Possible interaction of herbal tea and carbamazepine

A study was conducted using Wistar rats to determine the effect of concurrent administration of a herbal tea prepared from dried flowers of Cassia auriculata and carbamazepine on (a) blood levels of the prescription drug and (b) changes in toxicity (as assessed by changes in hematological parameters...

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Bibliographic Details
Published inDrug metabolism and drug interactions Vol. 19; no. 3; p. 177
Main Authors Thabrew, M Ira, Munasinghe, T M Janake, Chackrewarthi, Surekha, Senarath, Susantha
Format Journal Article
LanguageEnglish
Published Germany 2003
Subjects
Animals
Anticonvulsants - blood
Anticonvulsants - toxicity
Beverages
Biological Availability
Carbamazepine - blood
Carbamazepine - toxicity
Cassia
Drug Interactions
Male
Plant Extracts - pharmacology
Rats
Rats, Wistar
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Summary:A study was conducted using Wistar rats to determine the effect of concurrent administration of a herbal tea prepared from dried flowers of Cassia auriculata and carbamazepine on (a) blood levels of the prescription drug and (b) changes in toxicity (as assessed by changes in hematological parameters, liver and kidney function, and histology of major body organs) that may occur due to drug interaction. Results demonstrate that in rats receiving the herbal tea and carbamazepine, the blood levels of the prescription drug were significantly enhanced by 47.1% (p <0.04) when compared with the levels in animals receiving only carbamazepine, with no apparent changes in toxicity. Concurrent ingestion of the herbal tea prepared from Cassia auriculata flowers with carbamazepine may therefore influence the bioavailability of the prescribed drug and hence its therapeutic potential.
ISSN:0792-5077
DOI:10.1515/DMDI.2003.19.3.177