Pharmacokinetic Interaction between Zonisamide and Carbamazepine in Epileptic Patients

We examined the drug interaction between zonisamide (ZNS) and carbamazepine (CBZ), valproic acid (VPA) or phenobarbital (PB) in 27 epileptic patients by monitoring the ratio of serum concentration at the steady state to the ZNS dose administered (C/D ratio). The C/D ratio ZNS therapy combined with C...

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Bibliographic Details
Published inByōin yakugaku Vol. 24; no. 2; pp. 168 - 172
Main Authors OHTORI, TOHRU, HASHIMOTO, SHUJI, IKENISHI, MASAYUKI, NAKATSUKA, EITARO, YAMAMOTO, IKUYOSHI
Format Journal Article
LanguageJapanese
Published Japanese Society of Pharmaceutical Health Care and Sciences 1998
Subjects
C/D ratio
carbamazepine
drug interaction
epileptic patient
words zonisamide
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ISSN0389-9098
2185-9477
DOI10.5649/jjphcs1975.24.168

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Summary:We examined the drug interaction between zonisamide (ZNS) and carbamazepine (CBZ), valproic acid (VPA) or phenobarbital (PB) in 27 epileptic patients by monitoring the ratio of serum concentration at the steady state to the ZNS dose administered (C/D ratio). The C/D ratio ZNS therapy combined with CBZ was significantly decreased over that of ZNS monotherapy (p<0.01) whereas VPA or PB did not change the ZNS C/D ratio. Furthermore, the ZNS C/D ratio decreased with increasing the CBZ dose. Accordingly, careful therapeutic drug monitoring should be done when administering ZNS concomitantly with CBZ.
ISSN:0389-9098
2185-9477
DOI:10.5649/jjphcs1975.24.168