The Bioequivalence of Abexinostat (CRA‐024781) Tosylate Tablets (20 mg) in Chinese Healthy Subjects Under Fasting Conditions

• Published in: Clinical pharmacology in drug development Vol. 13; no. 9; pp. 1061 - 1070
• Main Authors: Li, Xiang, Guo, Wenqiang, Chen, Jian, Tan, Gewen
• Format: Journal Article
• Language: English
• Published: Oxford Wiley Subscription Services, Inc 01.09.2024
• Subjects: abexinostat (CRA‐024781); bioequivalence; healthy subjects; histone deacetylase inhibitor (HDACi); pharmacokinetics

This study aimed to investigate the pharmacokinetic parameters of single oral administration of postchange and prechange abexinostat (CRA‐024781) tosylate tablets in Chinese healthy subjects under fasting conditions, and assess the bioequivalence (BE) of the 2 formulations (Test [T1] and Reference [...