Evaluation of the Effect of Kampo (herbal) Medicine to Diminish Climacteric Symptoms Induced by the GnRH Agonist
In the hormonal treatment of uterine myomas, which are estrogen dependent, GnRH agonist (GnRHa) therapy has become widespread. However, GnRHa therapy causes uncomfortable or harmful side effects such as climacteric symptoms. The aim of this study is to evaluate the effect of Kampo (herbal) medicine...
Saved in:
| Published in | Kampo Medicine Vol. 53; no. 5; pp. 537 - 543 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
The Japan Society for Oriental Medicine
2002
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0287-4857 1882-756X |
| DOI | 10.3937/kampomed.53.537 |
Cover
| Abstract | In the hormonal treatment of uterine myomas, which are estrogen dependent, GnRH agonist (GnRHa) therapy has become widespread. However, GnRHa therapy causes uncomfortable or harmful side effects such as climacteric symptoms. The aim of this study is to evaluate the effect of Kampo (herbal) medicine to diminish climacteric symptoms induced by the GnRHa. Twenty-six patients with symptomatic uterine myoma were recruited, and informed consent was obtained from all subjects. Leuprolide acetate depot 3.75mg (LA) as GnRHa was given with subcutaneous injection every four weeks for six months. After LA therapy was initiated, Toki-shakuyaku-san, Kami-shoyo-san, or Keishi-bukuryo-gan was given from the second month of treatment. Climacteric symptoms were evaluated with Simplified Menopausal Index, which was improved for Japanese women. In the present study, we found all three Kampo medicines were useful. In particular, Kami-shoyo-san was useful for climacteric symptoms induced by LA. Also, LA therapy combined with Keishi-bukuryo-gan had beneficial effects in uterine myomas. However, the precise mechanism by which results were achieved remains unclear. Therefore, further research may be necessary to evaluate the ability of Kampo medicines to diminish climacteric symptoms induced by GnRHa. |
|---|---|
| AbstractList | In the hormonal treatment of uterine myomas, which are estrogen dependent, GnRH agonist (GnRHa) therapy has become widespread. However, GnRHa therapy causes uncomfortable or harmful side effects such as climacteric symptoms. The aim of this study is to evaluate the effect of Kampo (herbal) medicine to diminish climacteric symptoms induced by the GnRHa. Twenty-six patients with symptomatic uterine myoma were recruited, and informed consent was obtained from all subjects. Leuprolide acetate depot 3.75mg (LA) as GnRHa was given with subcutaneous injection every four weeks for six months. After LA therapy was initiated, Toki-shakuyaku-san, Kami-shoyo-san, or Keishi-bukuryo-gan was given from the second month of treatment. Climacteric symptoms were evaluated with Simplified Menopausal Index, which was improved for Japanese women. In the present study, we found all three Kampo medicines were useful. In particular, Kami-shoyo-san was useful for climacteric symptoms induced by LA. Also, LA therapy combined with Keishi-bukuryo-gan had beneficial effects in uterine myomas. However, the precise mechanism by which results were achieved remains unclear. Therefore, further research may be necessary to evaluate the ability of Kampo medicines to diminish climacteric symptoms induced by GnRHa. |
