An Occult Leydig Cell Tumour in a Postmenopausal Woman Presenting with Alopecia and Hirsutism: A Case Report
Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumour, especially in the presence of significantly elevated androgen levels. We present the case of a 68-year-old woman who was referred to an endocrinology clinic with insidious o...
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Published in | TouchREVIEWS in endocrinology Vol. 17; no. 1; pp. 75 - 78 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Touch Medical Media
01.04.2021
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Abstract | Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumour, especially in the presence of significantly elevated androgen levels. We present the case of a 68-year-old woman who was referred to an endocrinology clinic with insidious onset excessive facial hair growth and loss of scalp hair. Her testosterone levels were significantly elevated at 13 nmol/L (normal range: 0.1-1.4 nmol/L), although dehydroepiandrosterone sulphate and 17-hydroxyprogesterone levels were normal, suggestive of an ovarian source of androgens. Repeated radiologic investigations, including pelvic ultrasound, and abdominal and pelvic computed tomography, could not identify the obvious source of androgens. Based on strong clinical suspicion of an ovarian tumour, she underwent an elective salpingo-oophorectomy, which detected an occult Leydig cell tumour on histopathological analysis. Post-operatively, her hyperandrogenic features significantly improved and testosterone levels normalized. |
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AbstractList | Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumour, especially in the presence of significantly elevated androgen levels. We present the case of a 68-year-old woman who was referred to an endocrinology clinic with insidious onset excessive facial hair growth and loss of scalp hair. Her testosterone levels were significantly elevated at 13 nmol/L (normal range: 0.1-1.4 nmol/L), although dehydroepiandrosterone sulphate and 17-hydroxyprogesterone levels were normal, suggestive of an ovarian source of androgens. Repeated radiologic investigations, including pelvic ultrasound, and abdominal and pelvic computed tomography, could not identify the obvious source of androgens. Based on strong clinical suspicion of an ovarian tumour, she underwent an elective salpingo-oophorectomy, which detected an occult Leydig cell tumour on histopathological analysis. Post-operatively, her hyperandrogenic features significantly improved and testosterone levels normalized. |
Author | Shrikrishnapalasuriyar, Natasha Yin, Win Shwana, Shuann Vij, Monica Kalhan, Atul |
AuthorAffiliation | 2. Singleton Hospital, Swansea, Wales, UK 1. Royal Glamorgan Hospital, Llantrisant, Wales, UK |
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Author_xml | – sequence: 1 givenname: Shuann surname: Shwana fullname: Shwana, Shuann organization: Royal Glamorgan Hospital, Llantrisant, Wales, UK – sequence: 2 givenname: Natasha surname: Shrikrishnapalasuriyar fullname: Shrikrishnapalasuriyar, Natasha organization: Royal Glamorgan Hospital, Llantrisant, Wales, UK – sequence: 3 givenname: Win surname: Yin fullname: Yin, Win organization: Royal Glamorgan Hospital, Llantrisant, Wales, UK – sequence: 4 givenname: Monica surname: Vij fullname: Vij, Monica organization: Singleton Hospital, Swansea, Wales, UK – sequence: 5 givenname: Atul surname: Kalhan fullname: Kalhan, Atul organization: Royal Glamorgan Hospital, Llantrisant, Wales, UK |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35118450$$D View this record in MEDLINE/PubMed |
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Keywords | testosterone hirsutism Leydig cell tumour |
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License | Touch Medical Media 2021. www.copyright.com ali:free_to_read Access: This article is freely accessible at touchENDOCRINOLOGY.com © Touch Medical Media 2021. Compliance with ethics: Informed consent was received from the patient involved in this case study. Review Process: Double-blind peer review. Authorship: The named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. |
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Notes | Disclosures: Shuann Shwana, Natasha Shrikrishnapalasuriyar, Win Yin, Monica Vij and Atul Kalhan have no financial or non-financial relationships or activities to declare in relation to this article. |
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Title | An Occult Leydig Cell Tumour in a Postmenopausal Woman Presenting with Alopecia and Hirsutism: A Case Report |
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