Medulloblastoma and Drop Metastasis: MRI Evaluation and Optimized Protocol

Cerebrospinal fluid (CSF) seeding, with spinal intradural drop metastasis, is a form of spread encountered more frequently in pediatric patients than in adults, and it is frequently observed in medulloblastoma. Up to one-third of patients with medulloblastoma will eventually disperse through the CSF...

Full description

Saved in:
Bibliographic Details
Published inCurrent radiology reports (Philadelphia, PA ) Vol. 3; no. 7
Main Authors Silva, Frederico Adolfo Benevides, Senerchia, Andreza A., Cappellano, Andrea, Saba, Nasjla, Chinelati, Rogerio Marcio Kajimura, Lederman, Henrique
Format Journal Article
LanguageEnglish
Published New York Springer US 28.07.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Cerebrospinal fluid (CSF) seeding, with spinal intradural drop metastasis, is a form of spread encountered more frequently in pediatric patients than in adults, and it is frequently observed in medulloblastoma. Up to one-third of patients with medulloblastoma will eventually disperse through the CSF, in many instances in the spinal canal. Magnetic resonance imaging (MRI) is an accurate modality that can identify the localization and extent of lesions. The purpose of this paper is to review the evaluation of the spinal canal for drop metastasis related to disseminate medulloblastoma and details an optimized protocol for MRI of the spinal canal.
AbstractList Cerebrospinal fluid (CSF) seeding, with spinal intradural drop metastasis, is a form of spread encountered more frequently in pediatric patients than in adults, and it is frequently observed in medulloblastoma. Up to one-third of patients with medulloblastoma will eventually disperse through the CSF, in many instances in the spinal canal. Magnetic resonance imaging (MRI) is an accurate modality that can identify the localization and extent of lesions. The purpose of this paper is to review the evaluation of the spinal canal for drop metastasis related to disseminate medulloblastoma and details an optimized protocol for MRI of the spinal canal.
ArticleNumber 26
Author Silva, Frederico Adolfo Benevides
Lederman, Henrique
Chinelati, Rogerio Marcio Kajimura
Saba, Nasjla
Senerchia, Andreza A.
Cappellano, Andrea
Author_xml – sequence: 1
  givenname: Frederico Adolfo Benevides
  surname: Silva
  fullname: Silva, Frederico Adolfo Benevides
  email: fredericoadolfo@gmail.com
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
– sequence: 2
  givenname: Andreza A.
  surname: Senerchia
  fullname: Senerchia, Andreza A.
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
– sequence: 3
  givenname: Andrea
  surname: Cappellano
  fullname: Cappellano, Andrea
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
– sequence: 4
  givenname: Nasjla
  surname: Saba
  fullname: Saba, Nasjla
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
– sequence: 5
  givenname: Rogerio Marcio Kajimura
  surname: Chinelati
  fullname: Chinelati, Rogerio Marcio Kajimura
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
– sequence: 6
  givenname: Henrique
  surname: Lederman
  fullname: Lederman, Henrique
  organization: Institute of Pediatric Oncology-GRAACC/Federal University of São Paulo
BookMark eNp9kF9LwzAQwINMcM59AN_6BaqXNk1a32TOOVmZiD6HNH-ko21G0gr205tZH3zy4LjjuN9x_C7RrLOdRugaww0GYLeeAE5JDDgLCTQez9A8wZTFJE-y2Z_-Ai29P0CIPHAUz9FzqdXQNLZqhO9tKyLRqejB2WNU6j6MhK_9XVS-bqP1p2gG0de2-9nZH_u6rUetohdneyttc4XOjWi8Xv7WBXp_XL-tnuLdfrNd3e9imUA6xhVmhBY4kYlkwBTRioBUQHNjsMqznMlKpQUUEioTCChoarKKFLkWmVGMpguEp7vSWe-dNvzo6la4L46Bn3zwyQcPPvjJBx8Dk0yMD7vdh3b8YAfXhTf_gb4BWzRlKw
