Assessment of mature serum brain-derived neurotrophic factor (BDNF) is not superior to total serum BDNF in prediction of antidepressant treatment outcome

• Published in: European psychiatry Vol. 33; no. S1; p. S410
• Main Authors: Eckert, A, Mikoteit, T, Beck, J, Hemmeter, U.M, Brand, S, Schmitt, K, Bischof, R, Delini-Stula, A, Holsboer-Trachsler, E
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.03.2016
• Subjects: Internal Medicine; Psychiatry

Background Serum BDNF levels are decreased in major depressive disorder (MDD) and tend to normalize under antidepressant treatment, serving as a treatment outcome predictor. BDNF is initially synthetized as precursor protein proBDNF and is cleaved to mature BDNF (mBDNF) while only the latter exerts...