The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response

• Published in: bioRxiv
• Main Authors: Woltz, Ryan, Schweibenz, Brandon, Tsutakawa, Susan E, Zhao, Chen, Ma, LiChung, Shurina, Ben, Hura, Gregory L, John, Rachael, Vorobiev, Sergey, Swapna, Gvt, Solotchi, Mihai, Tainer, John A, Krug, Robert M, Patel, Smita S, Montelione, Gaetano T
• Format: Journal Article
• Language: English
• Published: United States 24.01.2024

Influenza A and B viruses overcome the host antiviral response to cause a contagious and often severe human respiratory disease. Here, integrative structural biology and biochemistry studies on non-structural protein 1 of influenza B virus (NS1B) reveal a previously unrecognized viral mechanism for...