CitedBy_id crossref_primary_10_1097_RLU_0000000000001610
crossref_primary_10_1136_bcr_2022_253877
Cites_doi 10.1215/15228517-1-3-232
10.1200/JCO.2012.48.5052
10.1158/1078-0432.CCR-04-0499
10.1200/JCO.2010.28.5148
10.1200/JCO.2005.01.5479
10.1159/000064392
10.1016/j.hoc.2009.11.012
10.1227/01.NEU.0000339454.55968.F0
10.1002/path.2514
10.1097/00006123-200010000-00018
10.12703/P6-56
10.1093/neuonc/not151
10.1177/15910199000060S131
10.2214/AJR.05.0003
ContentType Journal Article
Copyright Springer Science+Business Media New York 2015
Copyright_xml – notice: Springer Science+Business Media New York 2015
DBID AAYXX
CITATION
DOI 10.1007/s40134-015-0106-z
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2167-4825
ExternalDocumentID 10_1007_s40134_015_0106_z
GroupedDBID -EM
0R~
203
30V
406
96X
AAAVM
AAFGU
AAHNG
AAIAL
AAJKR
AANXM
AANZL
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
AAZMS
ABBXA
ABDZT
ABECU
ABFGW
ABFTV
ABJOX
ABKAS
ABKCH
ABMQK
ABQBU
ABTEG
ABTKH
ABTMW
ABXPI
ACBMV
ACBRV
ACBYP
ACGFS
ACHSB
ACIGE
ACIPQ
ACKNC
ACMLO
ACOKC
ACTTH
ACVWB
ACWMK
ADHHG
ADINQ
ADKNI
ADKPE
ADMDM
ADOXG
ADURQ
ADYFF
ADZKW
AEBTG
AEFTE
AEGNC
AEJHL
AEJRE
AEOHA
AEPYU
AESKC
AESTI
AETCA
AEVLU
AEVTX
AEXYK
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGJBK
AGMZJ
AGQMX
AGWZB
AGYKE
AHAVH
AHBYD
AHYZX
AIAKS
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKLTO
AKQUC
ALFXC
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMXSW
AMYLF
AMYQR
ANMIH
ASPBG
AUKKA
AVXWI
AXYYD
BGNMA
CSCUP
DNIVK
DPUIP
EBLON
EBS
EIOEI
EJD
ESBYG
FERAY
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FYJPI
GGCAI
GGRSB
GJIRD
GQ6
HMJXF
HQYDN
HRMNR
HZ~
I0C
IKXTQ
IWAJR
IXD
J-C
JBSCW
JCJTX
JZLTJ
KOV
LLZTM
M4Y
NB0
NPVJJ
NQJWS
NU0
O9J
PT4
RLLFE
RSV
SHX
SISQX
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
STPWE
TSG
U9L
UG4
UOJIU
UTJUX
UZXMN
VFIZW
W48
ZMTXR
ZOVNA
AACDK
AAJBT
AASML
AAYXX
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AGQEE
AGRTI
AHSBF
AIGIU
CITATION
FEDTE
HVGLF
O9-
ROL
SJYHP
ID FETCH-LOGICAL-c203z-b1746912c2c707d4ed40cd068ff1d8587cbd3909c0bfc200963f5b498ea5fd763
IEDL.DBID AGYKE
ISSN 2167-4825
IngestDate Thu Sep 12 16:28:48 EDT 2024
Sat Dec 16 12:05:12 EST 2023
IsPeerReviewed false
IsScholarly true
Issue 7
Keywords Leptomeningeal spread
Drop metastasis
MRI
Spine
Medulloblastoma
Dissemination
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c203z-b1746912c2c707d4ed40cd068ff1d8587cbd3909c0bfc200963f5b498ea5fd763
ParticipantIDs crossref_primary_10_1007_s40134_015_0106_z
springer_journals_10_1007_s40134_015_0106_z
PublicationCentury 2000
PublicationDate 2015-07-28
PublicationDateYYYYMMDD 2015-07-28
PublicationDate_xml – month: 07
  year: 2015
  text: 2015-07-28
  day: 28
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
PublicationTitle Current radiology reports (Philadelphia, PA )
PublicationTitleAbbrev Curr Radiol Rep
PublicationYear 2015
Publisher Springer US
Publisher_xml – name: Springer US
References AlbrightALSpostoRHolmesEZeltzerPMFinlayJLWisoffJHCorrelation of neurosurgical subspecialization with outcomes in children with malignant brain tumorsNeurosurgery.2000478791:STN:280:DC%2BD3cvmt1ektQ%3D%3D1101442810.1097/00006123-200010000-00018
ZhukovaNRamaswamyVRemkeMPfaffEShihDJHMartinDCSubgroup-specific prognostic implications of TP53 mutation in medulloblastomaJ Clin Oncol.201331292729352383570610.1200/JCO.2012.48.5052