| Author | HOSHIMOTO, Kazunori HOSHIMOTO, Kazufusa |
| Author_xml | – sequence: 1 fullname: HOSHIMOTO, Kazufusa organization: Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine – sequence: 1 fullname: HOSHIMOTO, Kazunori organization: Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine |
| BookMark | eNo9kN1rwjAUxcNwMHV73mset4dq2rRN8ijOqcwx2AfsraTJjY1rU2njwP9-VadwuJcL53e4nAHqudoBQvchGVFB2fhHVtu6Aj1KaCd2hfoh51HAkvS7h_ok4iyIecJu0KBtN4SksQhJH21nv7LcSW9rh2uDfQF4Zgwof7heDpH4oYAml-UjfgVtlXWAfY2fbGWdbQs8LW0llYfGKvyxr7a-rlq8dHqnQON8f0ycu_cFnqzrDvC36NrIsoW7_z1EX8-zz-kiWL3Nl9PJKlARoSzQJjVcC5LohMRc8JDw0FDDYxkpATmLKQgSSp3nPIJIKCajJM2NMppToSWnQzQ-5aqmbtsGTLZtuk-bfRaS7FBYdi4sS2gn1hGLE7FpvVzDxS8bb1UJF38oeHRkzoNdLKqQTQaO_gGBtH1K |
| ContentType | Journal Article |
| Copyright | The Japan Society for Oriental Medicine |
| Copyright_xml | – notice: The Japan Society for Oriental Medicine |
| DBID | AAYXX CITATION |
| DOI | 10.3937/kampomed.53.537 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1882-756X |
| EndPage | 543 |
| ExternalDocumentID | 10_3937_kampomed_53_537 article_kampomed1982_53_5_53_5_537_article_char_en |
| GroupedDBID | 2WC 5GY ABJNI ACGFS ALMA_UNASSIGNED_HOLDINGS CS3 JSF KQ8 RJT AAYXX CITATION |
| ID | FETCH-LOGICAL-c2037-df6f8d905d5048981081f3f84a2c9eb743e901adbb82e29c7a256bfcfd839da83 |
| ISSN | 0287-4857 |
| IngestDate | Tue Jul 01 04:39:18 EDT 2025 Wed Sep 03 06:30:43 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 5 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c2037-df6f8d905d5048981081f3f84a2c9eb743e901adbb82e29c7a256bfcfd839da83 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/kampomed1982/53/5/53_5_537/_article/-char/en |
| PageCount | 7 |
| ParticipantIDs | crossref_primary_10_3937_kampomed_53_537 jstage_primary_article_kampomed1982_53_5_53_5_537_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2002 |
| PublicationDateYYYYMMDD | 2002-01-01 |
| PublicationDate_xml | – year: 2002 text: 2002 |
| PublicationDecade | 2000 |
| PublicationTitle | Kampo Medicine |
| PublicationTitleAlternate | Kampo Med |
| PublicationYear | 2002 |
| Publisher | The Japan Society for Oriental Medicine |
| Publisher_xml | – name: The Japan Society for Oriental Medicine |
| References | 10) Koyama T: Role of Kampo (herbal) medicine japan, J. Jpn. Menopause. Soc, 1, 75-79 (1993 8) 武谷雄三, 他: 子宮筋腫に対する酢酸リュープロレリン除放性製剤 (TAP-144-SR) の臨床的有用性に関する検討, 産婦, 62, 741-769 (1995 4) Paoletti AM. et al.: Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analog treatment. Fertil. Steril, 65, 707-710 (1996 14) 槇本深, 他: 冷えなどを主訴とする症例に対するTJ23・TJ24の治療, 診療と新薬, 18, 473-481 (1982 15) 星本和倫, 他: ERT前後における血清中 Vascular endothelial growth factor, 血漿中ホモシステイン, 可溶性トロンボモジュリンについての検討, 日本更年期医学会雑誌, 