IN FOCUS: Activation of platelets by heparin‐induced thrombocytopenia antibodies in the serotonin release assay is not dependent on the presence of heparin

• Published in: Journal of thrombosis and haemostasis Vol. 3; no. 10; pp. 2168 - 2175
• Main Authors: PRECHEL, M. M., MCDONALD, M. K., JESKE, W. P., MESSMORE, H. L., WALENGA, J. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.10.2005
• Subjects: heparin – platelet factor 4 antibody; heparin‐induced thrombocytopenia; platelets; serotonin release assay

The serotonin release assay (SRA) tests for antibodies responsible for heparin‐induced thrombocytopenia (HIT). By definition, SRA‐positive antibodies cause platelet serotonin release in vitro, in the presence of low concentrations of heparin, but not with excess heparin. Many SRA‐positive sera activ...