Prevalence of molecular markers of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from West Africa during 2012–2022

• Published in: Scientific reports Vol. 14; no. 1; p. 26567
• Main Authors: Zhou, Ruimin, Li, Suhua, Ji, Penghui, Ruan, Shucheng, Liu, Ying, Yang, Chengyun, Qian, Dan, He, Zhiquan, Wang, Dan, Lu, Deling, Zhang, Hongwei, Deng, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.11.2024; Nature Publishing Group
• Subjects: 631/337; 692/308; 692/699; Antimalarial agents; Birth weight; Dihydrofolate reductase; Dihydropteroate synthase; Haplotypes; Humanities and Social Sciences; Malaria; multidisciplinary; Mutants; Parasite resistance; Plasmodium falciparum; Pyrimethamine; Science; Science (multidisciplinary); Sulfadoxine; Vector-borne diseases; Liberia

Sulfadoxine-pyrimethamine (SP) is a key drug recommended by the World Health Organization for the chemoprevention of malaria. However, the strategy is affected by the parasite resistance to SP. This study evaluated Plasmodium falciparum dihydrofolate reductase ( Pfdhfr ) and dihydropteroate synthase...