AdamskiJRamaswamyVHuangABouffetEAdvances in managing medulloblastoma and intracranial primitive neuro-ectodermal tumorsF1000Prime Rep.2014656410895425184046
ShermanJLCitrinCMGangarosaREBowenBJThe MR appearance of CSF pulsations in the spinal canalAm J Neuroradiol.198678798841:STN:280:DyaL2s%2FksFOitg%3D%3D3096108
FattetSHaberlerCLegoixPVarletPLellouch-TubianaALairSBeta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristicsJ Pathol.200921886941:CAS:528:DC%2BD1MXls1Ort7g%3D1919795010.1002/path.2514
HeltonKJGajjarAHillDABoopFAKunLELangstonJWMedulloblastoma metastatic to the suprasellar region at diagnosis: a report of six cases with clinicopathologic correlationPediatr Neurosurg.2002371111171218705510.1159/000064392
LisantiCCarlinCBanksKPWangDNormal MRI appearance and motion-related phenomena of CSFAm J Roentgenol.2007188371672510.2214/AJR.05.0003
MeyersSPWildenhainSLChangJKBourekasECBeattiePFKoronesDNPostoperative evaluation for disseminated medulloblastoma involving the spine: contrast-enhanced MR findings, CSF cytologic analysis, timing of disease occurrence, and patient outcomesAm J Neuroradiol.200021175717651:STN:280:DC%2BD3cvovVCjsA%3D%3D11039362
Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro-Oncology. 2013;15(Suppl 2):ii1–56. This paper presents a comprehensive uptodate epidemiology of primary malignant and non-malignant brain and CNS tumors.
ChoY-JTsherniakATamayoPSantagataSLigonAGreulichHIntegrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeJ Clin Oncol.2011291424143030829832109832410.1200/JCO.2010.28.5148
MiyasakaKAsanoTUshikoshiSHidaKKoyanagiIVascular anatomy of the spinal cord and classification of spinal arteriovenous malformationsInterv Neuroradiol.20006Suppl 1195198368591820667247
RayAA clinicobiological model predicting survival in medulloblastomaClin Cancer Res.200410761376201:CAS:528:DC%2BD2cXhtVanurzP1556999310.1158/1078-0432.CCR-04-0499
SalunkePGuptaKKovaiPSuraSAggarwalAPreoperative diffuse leptomeningeal spread in a medulloblastoma: paraplegia following surgery for posterior fossa and call for newer management protocolsJ Pediatr Neurosci.201162152329641622408671
EllisonDWOniludeOELindseyJCLusherMEWestonCLTaylorREBeta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children’s Cancer Study Group Brain Tumour CommitteeJ Clin Oncol.200523795179571:CAS:528:DC%2BD2MXht1CqsL7P1625809510.1200/JCO.2005.01.5479
Packer RJ, Macdonald T, Vezina G. Central nervous system tumors. Hematol Oncol Clin North Am. 2010;24:87–108. This paper has a comprehensive review of the most common pediatric brain tumors with frequency distribution.
PackerRJCogenPVezinaGRorkeLBMedulloblastoma: clinical and biologic aspectsNeuro Oncology.199912322501:STN:280:DC%2BD3MrgtFCruw%3D%3D19207471155031610.1215/15228517-1-3-232
KomotarRJRansomERConnolly ESJrTreatment of early childhood medulloblastoma by postoperative chemotherapy aloneNeurosurgery.2005574N10
AL Albright (106_CR14) 2000; 47
106_CR2
A Ray (106_CR13) 2004; 10
106_CR1
RJ Komotar (106_CR5) 2005; 57
DW Ellison (106_CR3) 2005; 23
J Adamski (106_CR8) 2014; 6
K Miyasaka (106_CR10) 2000; 6
SP Meyers (106_CR11) 2000; 21
S Fattet (106_CR4) 2009; 218
JL Sherman (106_CR16) 1986; 7
Y-J Cho (106_CR7) 2011; 29
KJ Helton (106_CR9) 2002; 37
RJ Packer (106_CR12) 1999; 1
C Lisanti (106_CR17) 2007; 188
P Salunke (106_CR15) 2011; 6
N Zhukova (106_CR6) 2013; 31
References_xml – volume: 1
  start-page: 232
  year: 1999
  ident: 106_CR12
  publication-title: Neuro Oncology.
