RETRACTED ARTICLE: A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy

• Published in: Cell death & disease Vol. 9; no. 11; p. 1098
• Main Authors: Zhang, Wenda, Yu, Wenying, Cai, Guiping, Zhu, Jiawen, Zhang, Chao, Li, Shanshan, Guo, Jianpeng, Yin, Guoping, Chen, Chen, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.10.2018; Springer Nature B.V
• Subjects: 13/1; 13/2; 13/31; 13/51; 14/1; 64/60; 82/1; 96/95; Antibodies; Biochemistry; Cell Biology; Cell Culture; Immunology; Life Sciences

Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. In this study, the natural product cryptotanshinone was firstly remodeled and modified as a more effective STAT3 inhibitor by structure-based...