Is the Loss of pRb Essential for the Mouse Skin

• Published in: Cell cycle (Georgetown, Tex.) Vol. 5; no. 6; pp. 625 - 630
• Main Authors: Ruiz, Sergio, Santos, Mirentxu, Paramio, Jesus M.
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 16.03.2006
• Subjects: Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cycle; Landes; Organogenesis; Proteins

The pRb pathway is inactivated in most, if not all, human and mouse tumors, including skin tumors.However, a relatively low frequency of Rb gene alterations is found. The embryonic lethality of pRbdeficientanimals restricts the analysis of these mice to midgestation and precludes the analysis of the...