A study of silver (I) perchlorate as an effective promoter for chemical glycosylation with thioimidates and thioglycosides

• Published in: Reports in organic chemistry Vol. 4; p. 1
• Main Authors: Hasty, Scott J, Ranade, Sneha C, Demchenko, Alexei V
• Format: Journal Article
• Language: English
• Published: Macclesfield Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd
• Subjects: Carbohydrates; Chemistry; Chromatography; Glycosylation; NMR; Nuclear magnetic resonance; Physiological aspects; Silver compounds; United States; United States > US; Missouri

It has been previously acknowledged that perchlorate salts may be beneficial for the formation of 1,2-cis glycosides. Here, we demonstrate the effectiveness of silver (I) perchlorate as a powerful promoter of glycosyl thioimidate activation. Improved 1,2-cis selectivity was obtained, compared agains...