  doi: 10.1215/15228517-1-3-232
  contributor:
    fullname: RJ Packer
– volume: 31
  start-page: 2927
  year: 2013
  ident: 106_CR6
  publication-title: J Clin Oncol.
  doi: 10.1200/JCO.2012.48.5052
  contributor:
    fullname: N Zhukova
– volume: 10
  start-page: 7613
  year: 2004
  ident: 106_CR13
  publication-title: Clin Cancer Res.
  doi: 10.1158/1078-0432.CCR-04-0499
  contributor:
    fullname: A Ray
– volume: 29
  start-page: 1424
  year: 2011
  ident: 106_CR7
  publication-title: J Clin Oncol.
  doi: 10.1200/JCO.2010.28.5148
  contributor:
    fullname: Y-J Cho
– volume: 7
  start-page: 879
  year: 1986
  ident: 106_CR16
  publication-title: Am J Neuroradiol.
  contributor:
    fullname: JL Sherman
– volume: 23
  start-page: 7951
  year: 2005
  ident: 106_CR3
  publication-title: J Clin Oncol.
  doi: 10.1200/JCO.2005.01.5479
  contributor:
    fullname: DW Ellison
– volume: 6
  start-page: 152
  issue: 2
  year: 2011
  ident: 106_CR15
  publication-title: J Pediatr Neurosci.
  contributor:
    fullname: P Salunke
– volume: 21
  start-page: 1757
  year: 2000
  ident: 106_CR11
  publication-title: Am J Neuroradiol.
  contributor:
    fullname: SP Meyers
– volume: 37
  start-page: 111
  year: 2002
  ident: 106_CR9
  publication-title: Pediatr Neurosurg.
  doi: 10.1159/000064392
  contributor:
    fullname: KJ Helton
– ident: 106_CR2
  doi: 10.1016/j.hoc.2009.11.012
– volume: 57
  start-page: N10
  issue: 4
  year: 2005
  ident: 106_CR5
  publication-title: Neurosurgery.
  doi: 10.1227/01.NEU.0000339454.55968.F0
  contributor:
    fullname: RJ Komotar
– volume: 218
  start-page: 86
  year: 2009
  ident: 106_CR4
  publication-title: J Pathol.
  doi: 10.1002/path.2514
  contributor:
    fullname: S Fattet
– volume: 47
  start-page: 879
  year: 2000
  ident: 106_CR14
  publication-title: Neurosurgery.
  doi: 10.1097/00006123-200010000-00018
  contributor:
    fullname: AL Albright
– volume: 6
  start-page: 56
  year: 2014
  ident: 106_CR8
  publication-title: F1000Prime Rep.
  doi: 10.12703/P6-56
  contributor:
    fullname: J Adamski
– ident: 106_CR1
  doi: 10.1093/neuonc/not151
– volume: 6
  start-page: 195
  issue: Suppl 1
  year: 2000
  ident: 106_CR10
  publication-title: Interv Neuroradiol.
  doi: 10.1177/15910199000060S131
  contributor:
    fullname: K Miyasaka
– volume: 188
  start-page: 716
  issue: 3
  year: 2007
  ident: 106_CR17
  publication-title: Am J Roentgenol.
  doi: 10.2214/AJR.05.0003
  contributor:
    fullname: C Lisanti
SSID ssj0000800761
Score 1.97385
SecondaryResourceType review_article
Snippet Cerebrospinal fluid (CSF) seeding, with spinal intradural drop metastasis, is a form of spread encountered more frequently in pediatric patients than in...
