Approaches to synthesis of ([1,2,4]triazolo[1,5-c]quinazolin-2-yl)benzoic acids as potential anti-inflammators

• Published in: Farmacevtičnij žurnal Vol. 3; no. 3; pp. 44 - 54
• Main Author: Красовська, Н. І.
• Format: Journal Article
• Language: English; Ukrainian
• Published: The State Expert Center of the Ministry of Health of Ukraine 29.06.2022
• Subjects: 4]triazolo; 5-c]-quіnazolin-2-yl)benzoic acids; anti-inflammatory activity; dimroth rearrangement; heterocyclization; oxidative cyclization; spectral characteristics

Despite their high efficacy NSAIDs have significant side effects due to non-selective inhibition of COX-1 and COX-2. Due to this, medical chemists still pay considerable attention to their design and synthesis, in particular the creation of hybrid molecules that combine in their structure a fragment...