La inhibición de la angiogénesis deteriora la morfología testicular en modelo de rata con varicocele izquierdo experimental
Resumen Introducción Se ha señalado que el varicocele podría favorecer la angiogénesis. Sin embargo, no se ha identificado claramente cómo la angiogénesis afecta a la morfología testicular o a la actividad espermatogénica. El objetivo de este estudio es investigar los efectos de la espironolactona,...
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| Published in | Actas urologicas españolas Vol. 38; no. 7; pp. 459 - 464 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Spanish |
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Elsevier Espana
01.09.2014
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| Abstract | Resumen Introducción Se ha señalado que el varicocele podría favorecer la angiogénesis. Sin embargo, no se ha identificado claramente cómo la angiogénesis afecta a la morfología testicular o a la actividad espermatogénica. El objetivo de este estudio es investigar los efectos de la espironolactona, como inhibidor de la angiogénesis, en la morfología del testículo ipsilateral en ratas con varicocele inducido en el lado izquierdo. Materiales y métodos Veinticuatro ratas albinas Wistar, adultas (12-14 meses) y de sexo masculino, fueron asignadas aleatoriamente a 4 grupos (n = 6, para cada uno): 1) grupo de control; 2) grupo con operación simulada; 3) grupo experimental con varicocele izquierdo; y 4) grupo experimental con varicocele izquierdo tratado con espironolactona (20 mg/kg/día). Se investigaron los resultados histopatológicos en testículos de rata. Resultados La densidad microvascular aumentó en el grupo con varicocele y la espironolactona no inhibió la angiogénesis ni por efecto antimineralcorticoide ni por efecto antiandrogénico. No obstante, la espermatogénesis se vio afectada en el grupo con varicocele tratado con espironolactona. Conclusión La angiogénesis parece ser un proceso protector en el varicocele. El tratamiento con espironolactona, probablemente al inhibir la angiogénesis, afecta a la morfología testicular. |
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| AbstractList | Resumen Introducción Se ha señalado que el varicocele podría favorecer la angiogénesis. Sin embargo, no se ha identificado claramente cómo la angiogénesis afecta a la morfología testicular o a la actividad espermatogénica. El objetivo de este estudio es investigar los efectos de la espironolactona, como inhibidor de la angiogénesis, en la morfología del testículo ipsilateral en ratas con varicocele inducido en el lado izquierdo. Materiales y métodos Veinticuatro ratas albinas Wistar, adultas (12-14 meses) y de sexo masculino, fueron asignadas aleatoriamente a 4 grupos (n = 6, para cada uno): 1) grupo de control; 2) grupo con operación simulada; 3) grupo experimental con varicocele izquierdo; y 4) grupo experimental con varicocele izquierdo tratado con espironolactona (20 mg/kg/día). Se investigaron los resultados histopatológicos en testículos de rata. Resultados La densidad microvascular aumentó en el grupo con varicocele y la espironolactona no inhibió la angiogénesis ni por efecto antimineralcorticoide ni por efecto antiandrogénico. No obstante, la espermatogénesis se vio afectada en el grupo con varicocele tratado con espironolactona. Conclusión La angiogénesis parece ser un proceso protector en el varicocele. El tratamiento con espironolactona, probablemente al inhibir la angiogénesis, afecta a la morfología testicular. Se ha señalado que el varicocele podría favorecer la angiogénesis. Sin embargo, no se ha identificado claramente cómo la angiogénesis afecta a la morfología testicular o a la actividad espermatogénica. El objetivo de este estudio es investigar los efectos de la espironolactona, como inhibidor de la angiogénesis, en la morfología del testículo ipsilateral en ratas con varicocele inducido en el lado izquierdo. Veinticuatro ratas albinas Wistar, adultas (12-14 meses) y de sexo masculino, fueron asignadas aleatoriamente a 4 grupos (n=6, para cada uno): 1) grupo de control; 2) grupo con operación simulada; 3) grupo experimental con varicocele izquierdo; y 4) grupo experimental con varicocele izquierdo tratado con espironolactona (20mg/kg/día). Se investigaron los resultados histopatológicos en testículos de rata. La densidad microvascular aumentó en el grupo con varicocele y la espironolactona no inhibió la angiogénesis ni por efecto antimineralcorticoide ni por efecto antiandrogénico. No obstante, la espermatogénesis se vio afectada en el grupo con varicocele tratado con espironolactona. La angiogénesis parece ser un proceso protector en el varicocele. El tratamiento con espironolactona, probablemente al inhibir la angiogénesis, afecta a la morfología testicular. It has been reported that varicocele might promote angiogenesis. However, it is not clearly identified how angiogenesis affect testicular morphology or spermatogenic activity. The objective of the study is to investigate the effect of spironolactone, as an angiogenesis inhibitor, on the ipsilateral testis morphology in left varicocele-induced rats. Twenty four adult (12-14 mo), male Wistar albino rats were randomly assigned to four groups (n=6, for each): 1. Control group, 2. Sham-operated group, 3. Experimental left varicocele group and, 4. Spironolactone (20mg/kg/day)-treated experimental left varicocele group. Histopathological findings in rat testis were investigated. Microvessel density increased in varicocele group and spironolactone inhibited angiogenesis neither by antimineralocorticoid, nor by antiandrogenic effect. However, spermatogenesis impaired in spironolactone treated varicocele group. Angiogenesis seems to be a protective process in varicocele. Spironolactone treatment, probably by inhibiting angiogenesis, impairs testicular morphology. |
| Author | Erdem, Ş.R Peşkircioğlu, Ç.L Gökhan-Köse, M Çaylak, B |
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| Keywords | Varicocele Factor de crecimiento endotelial vascular Angiogenesis Experimental left varicocele Rat Spironolactone Espironolactona Rata Angiogénesis Vascular endothelial growth factor Varicocele izquierdo experimental |
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| SubjectTerms | Angiogenesis Angiogénesis Espironolactona Experimental left varicocele Factor de crecimiento endotelial vascular Rat Rata Spironolactone Urology Varicocele Varicocele izquierdo experimental Vascular endothelial growth factor |
| Title | La inhibición de la angiogénesis deteriora la morfología testicular en modelo de rata con varicocele izquierdo experimental |
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