SourceID crossref
springer
SourceType Aggregation Database
Publisher
SubjectTerms Imaging
Medicine
Medicine & Public Health
MRI for Pediatric Oncology
MRI for Pediatric Oncology (H. Lederman
Radiology
Section Editor
Title Medulloblastoma and Drop Metastasis: MRI Evaluation and Optimized Protocol
URI https://link.springer.com/article/10.1007/s40134-015-0106-z
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NS8MwFA9zA_Hitzi_yMGT0tG1SZt6Gzqdk6qIg3kq-YQx1o61u_SvN-naylAPu4XwCuXl5eX93u_lBYBrHviBxKhr-cLXAAUrZVEl9IK4nGLsMWJzk9APX73BCA3HeNwATp26iKedipEsHHV9180AAVMwYWrNNArOt0ALm1epm6DVe_p6-cmsmBhIg_OKwvzr2_VDaJ0BLQ6Wx73VZb-06Edo6kmmnWXGOjz_3a1xg3_eB7tlnAl7K8M4AA0ZH4LtsGTSj8BQDzX6TJiOnrNkRiGNBXxYJHMYykxP0XSS3sHw4xn2637ghcyb9jGzSS4FfF8kWaLt6BiMHvuf9wOrfFfB4o7t5hbTKMQLug53uG_7AkmBbC5sjyjVFQQTnzPhBnbAbaa4YU88V2GGAiIpVkI7pBPQjJNYngJIKXc5l4Qi5CDFWNDllAmiUZnncB1LtcFNpehovmqfEdWNkgvtRFo7kdFOlLfBbaXGqNxJ6f_SZxtJn4Mdp1gH33LIBWhmi6W81OFExq5K-_kGv-nDMA
link.rule.ids 315,786,790,27957,27958,41116,42185,52146
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEB60gnrxLb7NwZOSksduHt6KtlZtqkgL9RT2CSIm0qaX_HonaVKp6MHbEiawzM7OzLff7CzAhQj9UFFim770EaBQrU2mJS6IKxilHg8sURzoR32vOyQPIzqq7nFP6mr3mpIsPfX8sluBBIqKiaLYDGFwvgwrBAMUbcBK6-718ftopUiCEJ3XHOZv_y5GoUUKtIwsnU0Y1HOaFZS8N6cZb4r8R7vGf056CzaqTNNozUxjG5ZUsgOrUcWl78IDDhF_phzz5yz9YAZLpHE7Tj-NSGX4iU3eJtdG9HJvtOcdwUuZJ_QyH2-5ksbzOM1StKQ9GHbag5uuWb2sYArHcnOTIw7xQtsRjvAtXxIliSWk5QVa2zKggS-4dEMrFBbXouBPPFdTTsJAMaoluqR9aCRpog7AYEy4QqiAEeIQzXloC8ZlgLjMcwRmU4dwWWs6_pw10IjnrZJL7cSonbjQTpwfwlWtxrjaS5O_pY_-JX0Oa91B1It79_3HY1h3yjXxTSc4gUY2nqpTTC4yflYZ0xdS78cE
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JT8JAFJ4oJMSLuxHXHjxpCl2mmzciIIsgMZLgqc6aEENLaLn01_tKWwxGD8Zb07xJ2jdvZr5v3ptvELphnuMJC-uqwx0gKJaUKpEcOsRkxLJs6mos3dAfDO3OGPcm1iS_5zQqqt2LlGR2piFVaQri-pzL-vrgW8oK0uqJtPAMKHGyjcoYRi2EeLnx-Nb_2mZJAREw9SKf-VPbzRVpMx26WmXae-i9-L6suOSjtoxpjSXfpBv_8QP7aDdHoEojC5kDtCWCQ1QZ5Dn2I9SDR-ClIQVcHYczopCAK81FOFcGIoZXJJpG98rgpau01krhK5tnmH1m00RwZbQI4xAi7BiN263Xh46a37igMkMzE5UCP7E93WAGczSHY8Gxxrhmu1Lq3LVch1FueprHNCpZmlexTWlR7LmCWJLDVHWCSkEYiFOkEMJMxoRLMDawpNTTGaHcBb5mGwxQVhXdFl7355mwhr-WUF55xwfv-Kl3_KSK7gqX-vkYi363PvuT9TWqjJpt_6k77J-jHWPVJY5quBeoFC-W4hIwR0yv8rj6BK4Rz98
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Medulloblastoma+and+Drop+Metastasis%3A+MRI+Evaluation+and+Optimized+Protocol&rft.jtitle=Current+radiology+reports+%28Philadelphia%2C+PA+%29&rft.au=Silva%2C+Frederico+Adolfo+Benevides&rft.au=Senerchia%2C+Andreza+A.&rft.au=Cappellano%2C+Andrea&rft.au=Saba%2C+Nasjla&rft.date=2015-07-28&rft.pub=Springer+US&rft.eissn=2167-4825&rft.volume=3&rft.issue=7&rft_id=info:doi/10.1007%2Fs40134-015-0106-z&rft.externalDocID=10_1007_s40134_015_0106_z
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2167-4825&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2167-4825&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2167-4825&client=summon