Breast cancer in adolescent and young adult Ivory coast women: epidemiological and clinical features and molecular subdivision

Background: To describe the anatomy and clinical features and then determine the histological and molecular profile of Ivorian women under 40 years. Methods: This is a retrospective multi-centre study descriptive and analytic performed over a period of 20 months. It involved 76 women on 355 selected...

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Published inInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology Vol. 10; no. 3; p. 848
Main Authors Aka, Edele Kacou, Horo, Apollinaire, Koffi, Abdoul, Fanny, Mohamed, Didi-Kouko, Coulibaly, Nda, Guy, Abouna, Alain, Kone, Mamourou
Format Journal Article
LanguageEnglish
Published International Journal of Reproduction, Contraception, Obstetrics and Gynecology 01.03.2021
Subjects
Breast cancer
Epidemiology
Teenagers
Women
Youth
Côte d'Ivoire
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Summary:Background: To describe the anatomy and clinical features and then determine the histological and molecular profile of Ivorian women under 40 years. Methods: This is a retrospective multi-centre study descriptive and analytic performed over a period of 20 months. It involved 76 women on 355 selected in the Ivoirian cancer registry. An additional immunohistochemical analysis to assess hormone receptors and HER overexpression in a single unit. Results: Adolescents and young adults represented 20.3% of women with breast cancer. The average age of women was 35 years. ([partial derivative]=3.4 years, 95% CI=[2.6415 to 4.1785]). 15.8% of patients had a good socioeconomic level with a stable job, well paid and 28.9% had a university degree. The discovery circumstances were a breast nodule (53%) followed by locoregional complications (21%) and breast self-examination (20%). The consultation delay was less than three months in 34.2% of cases. 78% of cancers were diagnosed in stage II and III. The most common histological subtypes were respectively RP (+) / Her (-) (41%) followed by triple negative (30%). Conclusions: This study showed that 20,3% of women under 40 years. The most tumors were classified as stage II and III of tumors at diagnosis. the most common histologic subtypes are the Luminal A (41%) and triple-negative (30%). This disease is more aggressive with a poor prognosis in this age group. Keywords: Breast cancer, Adolescents and young adults, Molecular profile, Cote d'Ivoire
ISSN:2320-1770
2320-1789
DOI:10.18203/2320-1770.ijrcog20210698