Soman-hydrolyzing and -detoxifying properties of an enzyme from a thermophilic bacterium

• Published in: Fundamental and applied toxicology Vol. 11; no. 3; pp. 373 - 380
• Main Authors: Chettur, Govindan, DeFrank, Joseph J., Gallo, Benedict J., Hoskin, Francis C.G., Mainer, Stephen, Robbins, Frederick M., Steinmann, Kathleen E., Walker, John E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Science (USA) 01.10.1988
• Subjects: Bacteria - enzymology; Cholinesterase Inhibitors; Electrodes; Hydrolysis; Inactivation, Metabolic; Isoflurophate - metabolism; Phosphoric Monoester Hydrolases - metabolism; Soman - metabolism; Soman - pharmacokinetics

An enzyme that hydrolyzes soman (1,2,2-trimethylpropyl methylphosphonofluoridate) and two other phosphonofluoridates, but does not hydrolyze DFP (diisopropylphosphorofluoridate), has been partially purified from a rod-shaped spore-forming gram-positive OT (obligate thermophilic) bacterium. The enzym...