Targeting of Murine Leukemia Virus Gag to the Plasma Membrane Is Mediated by PI(4,5)P 2 /PS and a Polybasic Region in the Matrix

• Published in: Journal of virology Vol. 84; no. 1; pp. 503 - 515
• Main Authors: Hamard-Peron, E., Juillard, F., Saad, J. S., Roy, C., Roingeard, P., Summers, M. F., Darlix, J.-L., Picart, C., Muriaux, D.
• Format: Journal Article
• Language: English
• Published: 01.01.2010

ABSTRACT Membrane targeting of the human immunodeficiency virus Gag proteins is dependent on phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P 2 ] located in the plasma membrane. In order to determine if evolutionarily distant retroviral Gag proteins are targeted by a similar mechanism, we generated...