8, 186-191 (2000 20) 坂本忍, 他: 桂枝茯苓丸による子宮筋腫, 子宮内膜症の治療, 38, 97-99 (1986 3) 中村元一, 他: 子宮筋腫患者に対する酢酸リュープロレリン除放性注射剤 (TAP-144-SR) の投与終了後の臨床経過骨塩量の回復を中心とした検討, 産婦人科の世界, 47, 729-742 (1995 13) 小山嵩夫, 他: 更年期婦人における漢方治療: 簡略化した更年期指数による評価, 産婦人科漢方研究のあゆみ, No 9, 診断と治療社, 東京, 30-34 (1992 12) 千村哲郎, 他: 子宮内膜症に対する酢酸ブセレリンと桂枝茯苓丸の併用療法, Prog. Med, 13, 1895 (1991 1) Mahenx R. et al.: Use of lutenizing hormone-releasing hormone agonist in uterine leiomyomas. Fertil. Steril, 47, 229-233 (1987 6) Friedman A. et al.: A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin “Add-back” regimens for women with leiomyomata uteri. J. Clin. Endocrino. Metab, 76, 1439-1445 (1993 7) 星本和倫, 他: Add-back 療法における結合型エストロゲン投与量調節の試み, 臨床婦人科産科, 54, 97-101 (2000 5) Barberi RL: Gonadotropin-releasing hormone agonists and estrogen-progestogen replacement therapy. Am. J. Obstet. Gynecol, 162, 593-595 (1990 9) 寺川直樹, 他: 酢酸リュープロレリン除放性製剤 (TAP-144-SR) の子宮筋腫に対する至適用量の検討, 産婦, 62, 569-592 (1995 18) 野口将道, 他: CGRP誘発 hot flush モデルを用いた産婦人科領域で用いられる漢方処方の比較, 産婦人科漢方研究のあゆみ No 17, 診断と治療社, 東京, 114-117 (2000 17) 飯塚進, 他: 卵巣摘出モデルにおけるストレス負荷の影響および加味逍遥散の作用, 産婦人科漢方研究のあゆみ No 16, 診断と治療社, 東京, 37-40 (1999 16) Kronenberg F. et al.: Menopausal hot flashes, thermoregulatory, cardiovascular, and circulating 32, 991 (1996 11) 矢内原巧, 他: 更年期の漢方療法, 産婦の世界, 39, 891-895 (1987 19) 桝沼悉: 桂枝茯苓丸は子宮内膜を改善させる, 産婦人科漢方研究のあゆみ No 7, 診断と治療社, 東京, 71-76 (1990 2) Andreyko JL. et al.: Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. Am. J. Obstet. Gynecol, 158, 903-910 (1998 |
| References_xml | – reference: 8) 武谷雄三, 他: 子宮筋腫に対する酢酸リュープロレリン除放性製剤 (TAP-144-SR) の臨床的有用性に関する検討, 産婦, 62, 741-769 (1995) – reference: 1) Mahenx R. et al.: Use of lutenizing hormone-releasing hormone agonist in uterine leiomyomas. Fertil. Steril, 47, 229-233 (1987) – reference: 7) 星本和倫, 他: Add-back 療法における結合型エストロゲン投与量調節の試み, 臨床婦人科産科, 54, 97-101 (2000) – reference: 12) 千村哲郎, 他: 子宮内膜症に対する酢酸ブセレリンと桂枝茯苓丸の併用療法, Prog. Med, 13, 1895 (1991) – reference: 20) 坂本忍, 他: 桂枝茯苓丸による子宮筋腫, 子宮内膜症の治療, 38, 97-99 (1986) – reference: 18) 野口将道, 他: CGRP誘発 hot flush モデルを用いた産婦人科領域で用いられる漢方処方の比較, 産婦人科漢方研究のあゆみ No 17, 診断と治療社, 東京, 114-117 (2000) – reference: 19) 桝沼悉: 桂枝茯苓丸は子宮内膜を改善させる, 産婦人科漢方研究のあゆみ No 7, 診断と治療社, 東京, 71-76 (1990) – reference: 17) 飯塚進, 他: 卵巣摘出モデルにおけるストレス負荷の影響および加味逍遥散の作用, 産婦人科漢方研究のあゆみ No 16, 診断と治療社, 東京, 37-40 (1999) – reference: 14) 槇本深, 他: 冷えなどを主訴とする症例に対するTJ23・TJ24の治療, 診療と新薬, 18, 473-481 (1982) – reference: 6) Friedman A. et al.: A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin “Add-back” regimens for women with leiomyomata uteri. J. Clin. Endocrino. Metab, 76, 1439-1445 (1993) – reference: 13) 小山嵩夫, 他: 更年期婦人における漢方治療: 簡略化した更年期指数による評価, 産婦人科漢方研究のあゆみ, No 9, 診断と治療社, 東京, 30-34 (1992) – reference: 10) Koyama T: Role of Kampo (herbal) medicine japan, J. Jpn. Menopause. Soc, 1, 75-79 (1993) – reference: 2) Andreyko JL. et al.: Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. Am. J. Obstet. Gynecol, 158, 903-910 (1998) – reference: 5) Barberi RL: Gonadotropin-releasing hormone agonists and estrogen-progestogen replacement therapy. Am. J. Obstet. Gynecol, 