Risk Factors and Multiple Interaction Effects for Hyperammonemia in Patients Receiving Valproic Acid

• Published in: Fundamental & clinical pharmacology Vol. 39; no. 4; pp. e70030 - n/a
• Main Authors: Su, Chien‐Chou, Huang, Tsai‐Kuei, Shih, Ching‐Sen, Su, Yi‐Chia
• Format: Journal Article
• Language: English
• Published: England 01.08.2025
• Subjects: Adult; Age Factors; Aged; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy - drug therapy; Female; Humans; hyperammonemia; Hyperammonemia - chemically induced; Hyperammonemia - epidemiology; Male; Middle Aged; multiple interactions; Polypharmacy; Retrospective Studies; Risk Assessment; Risk Factors; valproic acid; Valproic Acid - administration & dosage; Valproic Acid - adverse effects; Young Adult; multiple interactions; hyperammonemia; valproic acid

ABSTRACT Background Valproic acid (VPA) use is associated with an increased risk of hyperammonemia (HA); however, the specific interactions between HA risk factors in VPA‐treated patients remain unclear. Objectives This study aimed to identify and assess the effects of multiple interactions between...