volume: 45
  start-page: 615
  issue: 3
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib11
  article-title: Assessment of safety and efficacy of intra-articular injection of stromal vascular fraction for the treatment of knee osteoarthritis-a systematic review
  publication-title: Int Orthop
  doi: 10.1007/s00264-020-04926-x
  contributor:
    fullname: Shanmugasundaram
– volume: 13
  start-page: 525
  issue: 4
  year: 2020
  ident: 10.1016/j.jorep.2024.100344_bib32
  article-title: Ethical and practical considerations for integrating cellular ("Stem cell") therapy into clinical practice
  publication-title: Curr Rev Musculoskelet Med
  doi: 10.1007/s12178-020-09647-7
  contributor:
    fullname: Piuzzi
– volume: 12
  start-page: 307
  issue: 1
  year: 2021
  ident: 10.1016/j.jorep.2024.100344_bib30
  article-title: Principles for establishment of the stem cell bank and its applications on management of sports injuries
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-021-02360-3
  contributor:
    fullname: Fan
– volume: 25
  start-page: 377
  year: 2009
  ident: 10.1016/j.jorep.2024.100344_bib43
  article-title: Mechanisms of stem cell self-renewal
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.042308.113248
  contributor:
    fullname: He
SSID ssj0002856908
Score 2.3265116
SecondaryResourceType review_article
Snippet With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the...
Background and aims: With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in...
SourceID doaj
crossref
elsevier
SourceType Open Website
Aggregation Database
Publisher
StartPage 100344
SubjectTerms Joint
Knee
Orthopedics
Regeneration
Sports medicine
Stem cells
Title Stem cells in orthopaedics and sports injuries: A comprehensive review and future research directions
URI https://dx.doi.org/10.1016/j.jorep.2024.100344
https://doaj.org/article/f87bdf53a1c44be092b8cfcd14ef6db8
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07T8MwELZQJxYEAkR5yQMjEYlzebEV1KpCKgtU6hb5cVYbiRS1ZeW347NTVBZYWDIklh195-Tu7M_fMXajQWJi8jzSKEwERpWRMqCiBMEgJkJU_mzV5DkfT-Fpls12Sn0RJyzIAwfg7mxZKGOzVCYaQGFcCVVqq00CaHPXtf_7xmInmWr8klHm0r5yKzPkCV3NcoWkUCmAqAEpwA9X5BX7dzzSjpcZHbKDLjzkg_BaR2wP22OGLxt847TEvuaLltNOi0t1aYdlzWVruM9M6VFD9efW93zAiSm-wnlgp_NwPsW3DRoivNP4mfPg0mjunbDpaPj6OI668giRFi4pi0xl0UGqpHUuH7RNbKpdciBtgrGEwlARDVkAZhgLCVKrAmJrsSJFLyxApaes1y5bPGMc3WdeuFDFumgGUjTSukBL5gI1eXRR9tntFqn6Pahg1Ft6WFN7YGsCtg7A9tkDofndlCSs_Q1n2LozbP2XYfss39qi7qKBAInravHb6Of_MfoF26cuA3HlkvU2qw-8cuHHRl37meauk8_hF71F3j0
link.rule.ids 314,780,784,864,2102,27924,27925
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stem+cells+in+orthopaedics+and+sports+injuries%3A+A+comprehensive+review+and+future+research+directions&rft.jtitle=Journal+of+Orthopaedic+Reports&rft.au=Abhishek+Vaish&rft.au=Raju+Vaishya&rft.date=2024-12-01&rft.pub=Elsevier&rft.eissn=2773-157X&rft.volume=3&rft.issue=4&rft.spage=100344&rft_id=info:doi/10.1016%2Fj.jorep.2024.100344&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_f87bdf53a1c44be092b8cfcd14ef6db8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2773-157X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2773-157X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2773-157X&client=summon