162, 593-595 (1990) – reference: 3) 中村元一, 他: 子宮筋腫患者に対する酢酸リュープロレリン除放性注射剤 (TAP-144-SR) の投与終了後の臨床経過骨塩量の回復を中心とした検討, 産婦人科の世界, 47, 729-742 (1995) – reference: 15) 星本和倫, 他: ERT前後における血清中 Vascular endothelial growth factor, 血漿中ホモシステイン, 可溶性トロンボモジュリンについての検討, 日本更年期医学会雑誌, 8, 186-191 (2000) – reference: 11) 矢内原巧, 他: 更年期の漢方療法, 産婦の世界, 39, 891-895 (1987) – reference: 16) Kronenberg F. et al.: Menopausal hot flashes, thermoregulatory, cardiovascular, and circulating 32, 991 (1996) – reference: 4) Paoletti AM. et al.: Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analog treatment. Fertil. Steril, 65, 707-710 (1996) – reference: 9) 寺川直樹, 他: 酢酸リュープロレリン除放性製剤 (TAP-144-SR) の子宮筋腫に対する至適用量の検討, 産婦, 62, 569-592 (1995) |
| SSID | ssj0064910 |
| Score | 1.2986623 |
| Snippet | In the hormonal treatment of uterine myomas, which are estrogen dependent, GnRH agonist (GnRHa) therapy has become widespread. However, GnRHa therapy causes... |
| SourceID | crossref jstage |
| SourceType | Index Database Publisher |
| StartPage | 537 |
| SubjectTerms | climacteric symptoms GnRH agonist Kami-shoyo-san Keishi-bukuryo-gan Toki-shakuyaku-san uterine myomas |
| Title | Evaluation of the Effect of Kampo (herbal) Medicine to Diminish Climacteric Symptoms Induced by the GnRH Agonist |
| URI | https://www.jstage.jst.go.jp/article/kampomed1982/53/5/53_5_537/_article/-char/en |
| Volume | 53 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Kampo Medicine, 2002/09/20, Vol.53(5), pp.537-543 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwFLbKQIgXxFWMm_zAw1CV0jhxHD9WYygwlQrWSXuLnMSGAk2qLn3Y_g3_lONb1lQgMcSL1aR2nPj7cvL5co4ReiXDknMZioCnsQhikSh452LoqijK-Dhi41TpAf3pxyQ7jT-c0bPB4OfWqqVNW4zKy9_6lfwLqnAOcNVestdAtrsonIDfgC-kgDCkf4XxUReq20_1u2DEcHQslqtG60cAxUT153ZSRqtK0JtvFyaoyNfh4Y_F0kZsLocnF8tV2yzPh3pDj9JpU82j-nM2nHxpaucs5NWsrWO6Mz2fzU6y99PZfGZXa1xu1OZc_PHPulkvekMPV11U47YGH_O6t7Z0tnYunL16rS2DjlkQpzYW9UhaW2vEPTUbGXbG2EYOdqSjW5aVRmzrI01tbKdd-6-j-wFo3_XTg5gY0WjUlesF1XaQ5T5nyFOS0yinPmG5z6K934BsN9BNwlioV40ef-omqpKYh3YYzz2fjR6l7-PNzl30hM-tb6D9_bpBI2Xm99Bd1wfBE1v1fTSQ9QN02zfnQ7S64hVuFAYGYMsrfWQwxweWVa-xL4XbBntO4S1OYc8p7DiFiwtzRc0p7Dj1CJ2-O5ofZoHbmSMoifYrrVSi0oqPaUXhC8DTEISlihS87qTksgBVKkFniqooUiIJL5kAZV2oUlWgxyuRRo_RXt3U8gnCBIzCWJG4CqE4rwiXlAjGi4THYFyiZB8d-GbLVzYASw4dV93CHXoGtIjto4lt1i7j9WF--h-u8QzdMXsGmYG652ivXW_kC5CubfHSkOcXCZmhvQ |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+the+Effect+of+Kampo+%28herbal%29+Medicine+to+Diminish+Climacteric+Symptoms+Induced+by+the+GnRH+Agonist&rft.jtitle=Kampo+Medicine&rft.au=HOSHIMOTO%2C+Kazufusa&rft.au=HOSHIMOTO%2C+Kazunori&rft.date=2002&rft.pub=The+Japan+Society+for+Oriental+Medicine&rft.issn=0287-4857&rft.eissn=1882-756X&rft.volume=53&rft.issue=5&rft.spage=537&rft.epage=543&rft_id=info:doi/10.3937%2Fkampomed.53.537&rft.externalDocID=article_kampomed1982_53_5_53_5_537_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0287-4857&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0287-4857&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0287-4857&client=summon |