Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses

• Published in: Research square
• Main Authors: Wang, Lin-Fa, Tan, Chee Wah, Chia, Wan Ni, Zhu, Feng, Young, Barnaby, Chantasrisawad, Napaporn, Hwa, Shi-Hsia, Yeoh, Aileen Ying-Yan, Lim, Beng Lee, Yap, Wee Chee, Pada, Surinder Kaur, Tan, Seow Yen, Jantarabenjakul, Watsamon, Chen, Shiwei, Zhang, Jinyan, Mah, Yun Yan, Chen, Vivian, Chen, Mark, Wacharapluesadee, Supaporn, Putcharoen, Opass, Lye, David
• Format: Journal Article
• Language: English
• Published: United States 23.02.2022

The SARS-CoV-2 B.1.1.529 lineage, Omicron variant, was first detected in November 2021 and carries 32 amino acid mutations in the spike protein (15 in RBD) and exhibits significant escape of neutralizing antibodies targeting the parental SARS-CoV-2 virus. Here, we performed a high-resolution multipl...