Design and identification of a novel, functionally subtype selective GABA A positive allosteric modulator (PF-06372865) - Owen, Robert M.; Blakemore, David C; Cao, Lishuang; Flanagan, Neil; Fish, Rebecca; Gibson, Karl R; Gurrell, Rachel; Huh, Chan Woo; Kammonen, Juha; Mortimer-Cassen, Elisabeth; Nickolls, Sarah; Omoto, Kiyoyuki; et al. (Journal of medicinal chemistry, 2019)
Keywords: Allosteric Regulation - drug effects; Chemistry, Medicinal; Drug Design; Humans; Imidazoles - chemistry; Imidazoles - pharmacology; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Pyridazines - chemistry; Pyridazines - pharmacology; Receptors, GABA-A - metabolism; Science & Technology; LORAZEPAM; EFFICACY; PHARMACOLOGY; CENTRAL-NERVOUS-SYSTEM; BENZODIAZEPINES; RECEPTORS; MULTIPARAMETER OPTIMIZATION; MK-0343; DISCOVERY; AGONIST