Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway

• Published in: Neuron (Cambridge, Mass.)
• Main Authors: Kim, Ji-il, Miura, Yuki, Li, Min-Yin, Revah, Omer, Selvaraj, Sridhar, Birey, Fikri, Meng, Xiangling, Thete, Mayuri Vijay, Pavlov, Sergey D., Andersen, Jimena, Pașca, Anca M., Porteus, Matthew H., Huguenard, John R., Pașca, Sergiu P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.10.2024
• Subjects: assembloids; disease; organoids; thalamocortical; thalamus; disease; thalamocortical; organoids; assembloids; thalamus

Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium channel, are associated with absence seizures, intellectual disability, and schizophrenia, but the cellular and circuit conseq...