TNF-α-308A allele Carrier Induced to Development of Chronic Lymphocytic Leukemia in Sudanese Population at Earlier Age
several studies have been performed to investigate the association of TNF-α-308G>ASNP and CLL susceptibility However, the results are inconsistent. This study aimed to investigate the association between TNF-α-308G>ASNP of the TNF-α gene and CLL risk in the Sudanese population and correlated g...
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Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 23; no. 10; pp. 3449 - 3455 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Thailand
West Asia Organization for Cancer Prevention
01.10.2022
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Abstract | several studies have been performed to investigate the association of TNF-α-308G>ASNP and CLL susceptibility However, the results are inconsistent. This study aimed to investigate the association between TNF-α-308G>ASNP of the TNF-α gene and CLL risk in the Sudanese population and correlated genotypes with clinicopathological features.
A case-control study was conducted in Khartoum state, during the period from April 2017 to April 2018, involved 110 CLL patients and 50 healthy volunteers. Physical examination, Complete Blood Count, and immunophenotype were performed in all patients to confirm the diagnosis. Clinical staging such as Rai and Binet were studied. CD38 and ZAP70 were performed by Flow Cytometry. Blood samples were collected from all participants; DNA was extracted by using ANALYTIKJENA Blood DNA Extraction Kit and analyzed TNF-α-308G>ASNP by using AS-PCR. The statistical analysis was performed using SPSS.
TNF-α-308G>A genotype frequencies were GG (10.0%), GA (87.3%), and AA (2.7%) among the CLL patients, and GG (14.0%), GA (80.0%), and AA (6.0%) in the control group. The comparison of CLL patients with the control group did not show any statistically significant relationship for the genotypic and allelic frequencies. Furthermore, no association was observed between the TNF-α-308G>ASNP and gender, hematological parameters, clinical stages systems, CD38 expression, and ZAP-70 expression. The presence of theTNF-α-308Aallele was associated with a lower mean age.
These results indicate that TNF-α-308G>A genotypes are not involved in the predisposition to the development of CLL. TNF-α-308A allele carrier induced to development of CLL at an earlier age. |
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AbstractList | several studies have been performed to investigate the association of TNF-α-308G>ASNP and CLL susceptibility However, the results are inconsistent. This study aimed to investigate the association between TNF-α-308G>ASNP of the TNF-α gene and CLL risk in the Sudanese population and correlated genotypes with clinicopathological features.
A case-control study was conducted in Khartoum state, during the period from April 2017 to April 2018, involved 110 CLL patients and 50 healthy volunteers. Physical examination, Complete Blood Count, and immunophenotype were performed in all patients to confirm the diagnosis. Clinical staging such as Rai and Binet were studied. CD38 and ZAP70 were performed by Flow Cytometry. Blood samples were collected from all participants; DNA was extracted by using ANALYTIKJENA Blood DNA Extraction Kit and analyzed TNF-α-308G>ASNP by using AS-PCR. The statistical analysis was performed using SPSS.
TNF-α-308G>A genotype frequencies were GG (10.0%), GA (87.3%), and AA (2.7%) among the CLL patients, and GG (14.0%), GA (80.0%), and AA (6.0%) in the control group. The comparison of CLL patients with the control group did not show any statistically significant relationship for the genotypic and allelic frequencies. Furthermore, no association was observed between the TNF-α-308G>ASNP and gender, hematological parameters, clinical stages systems, CD38 expression, and ZAP-70 expression. The presence of theTNF-α-308Aallele was associated with a lower mean age.
These results indicate that TNF-α-308G>A genotypes are not involved in the predisposition to the development of CLL. TNF-α-308A allele carrier induced to development of CLL at an earlier age. |
Author | Awadalkareem Omer, Awadalkareem Yasin Basabaeen, Ameen Abdulaziz Altayeb, Osama Ali Abdelgader, Enaam Abdelrhman Abdelateif, Nour Mahmoud Ahmed Babekir, Ebtihal Fadul, Eman Abbass Ibrahim, Ibrahim Khider Osman Abdelrahim, Sadia |
AuthorAffiliation | 3 Department of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan 1 Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan 2 Ministry of Health & Population, Hadhramout, Yemen 4 Department of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan 5 Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan |
AuthorAffiliation_xml | – name: 5 Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan – name: 1 Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – name: 4 Department of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – name: 3 Department of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan – name: 2 Ministry of Health & Population, Hadhramout, Yemen |
Author_xml | – sequence: 1 givenname: Ameen Abdulaziz orcidid: 0000-0003-0958-5212 surname: Basabaeen fullname: Basabaeen, Ameen Abdulaziz organization: Ministry of Health & Population, Hadhramout, Yemen – sequence: 2 givenname: Enaam Abdelrhman surname: Abdelgader fullname: Abdelgader, Enaam Abdelrhman organization: Department of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan – sequence: 3 givenname: Ebtihal surname: Ahmed Babekir fullname: Ahmed Babekir, Ebtihal organization: Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – sequence: 4 givenname: Nour Mahmoud surname: Abdelateif fullname: Abdelateif, Nour Mahmoud organization: Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – sequence: 5 givenname: Sadia surname: Osman Abdelrahim fullname: Osman Abdelrahim, Sadia organization: Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – sequence: 6 givenname: Awadalkareem Yasin surname: Awadalkareem Omer fullname: Awadalkareem Omer, Awadalkareem Yasin organization: Department of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan – sequence: 7 givenname: Osama Ali surname: Altayeb fullname: Altayeb, Osama Ali organization: Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan – sequence: 8 givenname: Eman Abbass surname: Fadul fullname: Fadul, Eman Abbass organization: Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan – sequence: 9 givenname: Ibrahim Khider orcidid: 0000-0002-8223-5369 surname: Ibrahim fullname: Ibrahim, Ibrahim Khider organization: Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan |
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Snippet | several studies have been performed to investigate the association of TNF-α-308G>ASNP and CLL susceptibility However, the results are inconsistent. This study... |
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SubjectTerms | Alleles Case-Control Studies Genetic Predisposition to Disease Genotype Humans Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Polymorphism, Single Nucleotide Tumor Necrosis Factor-alpha - genetics |
Title | TNF-α-308A allele Carrier Induced to Development of Chronic Lymphocytic Leukemia in Sudanese Population at Earlier Age |
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